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Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the CRTC1‑MAML2 fusion gene

  • Authors:
    • Kazuma Noguchi
    • Shuji Kanda
    • Kazunari Yoshida
    • Yusuke Funaoka
    • Koji Yamanegi
    • Kyohei Yoshikawa
    • Kazuki Takaoka
    • Hiromitsu Kishimoto
    • Yoshiro Nakano
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan, Department of Genetics, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan
    Copyright: © Noguchi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 75
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    Published online on: February 2, 2022
       https://doi.org/10.3892/mco.2022.2508
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Abstract

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the major and minor salivary glands. Surgical resection is the only curative treatment and there is no effective post‑operative therapy for MEC. The present study reports an Institutional Review Board‑approved case of a 45‑year‑old Japanese female diagnosed with low-grade MEC in the hard palate. Radical resection, supraomohyoid neck dissection and antero‑lateral thigh flap reconstruction was performed. A MEC cell line was then established from the resected tumor tissue. Short tandem repeat profiling confirmed the origin and authenticity of the cell line, that harbors a CRTC1‑MAML2 translocation, which is frequently observed in MEC. Amphiregulin (AREG), identified as one of the targets of the CRTC1‑MAML2 fusion gene, was expressed in the cell line. The AREG receptor, epidermal growth factor receptor (EGFR) was also highly phosphorylated. The results predicted that AREG‑EGFR signaling, which is required for tumor growth and survival, might be activated in the cell line in a cell‑autonomous manner. As AREG expression is associated with EGFR‑targeted drug resistance, this cell line might assist with the identification of novel strategies for MEC treatment.
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1 

Sentani K, Ogawa I, Ozawa K, Sadakane A, Utada M, Tsuya T, Kajihara H, Yonehara S, Takeshima Y and Yasui W: Characteristics of 5015 salivary gland neoplasms registered in the Hiroshima tumor tissue registry over a period of 39 years. J Clin Med. 8(566)2019.PubMed/NCBI View Article : Google Scholar

2 

Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Mäkitie A, Grenman R, et al: Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer. 45:470–481. 2006.PubMed/NCBI View Article : Google Scholar

3 

Ettl T, Schwarz-Furlan S, Gosau M and Reichert TE: Salivary gland carcinomas. Oral Maxillofac Surg. 16:267–283. 2012.PubMed/NCBI View Article : Google Scholar

4 

Katabi N, Ghossein R, Ali S, Dogan S, Klimstra D and Ganly I: Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading. Histopathology. 65:793–804. 2014.PubMed/NCBI View Article : Google Scholar

5 

El-Naggar AK, Lovell M, Killary AM, Clayman GL and Batsakis JG: A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet. 87:29–33. 1996.PubMed/NCBI View Article : Google Scholar

6 

Saade RE, Bell D, Garcia J, Roberts D and Weber R: Role of CRTC1/MAML2 translocation in the prognosis and clinical outcomes of mucoepidermoid carcinoma. JAMA Otolaryngol Head Neck Surg. 142:234–240. 2016.PubMed/NCBI View Article : Google Scholar

7 

Bell D and El-Naggar AK: Molecular heterogeneity in mucoepidermoid carcinoma: Conceptual and practical implications. Head Neck Pathol. 7:23–27. 2013.PubMed/NCBI View Article : Google Scholar

8 

Jee KJ, Persson M, Heikinheimo K, Passador-Santos F, Aro K, Knuutila S, Odell EW, Mäkitie A, Sundelin K, Stenman G and Leivo I: Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. Mod Pathol. 26:213–222. 2013.PubMed/NCBI View Article : Google Scholar

9 

O'Neill ID: t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. Oral Oncol. 45:2–9. 2009.PubMed/NCBI View Article : Google Scholar

10 

Seethala RR, Dacic S, Cieply K, Kelly LM and Nikiforova MN: A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas. Am J Surg Pathol. 34:1106–1121. 2010.PubMed/NCBI View Article : Google Scholar

11 

Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, et al: t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 33:208–213. 2003.PubMed/NCBI View Article : Google Scholar

12 

Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J and Stenman G: Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. Exp Cell Res. 292:21–28. 2004.PubMed/NCBI View Article : Google Scholar

13 

Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H and Griffin JD: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J. 24:2391–2402. 2005.PubMed/NCBI View Article : Google Scholar

14 

Coxon A, Rozenblum E, Park YS, Joshi N, Tsurutani J, Dennis PA, Kisch IR and Kaye FJ: Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. Cancer Res. 65:7137–7144. 2005.PubMed/NCBI View Article : Google Scholar

15 

Fehr A, Röser K, Heidorn K, Hallas C, Löning T and Bullerdiek J: A new type of MAML2 fusion in mucoepidermoid carcinoma. Genes Chromosomes Cancer. 47:203–206. 2008.PubMed/NCBI View Article : Google Scholar

16 

Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, et al: MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. Clin Cancer Res. 12:3902–3907. 2006.PubMed/NCBI View Article : Google Scholar

17 

Nakayama T, Miyabe S, Okabe M, Sakuma H, Ijichi K, Hasegawa Y, Nagatsuka H, Shimozato K and Inagaki H: Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma. Mod Pathol. 22:1575–1581. 2009.PubMed/NCBI View Article : Google Scholar

18 

Chen Z, Chen J, Gu Y, Hu C, Li JL, Lin S, Shen H, Cao C, Gao R, Li J, et al: Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells. Oncogene. 33:3869–3877. 2014.PubMed/NCBI View Article : Google Scholar

19 

Dahse R, Driemel O, Schwartz S, Dahse J, Kromeyer-Hauschild K, Berndt A and Kosmehl H: Epidermal growth factor receptor kinase domain mutations are rare in salivary gland carcinomas. Br J Cancer. 100:623–625. 2009.PubMed/NCBI View Article : Google Scholar

20 

Nakano T, Yamamoto H, Hashimoto K, Tamiya S, Shiratsuchi H, Nakashima T, Nishiyama K, Higaki Y, Komune S and Oda Y: HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status. Histopathology. 63:378–392. 2013.PubMed/NCBI View Article : Google Scholar

21 

Warner KA, Adams A, Bernardi L, Nor C, Finkel KA, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, et al: Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral Onco. 49:1059–1066. 2013.PubMed/NCBI View Article : Google Scholar

22 

Liu X, Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, et al: ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol. 180:599–607. 2012.PubMed/NCBI View Article : Google Scholar

23 

Dulbecco R and Vogt M: Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med. 99:167–182. 1954.PubMed/NCBI View Article : Google Scholar

24 

Noguchi K, Wakai K, Kiyono T, Kawabe M, Yoshikawa K, Hashimoto-Tamaoki T, Kishimoto H and Nakano Y: Molecular analysis of keratocystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients. Int J Oncol. 51:1731–1738. 2017.PubMed/NCBI View Article : Google Scholar

25 

Hiromoto T, Noguchi K, Yamamura M, Zushi Y, Segawa E, Takaoka K, Moridera K, Kishimoto H and Urade M: Up-regulation of neutrophil gelatinase-associated lipocalin in oral squamous cell carcinoma: Relation to cell differentiation. Oncol Rep. 26:1415–1421. 2011.PubMed/NCBI View Article : Google Scholar

26 

Gupta R, Kalita P, Patil O and Mohanty S: An investigation of folic acid-protein association sites and the effect of this association on folic acid self-assembly. J Mol Model. 21(308)2015.PubMed/NCBI View Article : Google Scholar

27 

Rio DC, Ares M Jr, Hannon GJ and Nilsen TW: Purification of RNA using TRIzol (TRI reagent). Cold Spring Harb Protoc. 2010(pdb.prot5439)2010.PubMed/NCBI View Article : Google Scholar

28 

Prophet EB, Mills B, Arrington JB and Sobin LH: Laboratory methods in histotechnology (Armed Forces Institute of Phatology). American Registry of Pathology, Washington, DC, 1992.

29 

Seethala RR: An update on grading of salivary gland carcinomas. Head Neck Pathol. 3:69–77. 2009.PubMed/NCBI View Article : Google Scholar

30 

Ohnishi Y, Minamino Y, Kakudo K and Nozaki M: Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency. Oncol Rep. 32:780–786. 2014.PubMed/NCBI View Article : Google Scholar

31 

Meng C, Wang S and Wang X, Lv J, Zeng W, Chang R, Li Q and Wang X: Amphiregulin inhibits TNF-α-induced alveolar epithelial cell death through EGFR signaling pathway. Biomed Pharmacother. 125(109995)2020.PubMed/NCBI View Article : Google Scholar

32 

Telesco SE, Vadigepalli R and Radhakrishnan R: Molecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype. Biotechnol J. 8:1452–1464. 2013.PubMed/NCBI View Article : Google Scholar

33 

Li X, Huang Q, Wang S, Huang Z, Yu F and Lin J: HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway. Acta Biochim Biophys Sin (Shanghai). 52:345–362. 2020.PubMed/NCBI View Article : Google Scholar

34 

Luna MA: Salivary mucoepidermoid carcinoma: Revisited. Adv Anat Pathol. 13:293–307. 2006.PubMed/NCBI View Article : Google Scholar

35 

Mitra A, Mishra L and Li S: Technologies for deriving primary tumor cells for use in personalized cancer therapy. Trends Biotechnol. 31:347–354. 2013.PubMed/NCBI View Article : Google Scholar

36 

Okumura Y, Miyabe S, Nakayama T, Fujiyoshi Y, Hattori H, Shimozato K and Inagaki H: Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma. Histopathology. 59:90–97. 2011.PubMed/NCBI View Article : Google Scholar

37 

Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG and El-Naggar AK: CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: Implications for histogenesis and biologic behavior. Genes Chromosomes Cancer. 46:708–715. 2007.PubMed/NCBI View Article : Google Scholar

38 

Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK and Kaye FJ: Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions. Genes Chromosomes Cancer. 49:59–69. 2010.PubMed/NCBI View Article : Google Scholar

39 

Komiya T, Park Y, Modi S, Coxon AB, Oh H and Kaye FJ: Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation. Oncogene. 25:6128–6132. 2006.PubMed/NCBI View Article : Google Scholar

40 

Wu J, Wang N, Yang Y, Jiang G, Zhan H and Li F: LINC01152 upregulates MAML2 expression to modulate the progression of glioblastoma multiforme via Notch signaling pathway. Cell Death Dis. 12(115)2021.PubMed/NCBI View Article : Google Scholar

41 

Amelio AL, Fallahi M, Schaub FX, Zhang M, Lawani MB, Alperstein AS, Southern MR, Young BM, Wu L, Zajac-Kaye M, et al: CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement. Proc Natl Acad Sci USA. 111:3260–3268. 2014.PubMed/NCBI View Article : Google Scholar

42 

Shinomiya H, Ito Y, Kubo M, Yonezawa K, Otsuki N, Iwae S, Inagaki H and Nibu KI: Expression of amphiregulin in mucoepidermoid carcinoma of the major salivary glands: A molecular and clinicopathological study. Hum Pathol. 57:37–44. 2016.PubMed/NCBI View Article : Google Scholar

43 

Porcheri C and Mitsiadis TA: Physiology, pathology and regeneration of salivary glands. Cells. 8(976)2019.PubMed/NCBI View Article : Google Scholar

44 

Weng PL, Aure MH, Maruyama T and Ovitt CE: Limited regeneration of adult salivary glands after severe injury involves cellular plasticity. Cell Rep. 24:1464–1470.e3. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Noguchi K, Kanda S, Yoshida K, Funaoka Y, Yamanegi K, Yoshikawa K, Takaoka K, Kishimoto H and Nakano Y: Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene. Mol Clin Oncol 16: 75, 2022.
APA
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K. ... Nakano, Y. (2022). Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene. Molecular and Clinical Oncology, 16, 75. https://doi.org/10.3892/mco.2022.2508
MLA
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K., Takaoka, K., Kishimoto, H., Nakano, Y."Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene". Molecular and Clinical Oncology 16.3 (2022): 75.
Chicago
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K., Takaoka, K., Kishimoto, H., Nakano, Y."Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene". Molecular and Clinical Oncology 16, no. 3 (2022): 75. https://doi.org/10.3892/mco.2022.2508
Copy and paste a formatted citation
x
Spandidos Publications style
Noguchi K, Kanda S, Yoshida K, Funaoka Y, Yamanegi K, Yoshikawa K, Takaoka K, Kishimoto H and Nakano Y: Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene. Mol Clin Oncol 16: 75, 2022.
APA
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K. ... Nakano, Y. (2022). Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene. Molecular and Clinical Oncology, 16, 75. https://doi.org/10.3892/mco.2022.2508
MLA
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K., Takaoka, K., Kishimoto, H., Nakano, Y."Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene". Molecular and Clinical Oncology 16.3 (2022): 75.
Chicago
Noguchi, K., Kanda, S., Yoshida, K., Funaoka, Y., Yamanegi, K., Yoshikawa, K., Takaoka, K., Kishimoto, H., Nakano, Y."Establishment of a patient‑derived mucoepidermoid carcinoma cell line with the <em>CRTC1‑MAML2</em> fusion gene". Molecular and Clinical Oncology 16, no. 3 (2022): 75. https://doi.org/10.3892/mco.2022.2508
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