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Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America

  • Authors:
    • Claudio Martin
    • Mauricio Cuello
    • Olga Barajas
    • Gonzalo Recondo
    • Sandra Aruachan
    • Herman Perroud
    • Susana Sena
    • Carlos Bonilla
    • Francisco Orlandi
    • Susana Berutti
    • Virginia Garcia Cocco
    • Alvaro Gomez
    • Ernesto Korbenfeld
    • Maycos Zapata
    • Juan Cundom
    • Eric Orellana
    • Susana Goncalves
    • Florencia Reinhold
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, Institute Alexander Fleming, Buenos Aires C1426ANZ, Argentina, Department of Oncology, Hospital of Clinics, Montevideo 11600, Uruguay, Department of Medical Oncology, Arturo Lopez Perez Foundation, Santiago 7500000, Chile, Department of Thoracic Oncology, Medical education and Clinical Research Centre, University Institute (CEMIC), Buenos Aires C1431FWO, Argentina, Department of Clinical Oncology, High Technology Medical Institute Oncomedica, Monteria 23001, Colombia, Department of Clinical Oncology, Women's Health Centre, Rosario 2000, Argentina, Department of Clinical Oncology; German Hospital, Buenos Aires PC C1118AAT, Argentina, Clinical Oncology Unit, National Cancer Institute of Colombia, Bogotá 110411, Colombia, Department of Clinical Oncology, Orlandi Oncology, Providencia 7500713, Chile, Department of Clinical Oncology, Italian Hospital of La Plata, La Plata B1900AXI, Argentina, Department of Clinical Oncology, Italian Hospital, Cordoba 5000, Argentina, Department of Medical Oncology, Hemato‑oncologos SA, Cali 760042, Colombia, Department of Medical Oncology, British Hospital of Buenos Aires, Buenos Aires C1280AEB, Argentina, Department of Medical Oncology, Cancer Institute Las Americas, Antioquia 050025, Colombia, Department of Medical Oncology, Lanari Institute, University of Buenos Aires, Buenos Aires C1427ARN, Argentina, Department of Clinical Oncology, Clinic Santa Maria, Santiago 7500000, Chile, AstraZeneca Medical Department, Buenos Aires CP1437, Argentina
    Copyright: © Martin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 6
    |
    Published online on: November 12, 2021
       https://doi.org/10.3892/mco.2021.2439
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Abstract

Lung cancer is a leading cause of cancer‑related deaths in Latin America, with non‑small cell lung cancer (NSCLC) being the most prevalent. The current study aimed to report real‑world data on epidermal growth factor receptor (EGFR) mutational testing and treatment regimens at diagnosis and progression in patients with metastatic NSCLC across four Latin American countries (Argentina, Chile, Colombia and Uruguay). A retrospective, multicenter, observational study was conducted in patients with NSCLC using medical records from participating countries. The study population was categorized into two cohorts: Cohort 1 comprised of newly diagnosed, treatment‑naïve patients with stage IV NSCLC; and cohort 2 comprised of stage IV NSCLC EGFR mutation (EGFRm)‑positive patients who had progressed after first‑ or second‑generation EGFR‑tyrosine kinase inhibitor (TKI) treatment. Measures included demographic variables, health characteristics, treatment regimen, molecular testing rate and turnaround time at diagnosis and at progression for cohorts 1 and 2, respectively. Descriptive statistics were used to summarize all study measures. Of the 462 patients enrolled, 431 were newly diagnosed or treatment naïve with metastatic NSCLC. In cohort 1, the majority of patients with private health insurance (57.31%) underwent molecular diagnosis while only 41.3% of patients within the public sector had access to testing. The average molecular testing rate in cohort 1 varied across countries, with Argentina having the highest testing rate (79%) and Uruguay the lowest (27.63%). EGFRm was observed in 22% of patients. Cohort 2 comprised 31 patients who had progressed after first‑ or second‑generation EGFR‑TKI treatment and of these, only 22 (70.97%) underwent testing after progression. Access to molecular testing is still a challenge impacting the choice of first‑line treatment in Latin American patients with NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Martin C, Cuello M, Barajas O, Recondo G, Aruachan S, Perroud H, Sena S, Bonilla C, Orlandi F, Berutti S, Berutti S, et al: Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America. Mol Clin Oncol 16: 6, 2022.
APA
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H. ... Reinhold, F. (2022). Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America. Molecular and Clinical Oncology, 16, 6. https://doi.org/10.3892/mco.2021.2439
MLA
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H., Sena, S., Bonilla, C., Orlandi, F., Berutti, S., Cocco, V. G., Gomez, A., Korbenfeld, E., Zapata, M., Cundom, J., Orellana, E., Goncalves, S., Reinhold, F."Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America". Molecular and Clinical Oncology 16.1 (2022): 6.
Chicago
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H., Sena, S., Bonilla, C., Orlandi, F., Berutti, S., Cocco, V. G., Gomez, A., Korbenfeld, E., Zapata, M., Cundom, J., Orellana, E., Goncalves, S., Reinhold, F."Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America". Molecular and Clinical Oncology 16, no. 1 (2022): 6. https://doi.org/10.3892/mco.2021.2439
Copy and paste a formatted citation
x
Spandidos Publications style
Martin C, Cuello M, Barajas O, Recondo G, Aruachan S, Perroud H, Sena S, Bonilla C, Orlandi F, Berutti S, Berutti S, et al: Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America. Mol Clin Oncol 16: 6, 2022.
APA
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H. ... Reinhold, F. (2022). Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America. Molecular and Clinical Oncology, 16, 6. https://doi.org/10.3892/mco.2021.2439
MLA
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H., Sena, S., Bonilla, C., Orlandi, F., Berutti, S., Cocco, V. G., Gomez, A., Korbenfeld, E., Zapata, M., Cundom, J., Orellana, E., Goncalves, S., Reinhold, F."Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America". Molecular and Clinical Oncology 16.1 (2022): 6.
Chicago
Martin, C., Cuello, M., Barajas, O., Recondo, G., Aruachan, S., Perroud, H., Sena, S., Bonilla, C., Orlandi, F., Berutti, S., Cocco, V. G., Gomez, A., Korbenfeld, E., Zapata, M., Cundom, J., Orellana, E., Goncalves, S., Reinhold, F."Real‑world evaluation of molecular testing and treatment patterns for EGFR mutations in non‑small cell lung cancer in Latin America". Molecular and Clinical Oncology 16, no. 1 (2022): 6. https://doi.org/10.3892/mco.2021.2439
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