Non‑small cell lung cancer with multiple brain metastases remains relapse‑free for more than 13 years: A case report

Matsuzaki,Tatsu; Ikemura,Shinnosuke; Shinozaki,Taro; Iwami,Eri; Nakajima,Takahiro; Katayama,Masateru; Shimamoto,Yoshinori; Sasaki,Aya; Serizawa,Toru; Terashima,Takeshi

doi:10.3892/mco.2021.2448

Non‑small cell lung cancer with multiple brain metastases remains relapse‑free for more than 13 years: A case report

Authors:
- Tatsu Matsuzaki
- Shinnosuke Ikemura
- Taro Shinozaki
- Eri Iwami
- Takahiro Nakajima
- Masateru Katayama
- Yoshinori Shimamoto
- Aya Sasaki
- Toru Serizawa
- Takeshi Terashima
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Affiliations: Department of Respiratory Medicine, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba 272‑8513, Japan, Department of Neurosurgery, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba 272‑8513, Japan, Department of Pathology and Laboratory Medicine, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba 272‑8513, Japan, Tokyo Gamma Unit Center, Tsukiji Neurological Clinic, Tokyo 104‑0045, Japan
Published online on: November 21, 2021 https://doi.org/10.3892/mco.2021.2448
Article Number: 18
Copyright: © Matsuzaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Brain metastasis (BM) in patients with non‑small cell lung cancer (NSCLC) is usually associated with a poor prognosis. A 55‑year‑old Japanese man visited Tokyo Dental College Ichikawa General Hospital with complaints of motor aphasia and fatigue. Enhanced magnetic resonance imaging of the brain revealed multiple tumors. The patient's medical history included lung cancer surgery performed at another hospital 3 months prior to his visit to our hospital. Total resection of the left frontal tumor revealed BM from lung adenocarcinoma. Stereotactic radiosurgery (SRS) was performed for the remaining three BMs. At 9 months after SRS, another new BM was discovered, and SRS was again performed. More than 13 years have elapsed since the last SRS was performed, and the patient has remained relapse‑free. To the best of our knowledge, this is the first case report describing a patient with NSCLC with multiple BMs who has remained relapse‑free for >13 years with no neurological dysfunction, including cognitive deficit.

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