Pancreatic cancer diagnosed by the detection of gross hematuria due to urinary bladder metastasis: A case report

Kubota,Risa; Tsushima,Tomoyasu; Doi,Keisuke; Inoue,Yousuke; Shinno,Yoko; Ichikawa,Takaharu

doi:10.3892/mco.2021.2456

Pancreatic cancer diagnosed by the detection of gross hematuria due to urinary bladder metastasis: A case report

Authors:
- Risa Kubota
- Tomoyasu Tsushima
- Keisuke Doi
- Yousuke Inoue
- Yoko Shinno
- Takaharu Ichikawa
View Affiliations

Affiliations: Department of Urology, National Hospital Organization Okayama Medical Center, Okayama 701‑1192, Japan, Department of Urology, Iwakuni Medical Center, Iwakuni, Yamaguchi 740‑8510, Japan, Department of Urology, Hiroshima City Hospital, Hiroshima 730‑8518, Japan, Department of Pathology, National Hospital Organization Okayama Medical Center, Okayama 701‑1192, Japan
Published online on: December 1, 2021 https://doi.org/10.3892/mco.2021.2456
Article Number: 23
Copyright: © Kubota et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Pancreatic cancer is not easy to detect at its early stages due to difficulties in identifying symptoms at these stages. As it progresses, abdominal pain, loss of appetite, abdominal distension, jaundice and pain in the back, especially the lower back, might develop. Moreover, sudden onset or worsening of diabetes mellitus may be seen, which often prompts screening for the detection of pancreatic cancer. Since it rapidly spreads to surrounding tissues and organs, pancreatic cancer has a poor prognosis. However, metastasis to the bladder is rare, with few cases diagnosed on the basis of detecting gross hematuria. The current study presents a case of gross hematuria and exacerbated diabetes in a 90‑year‑old woman. Cystoscopy revealed a non‑papillary tumor in the posterior bladder wall. Pathological examination of bladder tumor specimens obtained via transurethral resection revealed adenocarcinoma. Subsequent systemic examinations revealed primary pancreatic cancer that had metastasized to the bladder. To the best of our knowledge, this is the second reported case of pancreatic cancer diagnosed based on the detection of gross hematuria due to bladder metastasis, since 1992.

View Figures

View References

1	Cancer Information Service, National Cancer Center, Japan: National Cancer Registry (Ministry of Health, Labour and Welfare). https://ganjoho.jp/reg_stat/statistics/data/dl/en.html. Accessed September 29, 2021.
2	American Cancer Society: Cancer Facts and Figures 2021. American Cancer Society, Atlanta, GA, 2021.
3	Cancer statistics Cancer Information Service, National Cancer Center, Japan (Vital Statistics of Japan, Ministry of Health, Labour and Welfare). https://ganjoho.jp/reg_stat/statistics/data/dl/en.html. Accessed September 29, 2021.
4	Monitoring of Cancer Incidence in Japan - Survival 2009-2011 Report (Center for Cancer Control and Information Services, National Cancer Center, 2020). https://ganjoho.jp/reg_stat/statistics/data/dl/en.html. Accessed September 29, 2021.
5	Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017.PubMed/NCBI View Article : Google Scholar
6	Tempero MA, Malafa MP, Al-Hawary M, Asbun H, Bain A, Behrman SW, Benson AB III, Binder E, Cardin DB, Cha C, et al: Pancreatic adenocarcinoma, Version 2.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:1028–1061. 2017.PubMed/NCBI View Article : Google Scholar
7	Shah A, Korrapati P, Siegel J and Kasmin F: Rare metastasis of primary pancreatic adenocarcinoma to the bladder. ACG Case Rep J. 5(e27)2018.PubMed/NCBI View Article : Google Scholar
8	Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, Gershenwald JE, Compton CC, Hess KR, Sullivan DC, et al: American Joint Committee on Cancer: AJCC Cancer Staging Manual. 8th edition. Springer, New York, NY, 2017. https://doi.org/10.1007/978-3-319-40618-3.
9	Yamaguchi K, Okusaka T, Shimizu K, Furuse J, Ito Y, Hanada K, Shimosegawa T, Yamaguchi K, Okusaka T, Shimizu K, et al: Committee for revision of clinical guidelines for pancreatic cancer of Japan Pancreas Society: EBM-based Clinical Guidelines for Pancreatic Cancer (2013) issued by the Japan Pancreas Society: A synopsis. Jpn J Clin Oncol. 44:883–888. 2014.PubMed/NCBI View Article : Google Scholar
10	Warden SS, Fiveash JG Jr, Tynes WV II and Schellhammer PF II: Urologic aspects of pancreatic adenocarcinoma. J Urol. 125:265–267. 1981.PubMed/NCBI View Article : Google Scholar
11	Goldstein AG: Metastatic carcinoma to the bladder. J Urol. 98:209–215. 1967.PubMed/NCBI View Article : Google Scholar
12	Velcheti V and Govindan R: Metastatic cancer involving bladder: A review. Can J Urol. 14:3443–3448. 2007.PubMed/NCBI
13	Klinger ME: Secondary tumors of the genito-urinary tract. J Urol. 65:144–153. 1951.PubMed/NCBI View Article : Google Scholar
14	Kiefer ED: Carcinoma of the pancreas. Arch Intern Med. 40:1–29. 1927.
15	Sommers SC and Meissner WA: Unusual carcinomas of the pancreas. AMA Arch Pathol. 58:101–111. 1954.PubMed/NCBI
16	Bell ET: Carcinoma of the pancreas. I. A clinical and pathologic study of 609 necropsied cases. II. The relation of carcinoma of the pancreas to diabetes mellitus. Am J Pathol. 33:499–523. 1957.PubMed/NCBI
17	Sheehan EE, Greenberg SD and Scott R Jr: Metastatic neoplasms of the bladder. J Urol. 90:281–284. 1963.PubMed/NCBI View Article : Google Scholar
18	van Dyk D, Lang R, Jutrin Y, Shapira J and Ravid M: Bizarre urologic manifestations of pancreas carcinoma. Hepatogastroenterology. 27:62–63. 1980.PubMed/NCBI
19	Chiang KS, Lamki N and Athey PA: Metastasis to the bladder from pancreatic adenocarcinoma presenting with hematuria. Urol Radiol. 13:187–189. 1992.PubMed/NCBI View Article : Google Scholar
20	Lavelle RS, Williams SB and O'Leary MP: An 84-year-old female with gross hematuria. Urology. 77:533–534. 2011.PubMed/NCBI View Article : Google Scholar
21	Cellini M and Deighton DA: Radiological case: Non-papillary bladder metastasis from pancreatic adenocarcinoma. Appl Radiol. 43:74–76. 2014.