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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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April-2022 Volume 16 Issue 4

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Case Report Open Access

Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report

  • Authors:
    • P. Gouveris
    • E.A. Georgakopoulou
    • A. Grigoraki
    • D.N. Zouki
    • V.E. Kardara
    • S. Ioannou
    • D. Tryfonopoulos
    • S. Demiri
    • I. Gkouveris
  • View Affiliations / Copyright

    Affiliations: Second Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece, Laboratory of Histology‑Embryology Molecular Carcinogenesis Group, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece, Department of Oral and Maxillofacial Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
    Copyright: © Gouveris et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 79
    |
    Published online on: February 8, 2022
       https://doi.org/10.3892/mco.2022.2512
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Abstract

Lichenoid granulomatous reactions (LGR) are granulomatous inflammations of the skin and oral mucosa, also sharing features of lichenoid lesions. Thus, the present study refers to lichenoid granulomatous dermatitis (LGD) and lichenoid granulomatous stomatitis (LGS). LGR is a condition that can be triggered by drugs, diseases or environmental causes. In the present case study, anti‑PD1 (nivolumab) medication had a detrimental effect on the oral mucosa, which clinicaly and histologicaly proved to be LGS. Checkpoint inhibitors consitute a cornerstone in the current treatment of several types of cancer, of which cutaneous melanoma is the best example. Oral lichenoid responses following anti‑PD‑1 therapy have been recorded in few case reports and small case series. To the best of our knowledhe, this is the first case of LGS being reported as a side effect of immune checkpoint inhibitor treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Gouveris P, Georgakopoulou E, Grigoraki A, Zouki D, Kardara V, Ioannou S, Tryfonopoulos D, Demiri S and Gkouveris I: Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report. Mol Clin Oncol 16: 79, 2022.
APA
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S. ... Gkouveris, I. (2022). Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report. Molecular and Clinical Oncology, 16, 79. https://doi.org/10.3892/mco.2022.2512
MLA
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S., Tryfonopoulos, D., Demiri, S., Gkouveris, I."Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report". Molecular and Clinical Oncology 16.4 (2022): 79.
Chicago
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S., Tryfonopoulos, D., Demiri, S., Gkouveris, I."Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report". Molecular and Clinical Oncology 16, no. 4 (2022): 79. https://doi.org/10.3892/mco.2022.2512
Copy and paste a formatted citation
x
Spandidos Publications style
Gouveris P, Georgakopoulou E, Grigoraki A, Zouki D, Kardara V, Ioannou S, Tryfonopoulos D, Demiri S and Gkouveris I: Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report. Mol Clin Oncol 16: 79, 2022.
APA
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S. ... Gkouveris, I. (2022). Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report. Molecular and Clinical Oncology, 16, 79. https://doi.org/10.3892/mco.2022.2512
MLA
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S., Tryfonopoulos, D., Demiri, S., Gkouveris, I."Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report". Molecular and Clinical Oncology 16.4 (2022): 79.
Chicago
Gouveris, P., Georgakopoulou, E., Grigoraki, A., Zouki, D., Kardara, V., Ioannou, S., Tryfonopoulos, D., Demiri, S., Gkouveris, I."Nivolumab‑induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report". Molecular and Clinical Oncology 16, no. 4 (2022): 79. https://doi.org/10.3892/mco.2022.2512
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