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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2021 Volume 15 Issue 6

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Case Report

Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report

  • Authors:
    • Reo Inoue
    • Hiroaki Abe
    • Mitsuru Konishi
    • Rikuhei Tsuchida
    • Tatsuma Edamura
    • Masahiko Sumitani
  • View Affiliations / Copyright

    Affiliations: Anesthesiology and Pain Relief Centre, The University of Tokyo Hospital, Tokyo 113‑0033, Japan, Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113‑0033, Japan, Department of Pain and Palliative Medical Sciences, Faculty of Medicine, The University of Tokyo Hospital, Tokyo 113‑0033, Japan
  • Article Number: 254
    |
    Published online on: October 8, 2021
       https://doi.org/10.3892/mco.2021.2416
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Abstract

Hand‑foot syndrome (HFS) is a frequent adverse effect of various anti‑tumour drugs, such as capecitabine, that affects their dose‑limiting toxicity. The mechanism of HFS remains unknown and there are currently no effective strategies to treat HFS, except for cessation. The current study presented a female case where one hand, affected by brachial plexus infiltration due to the subclavian lymph node metastasis of breast cancer, exhibited not only pain and partial motor paralysis but also anhidrosis, oedema and skin colour changes. The patient met the diagnostic criteria for complex regional pain syndrome (CRPS). After treatment with capecitabine, their anhidrosis hand completely prevented HFS. The other hand and both feet demonstrated typical symptoms of HFS, which improved consequent to capecitabine cessation. The CRPS‑affected hand remained normal. Considering the limited presentation of HFS concomitant with anhidrosis, the exocrine release of condensed capecitabine through sweat glands might be a promising mechanism of HFS induction.
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Copy and paste a formatted citation
Spandidos Publications style
Inoue R, Abe H, Konishi M, Tsuchida R, Edamura T and Sumitani M: Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report. Mol Clin Oncol 15: 254, 2021.
APA
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., & Sumitani, M. (2021). Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report. Molecular and Clinical Oncology, 15, 254. https://doi.org/10.3892/mco.2021.2416
MLA
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., Sumitani, M."Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report". Molecular and Clinical Oncology 15.6 (2021): 254.
Chicago
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., Sumitani, M."Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report". Molecular and Clinical Oncology 15, no. 6 (2021): 254. https://doi.org/10.3892/mco.2021.2416
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue R, Abe H, Konishi M, Tsuchida R, Edamura T and Sumitani M: Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report. Mol Clin Oncol 15: 254, 2021.
APA
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., & Sumitani, M. (2021). Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report. Molecular and Clinical Oncology, 15, 254. https://doi.org/10.3892/mco.2021.2416
MLA
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., Sumitani, M."Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report". Molecular and Clinical Oncology 15.6 (2021): 254.
Chicago
Inoue, R., Abe, H., Konishi, M., Tsuchida, R., Edamura, T., Sumitani, M."Capecitabine‑induced hand‑foot syndrome does not emerge in the complex regional pain syndrome‑affected limb: A case report". Molecular and Clinical Oncology 15, no. 6 (2021): 254. https://doi.org/10.3892/mco.2021.2416
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