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Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers

  • Authors:
    • Gabriel Allo
    • Ahu Damla Can
    • Roger Wahba
    • Nils Vogel
    • Tobias Goeser
    • Fabian Kütting
    • Dirk Waldschmidt
  • View Affiliations / Copyright

    Affiliations: Department for Gastroenterology and Hepatology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, D-50937 Cologne, Germany, Department of General, Visceral and Cancer and Transplant Surgery, University Hospital of Cologne, University of Cologne, D-50937 Cologne, Germany
    Copyright: © Allo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: December 24, 2021
       https://doi.org/10.3892/mco.2021.2485
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Abstract

Biliary tract cancers (BTC) are rare but aggressive. Due to limited anti‑tumor effects of current second‑ and later‑line treatment regimens, novel treatment options are required. Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil (FOLFnal‑IRI) achieved promising results as a second‑line treatment in patients with pancreatic cancer, warranting further investigation in BTC. In the present study, a retrospective analysis of patients receiving FOLFnal‑IRI after initial platinum‑based chemotherapy for advanced BTC between January 2016 and August 2020 at the University Hospital Cologne (Cologne, Germany) was performed. A total of 11 patients were identified who met the inclusion criteria. A total of 4 patients (36.4%) were female and the median age was 54 years. The proportion of patients suffering from gallbladder carcinoma, intrahepatic and extrahepatic cholangiocarcinoma was 18.2, 63.6 and 9.1%, respectively. Furthermore, 7 patients (63.6%) received FOLFnal‑IRI as their second‑, 3 (27.3%) as third‑ and one (9.1%) as their fourth‑line therapy. The disease control rate was 54.5% and 3 grade III toxicities were recorded. Progression‑free survival and overall survival (OS) after initiation of FOLFnal‑IRI was 5.1 and 12.4 months, respectively. OS after initial diagnosis was 24.7 months. FOLFnal‑IRI demonstrated promising antitumor potential with an acceptable safety profile as a subsequent therapy regimen in advanced biliary tract malignancies. Further randomized controlled trials of its value as a treatment option for BTC appear justified.
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Copy and paste a formatted citation
Spandidos Publications style
Allo G, Can AD, Wahba R, Vogel N, Goeser T, Kütting F and Waldschmidt D: Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers. Mol Clin Oncol 16: 52, 2022.
APA
Allo, G., Can, A.D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., & Waldschmidt, D. (2022). Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers. Molecular and Clinical Oncology, 16, 52. https://doi.org/10.3892/mco.2021.2485
MLA
Allo, G., Can, A. D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., Waldschmidt, D."Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers". Molecular and Clinical Oncology 16.2 (2022): 52.
Chicago
Allo, G., Can, A. D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., Waldschmidt, D."Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers". Molecular and Clinical Oncology 16, no. 2 (2022): 52. https://doi.org/10.3892/mco.2021.2485
Copy and paste a formatted citation
x
Spandidos Publications style
Allo G, Can AD, Wahba R, Vogel N, Goeser T, Kütting F and Waldschmidt D: Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers. Mol Clin Oncol 16: 52, 2022.
APA
Allo, G., Can, A.D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., & Waldschmidt, D. (2022). Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers. Molecular and Clinical Oncology, 16, 52. https://doi.org/10.3892/mco.2021.2485
MLA
Allo, G., Can, A. D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., Waldschmidt, D."Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers". Molecular and Clinical Oncology 16.2 (2022): 52.
Chicago
Allo, G., Can, A. D., Wahba, R., Vogel, N., Goeser, T., Kütting, F., Waldschmidt, D."Nanoliposomal irinotecan in combination with leucovorin and 5‑fluorouracil in advanced biliary tract cancers". Molecular and Clinical Oncology 16, no. 2 (2022): 52. https://doi.org/10.3892/mco.2021.2485
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