Open Access

Recurrent malignant melanoma of the uterine cervix treated with anti‑PD‑1 antibodies and anti‑CTLA‑4 antibodies: A case report

  • Authors:
    • Kenbun Sone
    • Asako Kukita
    • Yuri Masui
    • Daisuke Yamada
    • Aya Shinozaki‑Ushiku
    • Akira Kawata
    • Ayumi Taguchi
    • Yuichiro Miyamoto
    • Michihiro Tanikawa
    • Takayuki Iriyama
    • Mayuyo Mori‑Uchino
    • Tetsushi Tsuruga
    • Yutaka Osuga
  • View Affiliations

  • Published online on: January 17, 2022     https://doi.org/10.3892/mco.2022.2496
  • Article Number: 63
  • Copyright: © Sone et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In 5% of female patients with malignant melanoma (MM), MM develops from the genital tract. MM of the cervix is particularly rare. In the present case report, a 73‑year‑old woman with stage ⅢC cervical MM underwent modified radical hysterectomy, bilateral salpingo‑oophorectomy and pelvic lymph node dissection. A total of 4 months after surgery, multiple metastases were found in the brain, lung, liver, lymph nodes and bone. The patient underwent γ‑knife surgery of the brain and received treatment with anti PD‑1 antibodies (nivolumab) and anti‑CTLA4 antibodies (ipilimumab); however, they were ineffective and the patient subsequently died. To the best of our knowledge, this is the first report of treatment using two types of immune checkpoint inhibitors administered to a patient with cervical MM. Taken together with previous reports, this case suggests that immune checkpoint inhibitors may be less effective in cervical MM than in cutaneous MM; however, the number of cases is small. Further development of biomarkers to stratify efficacy is required.
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March-2022
Volume 16 Issue 3

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Spandidos Publications style
Sone K, Kukita A, Masui Y, Yamada D, Shinozaki‑Ushiku A, Kawata A, Taguchi A, Miyamoto Y, Tanikawa M, Iriyama T, Iriyama T, et al: Recurrent malignant melanoma of the uterine cervix treated with anti‑PD‑1 antibodies and anti‑CTLA‑4 antibodies: A case report. Mol Clin Oncol 16: 63, 2022
APA
Sone, K., Kukita, A., Masui, Y., Yamada, D., Shinozaki‑Ushiku, A., Kawata, A. ... Osuga, Y. (2022). Recurrent malignant melanoma of the uterine cervix treated with anti‑PD‑1 antibodies and anti‑CTLA‑4 antibodies: A case report. Molecular and Clinical Oncology, 16, 63. https://doi.org/10.3892/mco.2022.2496
MLA
Sone, K., Kukita, A., Masui, Y., Yamada, D., Shinozaki‑Ushiku, A., Kawata, A., Taguchi, A., Miyamoto, Y., Tanikawa, M., Iriyama, T., Mori‑Uchino, M., Tsuruga, T., Osuga, Y."Recurrent malignant melanoma of the uterine cervix treated with anti‑PD‑1 antibodies and anti‑CTLA‑4 antibodies: A case report". Molecular and Clinical Oncology 16.3 (2022): 63.
Chicago
Sone, K., Kukita, A., Masui, Y., Yamada, D., Shinozaki‑Ushiku, A., Kawata, A., Taguchi, A., Miyamoto, Y., Tanikawa, M., Iriyama, T., Mori‑Uchino, M., Tsuruga, T., Osuga, Y."Recurrent malignant melanoma of the uterine cervix treated with anti‑PD‑1 antibodies and anti‑CTLA‑4 antibodies: A case report". Molecular and Clinical Oncology 16, no. 3 (2022): 63. https://doi.org/10.3892/mco.2022.2496