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Article

Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma

  • Authors:
    • Hiroshi Nakamura
    • Takeshi Hara
    • Ryoko Mabuchi
    • Takuro Matsumoto
    • Nobuhiko Nakamura
    • Soranobu Ninomiya
    • Junichi Kitagawa
    • Nobuhiro Kanemura
    • Yusuke Kito
    • Tsuyoshi Takami
    • Tatsuhiko Miyazaki
    • Tamotsu Takeuchi
    • Masahito Shimizu
    • Hisashi Tsurumi
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu 501‑1194, Japan, Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Gifu 501‑1194, Japan, Department of Pathology, Gifu University Hospital, Gifu 501‑1194, Japan
  • Article Number: 4
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    Published online on: November 4, 2021
       https://doi.org/10.3892/mco.2021.2437
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Abstract

Oxidative stress serves an important role in carcinogenesis. The present study investigated the clinical significance of oxidative stress as a prognostic factor for diffuse large B‑cell lymphoma (DLBCL). The participants comprised 55 consecutive patients with DLBCL. A commercially available derivatives of reactive oxygen metabolites (d‑ROMs) test kit was used to assess oxidant levels. Similarly, a commercially available biological antioxidant potential (BAP) test was used to assess antioxidant levels. The antioxidative/oxidative stress ratio was calculated as d‑ROMs/BAP. The median serum concentration of d‑ROMs was 425 µM. The levels of d‑ROMs were significantly higher in patients with DLBCL than in healthy volunteers (P<0.01). The complete remission (CR) rates in patients with d‑ROMs <425 and ≥425 µM were 81.5 and 85.7%, respectively [not significant (NS)]. The 3‑year overall survival (OS) rates for patients with d‑ROMs <425 and ≥425 µM were 67.2 and 72.0%, respectively (NS). The median BAP was 2,002 µM. The CR rates of patients with BAP <2,002 and ≥2,002 µM were 77.8 and 88.9%, respectively (NS). The 3‑year OS rates of patients with BAP <2,002 and ≥2,002 µM were 60.9 and 75.9%, respectively (NS). No significant difference in the d‑ROMs/BAP ratio was observed between groups. Multivariate analysis revealed that d‑ROMs were an independent prognostic factor for progression-free survival.
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Copy and paste a formatted citation
Spandidos Publications style
Nakamura H, Hara T, Mabuchi R, Matsumoto T, Nakamura N, Ninomiya S, Kitagawa J, Kanemura N, Kito Y, Takami T, Takami T, et al: Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma. Mol Clin Oncol 16: 4, 2022.
APA
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S. ... Tsurumi, H. (2022). Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma. Molecular and Clinical Oncology, 16, 4. https://doi.org/10.3892/mco.2021.2437
MLA
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S., Kitagawa, J., Kanemura, N., Kito, Y., Takami, T., Miyazaki, T., Takeuchi, T., Shimizu, M., Tsurumi, H."Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma". Molecular and Clinical Oncology 16.1 (2022): 4.
Chicago
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S., Kitagawa, J., Kanemura, N., Kito, Y., Takami, T., Miyazaki, T., Takeuchi, T., Shimizu, M., Tsurumi, H."Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma". Molecular and Clinical Oncology 16, no. 1 (2022): 4. https://doi.org/10.3892/mco.2021.2437
Copy and paste a formatted citation
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Spandidos Publications style
Nakamura H, Hara T, Mabuchi R, Matsumoto T, Nakamura N, Ninomiya S, Kitagawa J, Kanemura N, Kito Y, Takami T, Takami T, et al: Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma. Mol Clin Oncol 16: 4, 2022.
APA
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S. ... Tsurumi, H. (2022). Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma. Molecular and Clinical Oncology, 16, 4. https://doi.org/10.3892/mco.2021.2437
MLA
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S., Kitagawa, J., Kanemura, N., Kito, Y., Takami, T., Miyazaki, T., Takeuchi, T., Shimizu, M., Tsurumi, H."Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma". Molecular and Clinical Oncology 16.1 (2022): 4.
Chicago
Nakamura, H., Hara, T., Mabuchi, R., Matsumoto, T., Nakamura, N., Ninomiya, S., Kitagawa, J., Kanemura, N., Kito, Y., Takami, T., Miyazaki, T., Takeuchi, T., Shimizu, M., Tsurumi, H."Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma". Molecular and Clinical Oncology 16, no. 1 (2022): 4. https://doi.org/10.3892/mco.2021.2437
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