|
1
|
Khan SA, Tavolari S and Brandi G:
Cholangiocarcinoma: Epidemiology and risk factors. Liver Int. 39
(Suppl 1):S19–S31. 2019.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Mao Y, Huang X, Shuang Z, Lin G, Wang J,
Duan F, Chen J and Li S: PARP inhibitor olaparib sensitizes
cholangiocarcinoma cells to radiation. Cancer Med. 7:1285–1296.
2018.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Papoutsoglou P, Louis C and Coulouarn C:
Transforming growth factor-beta (TGFbeta) signaling pathway in
cholangiocarcinoma. Cells. 8(960)2019.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Pancewicz-Wojtkiewicz J: Epidermal growth
factor receptor and notch signaling in non-small-cell lung cancer.
Cancer Med. 5:3572–3578. 2016.PubMed/NCBI View
Article : Google Scholar
|
|
5
|
Kandasamy K, Mohan SS, Raju R,
Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD,
Mathivanan S, Pecquet C, et al: NetPath: A public resource of
curated signal transduction pathways. Genome Biol.
11(R3)2010.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Hopfer O, Zwahlen D, Fey MF and Aebi S:
The Notch pathway in ovarian carcinomas and adenomas. Br J Cancer.
93:709–718. 2005.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Stockhausen MT, Kristoffersen K and
Poulsen HS: The functional role of Notch signaling in human
gliomas. Neuro Oncol. 12:199–211. 2010.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Kontomanolis EN, Kalagasidou S, Pouliliou
S, Anthoulaki X, Georgiou N, Papamanolis V and Fasoulakis ZN: The
notch pathway in breast cancer progression. ScientificWorldJournal.
2018(2415489)2018.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Huang Q, Li J, Zheng J and Wei A: The
carcinogenic role of the notch signaling pathway in the development
of hepatocellular carcinoma. J Cancer. 10:1570–1579.
2019.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Sriuranpong V, Borges MW, Ravi RK, Arnold
DR, Nelkin BD, Baylin SB and Ball DW: Notch signaling induces cell
cycle arrest in small cell lung cancer cells. Cancer Res.
61:3200–3205. 2001.PubMed/NCBI
|
|
11
|
Shao H, Cai L, Grichnik JM, Livingstone
AS, Velazquez OC and Liu ZJ: Activation of Notch1 signaling in
stromal fibroblasts inhibits melanoma growth by upregulating
WISP-1. Oncogene. 30:4316–4326. 2011.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Yamamoto M, Xin B, Watanabe K, Ooshio T,
Fujii K, Chen X, Okada Y, Abe H, Taguchi Y, Miyokawa N, et al:
Oncogenic determination of a broad spectrum of phenotypes of
hepatocyte-derived mouse liver tumors. Am J Pathol. 187:2711–2725.
2017.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Wang J, Dong M, Xu Z, Song X, Zhang S,
Qiao Y, Che L, Gordan J, Hu K, Liu Y, et al: Notch2 controls
hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene.
37:3229–3242. 2018.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Li X, Tao J, Cigliano A, Sini M, Calderaro
J, Azoulay D, Wang C, Liu Y, Jiang L, Evert K, et al: Co-activation
of PIK3CA and Yap promotes development of hepatocellular and
cholangiocellular tumors in mouse and human liver. Oncotarget.
6:10102–10115. 2015.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Zender S, Nickeleit I, Wuestefeld T,
Sörensen I, Dauch D, Bozko P, El-Khatib M, Geffers R, Bektas H,
Manns MP, et al: A critical role for notch signaling in the
formation of cholangiocellular carcinomas. Cancer Cell. 23:784–795.
2013.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Ishii T, Yasuchika K, Suemori H, Nakatsuji
N, Ikai I and Uemoto S: Alpha-fetoprotein producing cells act as
cancer progenitor cells in human cholangiocarcinoma. Cancer Lett.
294:25–34. 2010.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Zhou Q, Wang Y, Peng B, Liang L and Li J:
The roles of Notch1 expression in the migration of intrahepatic
cholangiocarcinoma. BMC Cancer. 13(244)2013.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Wu WR, Zhang R, Shi XD, Zhu MS, Xu LB,
Zeng H and Liu C: Notch1 is overexpressed in human intrahepatic
cholangiocarcinoma and is associated with its proliferation,
invasiveness and sensitivity to 5-fluorouracil in vitro. Oncol Rep.
31:2515–2524. 2014.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Gu Y, Xiao L, Ming Y, Zheng Z and Li W:
Corilagin suppresses cholangiocarcinoma progression through Notch
signaling pathway in vitro and in vivo. Int J Oncol. 48:1868–1876.
2016.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Li JH, Zhu XX, Li FX, Huang CS, Huang XT,
Wang JQ, Gao ZX, Li SJ, Xu QC, Zhao W and Yin XY: MFAP5 facilitates
the aggressiveness of intrahepatic Cholangiocarcinoma by activating
the Notch1 signaling pathway. J Exp Clin Cancer Res.
38(476)2019.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Ren J, Wang S, Jin L, Ma F, Zhou D and Cai
Q: Cinobufagin inhibits tumor growth by inducing apoptosis through
Notch signaling pathways in human cholangiocarcinoma. Transl Cancer
Res. 8:2461–2469. 2019.
|
|
22
|
Sheng Y, Wei J, Zhang Y, Gao X, Wang Z,
Yang J, Yan S, Zhu Y, Zhang Z, Xu D, et al: Mutated EPHA2 is a
target for combating lymphatic metastasis in intrahepatic
cholangiocarcinoma. Int J Cancer. 144:2440–2452. 2019.PubMed/NCBI View Article : Google Scholar
|
|
23
|
O'Rourke CJ, Matter MS, Nepal C,
Caetano-Oliveira R, Ton PT, Factor VM and Andersen JB:
Identification of a pan-gamma-secretase inhibitor response
signature for notch-driven cholangiocarcinoma. Hepatology.
71:196–213. 2020.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Wu WR, Shi XD, Zhang R, Zhu MS, Xu LB, Yu
XH, Zeng H, Wang J and Liu C: Clinicopathological significance of
aberrant Notch receptors in intrahepatic cholangiocarcinoma. Int J
Clin Exp Pathol. 7:3272–3279. 2014.PubMed/NCBI
|
|
25
|
Ding N, Che L, Li XL, Liu Y, Jiang LJ, Fan
B, Tao JY, Chen X and Ji JF: Oncogenic potential of IDH1R132C
mutant in cholangiocarcinoma development in mice. World J
Gastroenterol. 22:2071–2080. 2016.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Huntzicker EG, Hötzel K, Choy L, Che L,
Ross J, Pau G, Pau G, Sharma N, Siebel CW, Chen X and French DM:
Differential effects of targeting Notch receptors in a mouse model
of liver cancer. Hepatology. 61:942–952. 2015.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Che L, Fan B, Pilo MG, Xu Z, Liu Y,
Cigliano A, Cossu A, Palmieri G, Pascale RM, Porcu A, et al: Jagged
1 is a major Notch ligand along cholangiocarcinoma development in
mice and humans. Oncogenesis. 5(e274)2016.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Zhang S, Wang J, Wang H, Fan L, Fan B,
Zeng B, Tao J, Li X, Che L, Cigliano A, et al: Hippo cascade
controls lineage commitment of liver tumors in mice and humans. Am
J Pathol. 188:995–1006. 2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Xu M, Wang J, Xu Z, Li R, Wang P, Shang R,
Cigliano A, Ribback S, Solinas A, Pes GM, et al: SNAIL promotes the
cholangiocellular phenotype, but not epithelial-mesenchymal
transition, in a murine hepatocellular carcinoma model. Cancer Res.
79:5563–5574. 2019.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Cerec V, Andreola F and Pereira S: Effect
of verteporfin-PDT on the Notch signaling pathway in
cholangiocarcinoma (CCA) cell lines: SPIE; 7380, Photodynamic
Therapy: Back to the Future, 73806J 2009.
|
|
31
|
Kwon H, Song K, Han C, Zhang J, Lu L, Chen
W and Wu T: Epigenetic Silencing of miRNA-34a in human
cholangiocarcinoma via EZH2 and DNA methylation: Impact on
regulation of notch pathway. Am J Pathol. 187:2288–2299.
2017.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Guest RV, Boulter L, Dwyer BJ, Kendall TJ,
Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, et
al: Notch3 drives development and progression of
cholangiocarcinoma. Proc Natl Acad Sci USA. 113:12250–12255.
2016.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Scarzello AJ, Jiang Q, Back T, Dang H,
Hodge D, Hanson C, Subleski J, Weiss JM, Stauffer JK,
Chaisaingmongkol J, et al: LTβR signalling preferentially
accelerates oncogenic AKT-initiated liver tumours. Gut.
65:1765–1775. 2016.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Tschaharganeh DF, Xue W, Calvisi DF, Evert
M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER,
Weissmueller S, et al: p53-dependent Nestin regulation links tumor
suppression to cellular plasticity in liver cancer. Cell.
158:579–592. 2014.PubMed/NCBI View Article : Google Scholar
|
|
35
|
El Khatib M, Bozko P, Palagani V, Malek
NP, Wilkens L and Plentz RR: Activation of Notch signaling is
required for cholangiocarcinoma progression and is enhanced by
inactivation of p53 in vivo. PLoS One. 8(e77433)2013.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Frampton G, Coufal M, Li H, Ramirez J and
DeMorrow S: Opposing actions of endocannabinoids on
cholangiocarcinoma growth is via the differential activation of
Notch signaling. Exp Cell Res. 316:1465–1478. 2010.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Fox V, Gokhale PJ, Walsh JR, Matin M,
Jones M and Andrews PW: Cell-cell signaling through NOTCH regulates
human embryonic stem cell proliferation. Stem Cells. 26:715–723.
2008.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Chen J, Kesari S, Rooney C, Strack PR,
Chen J, Shen H, Wu L and Griffin JD: Inhibition of notch signaling
blocks growth of glioblastoma cell lines and tumor neurospheres.
Genes Cancer. 1:822–835. 2010.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Balint K, Xiao M, Pinnix CC, Soma A, Veres
I, Juhasz I, Brown EJ, Capobianco AJ, Herlyn M and Liu ZJ:
Activation of Notch1 signaling is required for
beta-catenin-mediated human primary melanoma progression. J Clin
Invest. 115:3166–3176. 2005.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Puget S, Grill J, Valent A, Bieche I,
Dantas-Barbosa C, Kauffmann A, Dessen P, Lacroix L, Geoerger B, Job
B, et al: Candidate genes on chromosome 9q33-34 involved in the
progression of childhood ependymomas. J Clin Oncol. 27:1884–1892.
2009.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Chen J, Chang H, Peng X, Gu Y, Yi L, Zhang
Q, Zhu J and Mi M: 3,6-dihydroxyflavone suppresses the
epithelial-mesenchymal transition in breast cancer cells by
inhibiting the Notch signaling pathway. Sci Rep.
6(28858)2016.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Wang X, Wu B and Zhong Z: Downregulation
of YAP inhibits proliferation, invasion and increases cisplatin
sensitivity in human hepatocellular carcinoma cells. Oncol Lett.
16:585–593. 2018.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Wei X, Jia Y, Lou H, Ma J, Huang Q, Meng
Y, Sun C, Yang Z, Li X, Xu S, et al: Targeting YAP suppresses
ovarian cancer progression through regulation of the PI3K/Akt/mTOR
pathway. Oncol Rep. 42:2768–2776. 2019.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Götte M, Greve B, Kelsch R, Müller-Uthoff
H, Weiss K, Kharabi Masouleh B, Sibrowski W, Kiesel L and Buchweitz
O: The adult stem cell marker Musashi-1 modulates endometrial
carcinoma cell cycle progression and apoptosis via Notch-1 and
p21WAF1/CIP1. Int J Cancer. 129:2042–2049. 2011.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Cheng C, Cui H, Zhang L, Jia Z, Song B,
Wang F, Li Y, Liu J, Kong P, Shi R, et al: Genomic analyses reveal
FAM84B and the NOTCH pathway are associated with the progression of
esophageal squamous cell carcinoma. Gigascience.
5(1)2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
De Salvo M, Raimondi L, Vella S, Adesso L,
Ciarapica R, Verginelli F, Pannuti A, Citti A, Boldrini R, Milano
GM, et al: Hyper-activation of Notch3 amplifies the proliferative
potential of rhabdomyosarcoma cells. PLoS One.
9(e96238)2014.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Singh S, Arcaroli J, Chen Y, Thompson DC,
Messersmith W, Jimeno A and Vasiliou V: ALDH1B1 is crucial for
colon tumorigenesis by modulating Wnt/β-catenin, notch and PI3K/Akt
signaling pathways. PLoS One. 10(e0121648)2015.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Zhang XS, Hu YH, Gao HY, Lan XW and Xue
YW: Downregulation of Notch1 inhibits the invasion and metastasis
of human gastric cancer cells SGC7901 and MKN74 in vitro through
PTEN activation and dephosphorylation of Akt and FAK. Mol Med Rep.
16:2318–2324. 2017.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Dumont AG, Yang Y, Reynoso D, Katz D,
Trent JC and Hughes DP: Anti-tumor effects of the Notch pathway in
gastrointestinal stromal tumors. Carcinogenesis. 33:1674–1683.
2012.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Yu XM, Phan T, Patel PN, Jaskula-Sztul R
and Chen H: Chrysin activates Notch1 signaling and suppresses tumor
growth of anaplastic thyroid carcinoma in vitro and in vivo.
Cancer. 119:774–781. 2013.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Jaskula-Sztul R, Pisarnturakit P,
Landowski M, Chen H and Kunnimalaiyaan M: Expression of the active
Notch1 decreases MTC tumor growth in vivo. J Surg Res. 171:23–27.
2011.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Dong X, Lin Q, Aihara A, Li Y, Huang CK,
Chung W, Tang Q, Chen X, Carlson R, Nadolny C, et al: Aspartate
β-Hydroxylase expression promotes a malignant pancreatic cellular
phenotype. Oncotarget. 6:1231–1248. 2015.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Sturla LM, Tong M, Hebda N, Gao J, Thomas
JM, Olsen M and de la Monte SM: Aspartate-β-hydroxylase (ASPH): A
potential therapeutic target in human malignant gliomas. Heliyon.
2(e00203)2016.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Adler JT, Hottinger DG, Kunnimalaiyaan M
and Chen H: Histone deacetylase inhibitors upregulate Notch-1 and
inhibit growth in pheochromocytoma cells. Surgery. 144:956–961;
discussion 961-2. 2008.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Walden D, Kunnimalaiyaan S, Sokolowski K,
Clark TG and Kunnimalaiyaan M: Antiproliferative and apoptotic
effects of xanthohumol in cholangiocarcinoma. Oncotarget.
8:88069–88078. 2017.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Huang CK, Iwagami Y, Aihara A, Chung W, de
la Monte S, Thomas JM, Olsen M, Carlson R, Yu T, Dong X and Wands
J: Anti-Tumor effects of second generation β-Hydroxylase inhibitors
on cholangiocarcinoma development and progression. PLoS One.
11(e0150336)2016.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Cao Y, Yu L, Dai G, Zhang S, Zhang Z, Gao
T and Guo W: Cinobufagin induces apoptosis of osteosarcoma cells
through inactivation of Notch signaling. Eur J Pharmacol.
794:77–84. 2017.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Sun Z, Zhou C, Liu F, Zhang W, Chen J, Pan
Y, Ma L, Liu Q, Du Y, Yang J and Wang Q: Inhibition of breast
cancer cell survival by Xanthohumol via modulation of the Notch
signaling pathway in vivo and in vitro. Oncol Lett. 15:908–916.
2018.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Gan RH, Lin LS, Xie J, Huang L, Ding LC,
Su BH, Peng XE, Zheng DL and Lu YG: FLI-06 intercepts notch
signaling and suppresses the proliferation and self-renewal of
tongue cancer cells. Onco Targets Ther. 12:7663–7674.
2019.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Dai L, He J, Liu Y, Byun J, Vivekanandan
A, Pennathur S, Fan X and Lubman DM: Dose-dependent proteomic
analysis of glioblastoma cancer stem cells upon treatment with
γ-secretase inhibitor. Proteomics. 11:4529–4540. 2011.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Tammam J, Ware C, Efferson C, O'Neil J,
Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, et al:
Down-regulation of the Notch pathway mediated by a gamma-secretase
inhibitor induces anti-tumour effects in mouse models of T-cell
leukaemia. Br J Pharmacol. 158:1183–1195. 2009.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Tanaka M, Setoguchi T, Hirotsu M, Gao H,
Sasaki H, Matsunoshita Y and Komiya S: Inhibition of Notch pathway
prevents osteosarcoma growth by cell cycle regulation. Br J Cancer.
100:1957–1965. 2009.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Li ZL, Chen C, Yang Y, Wang C, Yang T,
Yang X and Liu SC: Gamma secretase inhibitor enhances sensitivity
to doxorubicin in MDA-MB-231 cells. Int J Clin Exp Pathol.
8:4378–4387. 2015.PubMed/NCBI
|
|
64
|
Liu X, Xu QR, Xie WF and Wang MD: DAPT
suppresses the proliferation of human glioma cell line SHG-44.
Asian Pac J Trop Med. 7:552–556. 2014.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Li H, Li D and Meng N: Effects of RUNX3
mediated Notch signaling pathway on biological characteristics of
colorectal cancer cells. Int J Oncol. 50:2059–2068. 2017.PubMed/NCBI View Article : Google Scholar
|
|
66
|
He G, Mu T, Yuan Y, Yang W, Zhang Y, Chen
Q, Bian M, Pan Y, Xiang Q, Chen Z and Sun A: Effects of notch
signaling pathway in cervical cancer by curcumin mediated
photodynamic therapy and its possible mechanisms in vitro and in
vivo. J Cancer. 10:4114–4122. 2019.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Peng X, Zhou J, Li B, Zhang T, Zuo Y and
Gu X: Notch1 and PI3K/Akt signaling blockers DAPT and LY294002
coordinately inhibit metastasis of gastric cancer through mutual
enhancement. Cancer Chemother Pharmacol. 85:309–320.
2020.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL,
Liu JF, Yu GT, Liu B, Gutkind JS, Kulkarni AB, et al: NOTCH1
inhibition enhances the efficacy of conventional chemotherapeutic
agents by targeting head neck cancer stem cell. Sci Rep.
6(24704)2016.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Qin J, Wang R, Zhao C, Wen J, Dong H, Wang
S, Li Y, Zhao Y, Li J, Yang Y, et al: Notch signaling regulates
osteosarcoma proliferation and migration through Erk
phosphorylation. Tissue Cell. 59:51–61. 2019.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Tian Q, Xue Y, Zheng W, Sun R, Ji W, Wang
X and An R: Overexpression of hypoxia-inducible factor 1α induces
migration and invasion through Notch signaling. Int J Oncol.
47:728–738. 2015.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Jiang LY, Zhang XL, Du P and Zheng JH:
γ-Secretase Inhibitor, DAPT inhibits self-renewal and stemness
maintenance of ovarian cancer stem-like cells in vitro. Chin J
Cancer Res. 23:140–146. 2011.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Ji Q, Hao X, Zhang M, Tang W, Yang M, Li
L, Xiang D, Desano JT, Bommer GT, Fan D, et al: MicroRNA miR-34
inhibits human pancreatic cancer tumor-initiating cells. PLoS One.
4(e6816)2009.PubMed/NCBI View Article : Google Scholar
|
|
73
|
de Antonellis P, Medaglia C, Cusanelli E,
Andolfo I, Liguori L, De Vita G, Carotenuto M, Bello A, Formiggini
F, Galeone A, et al: MiR-34a targeting of Notch ligand delta-like 1
impairs CD15+/CD133+ tumor-propagating cells and supports neural
differentiation in medulloblastoma. PLoS One.
6(e24584)2011.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Wang J, Wang C, Meng Q, Li S, Sun X, Bo Y
and Yao W: siRNA targeting Notch-1 decreases glioma stem cell
proliferation and tumor growth. Mol Biol Rep. 39:2497–2503.
2012.PubMed/NCBI View Article : Google Scholar
|
