Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
January-2022 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2022 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report

  • Authors:
    • Toshihiko Matsuo
    • Osamu Yamasaki
    • Takehiro Tanaka
    • Kuniaki Katsui
    • Takahiro Waki
  • View Affiliations / Copyright

    Affiliations: Regenerative and Reconstructive Medicine (Ophthalmology), Okayama University Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama 700‑8558, Japan, Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8558, Japan, Division of Radiation Oncology, Department of Radiology, Kawasaki Medical School, Kurashiki, Okayama 701‑0192, Japan, Department of Radiology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708‑0841, Japan
    Copyright: © Matsuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 12
    |
    Published online on: November 18, 2021
       https://doi.org/10.3892/mco.2021.2445
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study describes proton beam therapy as a clinical option to achieve local control of giant conjunctival melanoma in an aged person, instead of orbital exenteration. An 80‑year‑old woman with one‑year history of left‑eye injection and hemorrhage experienced rapid growth of the ocular surface black mass. At the initial visit, a black, elastic hard, hemorrhage‑prone, thickened mass in the size of 30x40 mm with a presumed wide stalk covered the total area of the lid fissure on the left side. Biopsy of the mass demonstrated anomalous melanin‑containing cells in fibrin and hemorrhage, which were positive for cocktail‑mix antibodies against tyrosinase, melanoma antigen recognized by T cells‑1 and human melanoma black‑45, indicative of malignant melanoma. One month after the initial visit, the patient underwent proton beam therapy at the total dose of 70.4 Gy (relative biological effectiveness) in 32 fractions (~10 min each) in one and a half months. One month after the end of proton beam therapy, 3.5 months from the initial visit, the patient was found by computed tomographic scan to have multiple metastatic lesions in bilateral lung fields. With the evidence of absent BRAF mutation, the patient underwent intravenous administration of pembrolizumab 77.2 mg every three weeks five times in total. Then, three months after proton beam therapy, ocular surface melanoma almost subsided and the clear cornea allowed visualization of the intraocular lens inside the eye. In three weeks, spontaneous corneal perforation was plugged with iris incarceration. The patient died suddenly of unknown cause 7.5 months from the initial visit. The local control of giant conjunctival melanoma was achieved by proton beam therapy, leading to patient's satisfaction and better quality of life. Proton beam therapy, followed by immune checkpoint inhibitors, would become the future standard of care for unresectable giant conjunctival melanoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Matsuo T, Ogino Y, Ichimura K, Tanaka T and Kaji M: Clinicopathological correlation for the role of fluorodeoxyglucose positron emission tomography computed tomography in detection of choroidal malignant melanoma. Int J Clin Oncol. 19:230–239. 2014.PubMed/NCBI View Article : Google Scholar

2 

Matsuo T, Tanaka T and Yamasaki O: Lacrimal sac malignant melanoma in 15 Japanese patients: Case report and literature review. J Investig Med High Impact Case Rep. 7(2324709619888052)2019.PubMed/NCBI View Article : Google Scholar

3 

Seregard S: Conjunctival melanoma. Surv Ophthalmol. 42:321–350. 1998.PubMed/NCBI View Article : Google Scholar

4 

Vora GK, Demirci H, Marr B and Mruthyunjaya P: Advances in the management of conjunctival melanoma. Surv Ophthalmol. 62:26–42. 2017.PubMed/NCBI View Article : Google Scholar

5 

Jain P, Finger PT, Fili M, Damato B, Coupland SE, Heimann H, Kenawy N, Brouwer NJ, Marinkovic M, Van Duinen SG, et al: Conjunctival melanoma treatment outcomes in 288 patients: A multicentre international data-sharing study. Br J Ophthalmol. 105:1358–1364. 2021.PubMed/NCBI View Article : Google Scholar

6 

Ballo MT and Ang KK: Radiotherapy for cutaneous malignant melanoma: Rationale and indications. Oncology (Williston Park). 18:99–110, 113-114. 2004.PubMed/NCBI

7 

Gorayski P, Burmeister B and Foote M: Radiotherapy for cutaneous melanoma: Current and future applications. Future Oncol. 11:525–534. 2015.PubMed/NCBI View Article : Google Scholar

8 

López F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, Haigentz M Jr, Strojan P, Pellitteri PK, Bradford CR, et al: Update on primary head and neck mucosal melanoma. Head Neck. 38:147–155. 2016.PubMed/NCBI View Article : Google Scholar

9 

Grant-Freemantle MC, O'Neill BL and Clover AJP: The effectiveness of radiotherapy in the treatment of head and neck mucosal melanoma: Systematic review and meta-analysis. Head Neck. 43:323–333. 2021.PubMed/NCBI View Article : Google Scholar

10 

Wuestemeyer H, Sauerwein W, Meller D, Chauvel P, Schueler A, Steuhl KP, Bornfeld N and Anastassiou G: Proton radiotherapy as an alternative to exenteration in the management of extended conjunctival melanoma. Graefes Arch Clin Exp Ophthalmol. 244:438–446. 2006.PubMed/NCBI View Article : Google Scholar

11 

Westekemper H, Anastassiou G, Sauerwein W, Chauvel P, Bornfeld N, Steuhl KP and Meller D: Analysis of ocular surface alterations following proton beam radiation in eyes with conjunctival malignant melanoma. Ophthalmologe. 103:588–595. 2006.PubMed/NCBI View Article : Google Scholar : (In German).

12 

Krause L, Mladenova A, Bechrakis NE, Kreusel KM, Plath T, Moser L and Foerster M: Treatment modalities for conjunctival melanoma. Klin Monbl Augenheilkd. 226:1012–1016. 2009.PubMed/NCBI View Article : Google Scholar : (In German).

13 

Maschi-Cayla C, Doyen J, Gastaud P and Caujolle JP: Conjunctival melanomas and proton beam therapy. Acta Ophthalmol. 91(e647)2013.PubMed/NCBI View Article : Google Scholar

14 

Scholz SL, Hérault J, Stang A, Griewank KG, Meller D, Thariat J, Steuhl KP, Westekemper H and Sauerwein W: Proton radiotherapy in advanced malignant melanoma of the conjunctiva. Graefes Arch Clin Exp Ophthalmol. 257:1309–1318. 2019.PubMed/NCBI View Article : Google Scholar

15 

Thariat J, Salleron J, Maschi C, Fevrier E, Lassalle S, Gastaud L, Baillif S, Claren A, Baumard J, Herault J and Caujolle JP: Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas. Radiation Oncol. 14(239)2019.PubMed/NCBI View Article : Google Scholar

16 

Zenda S, Kawashima M, Nishio T, Kohno R, Nihei K, Onozawa M, Arahira S and Ogino T: Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck: A pilot study. Int J Radiat Oncol Biol Phys. 81:135–139. 2011.PubMed/NCBI View Article : Google Scholar

17 

Fuji H, Yoshikawa S, Kasami M, Murayama S, Onitsuka T, Kashiwagi H and Kiyohara Y: High-dose proton beam therapy for sinonasal mucosal malignant melanoma. Radiat Oncol. 9(162)2014.PubMed/NCBI View Article : Google Scholar

18 

Sakurai H, Ishikawa H and Okumura T: Proton beam therapy in Japan: Current and future status. Jpn J Clin Oncol. 46:885–892. 2016.PubMed/NCBI View Article : Google Scholar

19 

Larsen AC, Dahmcke CM, Dahl C, Siersma VD, Toft PB, Coupland SE, Prause JU, Guldberg P and Heegaard S: A retrospective review of conjunctival melanoma: Presentation, treatment and outcome and an investigation of features associated with BRAF mutations. JAMA Ophthalmol. 133:1295–1303. 2015.PubMed/NCBI View Article : Google Scholar

20 

Kiyohara T, Tanimura H, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Makimura K and Iwai H: Two cases of BRAF-mutated, bulbar conjunctival melanoma, and review of the published literature. Clin Exp Dermatol. 45:207–211. 2020.PubMed/NCBI View Article : Google Scholar

21 

Matsuo T and Yamasaki O: Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. Clin Case Rep. 5:694–700. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Matsuo T, Yamasaki O, Tanaka T, Katsui K and Waki T: Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report. Mol Clin Oncol 16: 12, 2022.
APA
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., & Waki, T. (2022). Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report. Molecular and Clinical Oncology, 16, 12. https://doi.org/10.3892/mco.2021.2445
MLA
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., Waki, T."Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report". Molecular and Clinical Oncology 16.1 (2022): 12.
Chicago
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., Waki, T."Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report". Molecular and Clinical Oncology 16, no. 1 (2022): 12. https://doi.org/10.3892/mco.2021.2445
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuo T, Yamasaki O, Tanaka T, Katsui K and Waki T: Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report. Mol Clin Oncol 16: 12, 2022.
APA
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., & Waki, T. (2022). Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report. Molecular and Clinical Oncology, 16, 12. https://doi.org/10.3892/mco.2021.2445
MLA
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., Waki, T."Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report". Molecular and Clinical Oncology 16.1 (2022): 12.
Chicago
Matsuo, T., Yamasaki, O., Tanaka, T., Katsui, K., Waki, T."Proton beam therapy followed by pembrolizumab for giant ocular surface conjunctival malignant melanoma: A case report". Molecular and Clinical Oncology 16, no. 1 (2022): 12. https://doi.org/10.3892/mco.2021.2445
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team