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Article

Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma

  • Authors:
    • Hiroki Sakai
    • Hiroyuki Kimura
    • Kanji Otsubo
    • Tomoyuki Miyazawa
    • Hideki Marushima
    • Koji Kojima
    • Motohiro Chosokabe
    • Naoki Furuya
    • Junki Koike
    • Kiyonaga Fujii
    • Toshihide Nishimura
    • Haruhiko Nakamura
    • Hisashi Saji
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, St. Marianna Medical University Hospital, Kawasaki, Kanagawa 216‑8511, Japan, Department of Pathology, St. Marianna Medical University Hospital, Kawasaki, Kanagawa 216‑8511, Japan, Department of Division of Respiratory Medicine, Department of Internal Medicine, St. Marianna Medical University Hospital, Kawasaki, Kanagawa 216‑8511, Japan, Department of Translational Medicine Informatics, St. Marianna Medical University Hospital, Kawasaki, Kanagawa 216‑8511, Japan
  • Article Number: 22
    |
    Published online on: November 30, 2021
       https://doi.org/10.3892/mco.2021.2455
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Abstract

Minichromosome maintenance (MCM) protein deregulation is associated with tumor formation, progression and malignant transformation. MCM2 is frequently expressed during premalignant lung cell proliferation and is a sensitive marker for the early detection of pulmonary malignant lesions. The present study was undertaken to investigate whether MCM2 expression is of clinical and prognostic value in patients who have undergone lung adenocarcinoma resection. Between January 2009 and December 2010, 102 consecutive patients underwent complete pulmonary resection (involving lobectomy or more extensive resection) for lung adenocarcinoma at St. Marianna Medical University Hospital (Kanagawa, Japan). Among those, 73 patients, who had a final pathological diagnosis of lung adenocarcinoma measuring ≥10 mm, were enrolled in the present study. High MCM2 expression was found in 35 patients (48.0%). Univariate analysis of the overall survival (OS) revealed that pathological stage and MCM2 expression were significant prognostic factors in lung adenocarcinoma (P<0.001 and P<0.002, respectively). Univariate analysis of the recurrence‑free survival (RFS), the significant prognostic factors included pathological stage, EGFR mutation status and MCM2 expression (P<0.001, P<0.034 and P<0.003, respectively). On multivariate survival analysis, high MCM2 expression and pathological stage II‑III were identified as independent strong prognostic factors (OS: HR=5.084, 95% CI: 1.715‑15.080, P=0.003; RFS: HR=2.761, 95% CI: 1.090‑6.998, P=0.032). Therefore, the findings of the present study demonstrated that MCM2 may serve as a potential biomarker and therapeutic target for lung adenocarcinoma.
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1 

Fujii K, Miyata Y, Takahashi I, Koizumi H, Saji H, Hoshikawa M, Takagi M, Nishimura T and Nakamura H: Differential Proteomic Analysis between Small Cell Lung Carcinoma (SCLC) and Pulmonary Carcinoid Tumors Reveals Molecular Signatures for Malignancy in Lung Cancer. Proteomics Clin Appl. 12(e1800015)2018.PubMed/NCBI View Article : Google Scholar

2 

Bell SP and Dutta A: DNA replication in eukaryotic cells. Annu Rev Biochem. 71:333–374. 2002.PubMed/NCBI View Article : Google Scholar

3 

Neves H and Kwok HF: In sickness and in health: The many roles of the minichromosome maintenance proteins. Biochim Biophys Acta Rev Cancer. 1868:295–308. 2017.PubMed/NCBI View Article : Google Scholar

4 

Liu YZ, Jiang YY, Hao JJ, Lu SS, Zhang TT, Shang L, Cao J, Song X, Wang BS, Cai Y, et al: Prognostic significance of MCM7 expression in the bronchial brushings of patients with non-small cell lung cancer (NSCLC). Lung Cancer. 77:176–182. 2012.PubMed/NCBI View Article : Google Scholar

5 

Gonzalez MA, Pinder SE, Callagy G, Vowler SL, Morris LS, Bird K, Bell JA, Laskey RA and Coleman N: Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol. 21:4306–4313. 2003.PubMed/NCBI View Article : Google Scholar

6 

Kaur G, Balasubramaniam SD, Lee YJ, Balakrishnan V and Oon CE: Minichromosome Maintenance Complex (MCM) Genes Profiling and MCM2 Protein Expression in Cervical Cancer Development. Asian Pac J Cancer Prev. 20:3043–3049. 2019.PubMed/NCBI View Article : Google Scholar

7 

Nasri Nasrabadi P, Nayeri Z, Gharib E, Salmanipour R, Masoomi F, Mahjoubi F and Zomorodipour A: Establishment of a CALU, AURKA, and MCM2 gene panel for discrimination of metastasis from primary colon and lung cancers. PLoS One. 15(e0233717)2020.PubMed/NCBI View Article : Google Scholar

8 

Goldstraw P and Groome P: Lung and pleural tumours. In: TNM Classification of Malignant Tumours. 7th edition. Sobin, LH, Gospodarowicz MK and Wittekind C (eds). Wiley-Blackwell, Chichester, West Sussex, pp 136-150, 2009.

9 

Travis W, Brambilla E and Müller-Hermelink HK (eds): World Health Organization Classification of Tumours: Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon, 2004.

10 

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, et al: International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6:244–285. 2011.PubMed/NCBI View Article : Google Scholar

11 

Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH and Coleman N: Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res. 5:2121–2132. 1999.PubMed/NCBI

12 

Dudderidge TJ, Stoeber K, Loddo M, Atkinson G, Fanshawe T, Griffiths DF and Williams GH: Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. Clin Cancer Res. 11:2510–2517. 2005.PubMed/NCBI View Article : Google Scholar

13 

Dudderidge TJ, McCracken SR, Loddo M, Fanshawe TR, Kelly JD, Neal DE, Leung HY, Williams GH and Stoeber K: Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer. Br J Cancer. 96:1384–1393. 2007.PubMed/NCBI View Article : Google Scholar

14 

Nishihara K, Shomori K, Fujioka S, Tokuyasu N, Inaba A, Osaki M, Ogawa T and Ito H: Minichromosome maintenance protein 7 in colorectal cancer: Implication of prognostic significance. Int J Oncol. 33:245–251. 2008.PubMed/NCBI

15 

Hua C, Zhao G, Li Y and Bie L: Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas. BMC Cancer. 14(526)2014.PubMed/NCBI View Article : Google Scholar

16 

Veena VS, George PS, Rajan K, Chandramohan K, Jayasree K and Sujathan K: Immunocytochemistry on Sputum Samples Predicts Prognosis of Lung Cancer. J Cytol. 36:38–43. 2019.PubMed/NCBI View Article : Google Scholar

17 

Liu YZ, Wang BS, Jiang YY, Cao J, Hao JJ, Zhang Y, Xu X, Cai Y and Wang MR: MCMs expression in lung cancer: Implication of prognostic significance. J Cancer. 8:3641–3647. 2017.PubMed/NCBI View Article : Google Scholar

18 

Ramnath N, Hernandez FJ, Tan DF, Huberman JA, Natarajan N, Beck AF, Hyland A, Todorov IT, Brooks JS and Bepler G: MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer. J Clin Oncol. 19:4259–4266. 2001.PubMed/NCBI View Article : Google Scholar

19 

Bryant VL, Elias RM, McCarthy SM, Yeatman TJ and Alexandrow MG: Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil. Mol Cancer Res. 13:1296–1305. 2015.PubMed/NCBI View Article : Google Scholar

20 

Jia M, Zheng D, Wang X, Zhang Y, Chen S, Cai X, Mo L, Hu Z, Li H, Zhou Z, et al: Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity. Int J Med Sci. 17:1652–1664. 2020.PubMed/NCBI View Article : Google Scholar

21 

Jin Y, Xiong A, Zhang Z, Li S, Huang H, Yu TT, Cao X and Cheng SY: MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2. Oncotarget. 5:4821–4833. 2014.PubMed/NCBI View Article : Google Scholar

22 

Liu F, Yuan JH, Huang JF, Yang F, Wang TT, Ma JZ, Zhang L, Zhou CC, Wang F, Yu J, et al: Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. Oncogene. 35:5422–5434. 2016.PubMed/NCBI View Article : Google Scholar

23 

Zhang X, Teng Y, Yang F, Wang M, Hong X, Ye LG, Gao YN and Chen GY: MCM2 is a therapeutic target of lovastatin in human non-small cell lung carcinomas. Oncol Rep. 33:2599–2605. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sakai H, Kimura H, Otsubo K, Miyazawa T, Marushima H, Kojima K, Chosokabe M, Furuya N, Koike J, Fujii K, Fujii K, et al: Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Mol Clin Oncol 16: 22, 2022.
APA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K. ... Saji, H. (2022). Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Molecular and Clinical Oncology, 16, 22. https://doi.org/10.3892/mco.2021.2455
MLA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16.1 (2022): 22.
Chicago
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16, no. 1 (2022): 22. https://doi.org/10.3892/mco.2021.2455
Copy and paste a formatted citation
x
Spandidos Publications style
Sakai H, Kimura H, Otsubo K, Miyazawa T, Marushima H, Kojima K, Chosokabe M, Furuya N, Koike J, Fujii K, Fujii K, et al: Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Mol Clin Oncol 16: 22, 2022.
APA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K. ... Saji, H. (2022). Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma. Molecular and Clinical Oncology, 16, 22. https://doi.org/10.3892/mco.2021.2455
MLA
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16.1 (2022): 22.
Chicago
Sakai, H., Kimura, H., Otsubo, K., Miyazawa, T., Marushima, H., Kojima, K., Chosokabe, M., Furuya, N., Koike, J., Fujii, K., Nishimura, T., Nakamura, H., Saji, H."Minichromosome maintenance 2 is an independent predictor of survival in patients with lung adenocarcinoma". Molecular and Clinical Oncology 16, no. 1 (2022): 22. https://doi.org/10.3892/mco.2021.2455
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