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January-2022 Volume 16 Issue 1

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma

  • Authors:
    • Takahiro Kimura
    • Takayuki Takahama
    • Tomoko Wakasa
    • Shiori Adachi
    • Yusaku Akashi
    • Takao Tamura
    • Katsunari Yane
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan, Department of Medical Oncology, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan, Department of Diagnostic Pathology, Kindai University Nara Hospital, Ikoma, Nara 630‑0293, Japan
  • Article Number: 2
    |
    Published online on: November 4, 2021
       https://doi.org/10.3892/mco.2021.2435
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Abstract

Immune checkpoint inhibitors (ICIs) have markedly changed the treatment landscape for melanoma; however, their efficacy and applications are currently limited and medical requirements remain unmet. The present case study reports on a 85‑year‑old female patient who visited our outpatient clinic with a 1‑month history of a buccal mucosa mass and was diagnosed with locally advanced mucosal melanoma of the head and neck. The patient's tumor progressed right after the administration of nivolumab, compromising oral intake. Palliative debulking surgery was performed. Subsequently, the other part of the melanoma on the hard palate slightly decreased in size without forming new lesions for more than one year after surgery. The present case exemplifies that tumor volume reduction surgery may increase the response to ICI and may prolong the duration of response. This combination therapy may be more effective in patients whose tumors increase in size after administration of ICIs or whose tumor is already large at the beginning of treatment. The combination of ICIs and debulking surgery may become an important treatment option in the future for locally advanced mucosal melanoma.
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1 

Gray-Schopfer V, Wellbrock C and Marais R: Melanoma biology and new targeted therapy. Nature. 445:851–857. 2007.PubMed/NCBI View Article : Google Scholar

2 

Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, Stroiakovski D, Lichinitser M, Dummer R, Grange F, Mortier L, et al: Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 372:30–39. 2015.PubMed/NCBI View Article : Google Scholar

3 

Tucker MA: Melanoma epidemiology. Hematol Oncol Clin North Am. 23:383–395. 2009.PubMed/NCBI View Article : Google Scholar

4 

Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, et al: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 364:2517–2526. 2011.PubMed/NCBI View Article : Google Scholar

5 

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, et al: Combined nivolumab and ipilimumab or monotherapy in untreated Melanoma. N Engl J Med. 373:23–34. 2015.PubMed/NCBI View Article : Google Scholar

6 

Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, et al: Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 372:320–330. 2015.PubMed/NCBI View Article : Google Scholar

7 

D'Angelo SP, Larkin J, Sosman JA, Lebbé C, Brady B, Neyns B, Schmidt H, Hassel JC, Hodi FS, Lorigan P, et al: Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: A pooled analysis. J Clin Oncol. 35:226–235. 2017.PubMed/NCBI View Article : Google Scholar

8 

Ozaki Y, Shindoh J, Miura Y, Nakajima H, Oki R, Uchiyama M, Masuda J, Kinowaki K, Kondoh C, Tanabe Y, et al: Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: A case report. BMC Cancer. 17(778)2017.PubMed/NCBI View Article : Google Scholar

9 

López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, et al: Update on primary head and neck mucosal melanoma. Head Neck. 38:147–155. 2016.PubMed/NCBI View Article : Google Scholar

10 

Wolchok JD, Chiarion-Sileni V, Gonzalez R, Rutkowski P, Grob JJ, Cowey CL, Lao CD, Wagstaff J, Schadendorf D, Ferrucci PF, et al: Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med. 377:1345–1356. 2017.PubMed/NCBI View Article : Google Scholar

11 

Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, et al: T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 545:60–65. 2017.PubMed/NCBI View Article : Google Scholar

12 

Guisier F, Cousse S, Jeanvoine M, Thiberville L and Salaun M: A rationale for surgical debulking to improve anti-PD1 therapy outcome in non small cell lung cancer. Sci Rep. 9(16902)2019.PubMed/NCBI View Article : Google Scholar

13 

Joseph RW, Elassaiss-Schaap J, Kefford R, Hwu WJ, Wolchok JD, Joshua AM, Ribas A, Hodi FS, Hamid O, Robert C, et al: Baseline tumor size is an independent prognostic factor for overall survival in patients with melanoma treated with pembrolizumab. Clin Cancer Res. 24:4960–4967. 2018.PubMed/NCBI View Article : Google Scholar

14 

Liu Y, Dong Y, Kong L, Shi F, Zhu H and Yu J: Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. J Hematol Oncol. 11(104)2018.PubMed/NCBI View Article : Google Scholar

15 

Oronsky B, Larson C, Reid TR and Carter CA: Case series: Abscopal benefit of surgery in 3 immunotherapy-treated patients with unresectable cancer. J Investig Med High Impact Case Rep: Jul 6, 2018 (Epub ahead of print). doi: 10.1177/2324709618786319.

16 

Eggermont AMM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, et al: Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med. 375:1845–1855. 2016.PubMed/NCBI View Article : Google Scholar

17 

Weber J, Mandala M, Del Vecchio M, Gogas HJ, Arance AM, Cowey CL, Dalle S, Schenker M, Chiarion-Sileni V, Marquez-Rodas I, et al: CheckMate 238 collaborators. Adjuvant nivolumab versus ipilimumab in resected stage III or IV melanoma. N Engl J Med. 377:1824–1835. 2017.PubMed/NCBI View Article : Google Scholar

18 

Eggermont AMM, Blank CU, Mandala M, Long GV, Atkinson V, Dalle S, Haydon A, Lichinitser M, Khattak A, Carlino MS, et al: adjuvant pembrolizumab versus placebo in resected stage III melanoma. N Engl J Med. 378:1789–1801. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kimura T, Takahama T, Wakasa T, Adachi S, Akashi Y, Tamura T and Yane K: Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma. Mol Clin Oncol 16: 2, 2022.
APA
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., & Yane, K. (2022). Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma. Molecular and Clinical Oncology, 16, 2. https://doi.org/10.3892/mco.2021.2435
MLA
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., Yane, K."Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma". Molecular and Clinical Oncology 16.1 (2022): 2.
Chicago
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., Yane, K."Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma". Molecular and Clinical Oncology 16, no. 1 (2022): 2. https://doi.org/10.3892/mco.2021.2435
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura T, Takahama T, Wakasa T, Adachi S, Akashi Y, Tamura T and Yane K: Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma. Mol Clin Oncol 16: 2, 2022.
APA
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., & Yane, K. (2022). Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma. Molecular and Clinical Oncology, 16, 2. https://doi.org/10.3892/mco.2021.2435
MLA
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., Yane, K."Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma". Molecular and Clinical Oncology 16.1 (2022): 2.
Chicago
Kimura, T., Takahama, T., Wakasa, T., Adachi, S., Akashi, Y., Tamura, T., Yane, K."Role of debulking surgery in combination with immune therapy: A successfully treated case of locally advanced mucosal melanoma". Molecular and Clinical Oncology 16, no. 1 (2022): 2. https://doi.org/10.3892/mco.2021.2435
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