Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report

Rodrigues Vieira,Ana Cláudia; Monteiro Ferra,Joana Raquel; Vicente De Carvalho,Joana Sofia; Melo,Natália; Mota,Patrícia Caetano; E Bastos,Hélder Novais; Pereira,José Miguel; Moura,Conceição Souto; Morais,António

doi:10.3892/mco.2022.2504

March-2022 Volume 16 Issue 3

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March-2022 Volume 16 Issue 3

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Case Report

Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report

Authors:
- Ana Cláudia Rodrigues Vieira
- Joana Raquel Monteiro Ferra
- Joana Sofia Vicente De Carvalho
- Natália Melo
- Patrícia Caetano Mota
- Hélder Novais E Bastos
- José Miguel Pereira
- Conceição Souto Moura
- António Morais
View Affiliations / Copyright

Affiliations: Pulmonology Department, Egas Moniz Hospital, 1349‑019 Lisbon, Portugal, Pulmonology Department, Hospital Center of São João, 4200‑319 Porto, Portugal, Imaging Department, Hospital Center of São João, 4200‑319 Porto, Portugal, Pathology Department, Hospital Center of São João, 4200‑319 Porto, Portugal
Article Number: 71
|
Published online on: February 1, 2022

https://doi.org/10.3892/mco.2022.2504
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Abstract

Pleuroparenchymal fibroelastosis (PPFE) is a rare and recently described distinct pattern of lung apical fibrosis involving the upper lobe parenchyma and pleural dome. PPFE has definable and reproducible clinical, radiological and histopathological criteria, which allowed its classification as an independent interstitial lung disease. Several factors have been associated with PPFE, such as chemotherapy, especially with alkylating agents. The authors present a case of a 34‑year‑old female with previous history of Hodgkin lymphoma treated with first line chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine). The patient had no other known comorbidities or relevant exposure to lung irritants. A total of 2 years after completing cancer treatment, the patient developed clinical and radiological features of PPFE. Given their previous history of malignancy, a biopsy of the lesion was obtained, which confirmed the diagnosis of PPFE. The authors present this case to raise awareness of this disease and to demonstrate that PPFE can develop months to years following chemotherapy treatment. Moreover, to date, none of these chemotherapy agents have been associated with the development of PPFE.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pleuroparenchymal fibroelastosis as a complication of chemotherapy: A case report

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