Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
April-2022 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2022 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report

  • Authors:
    • Federica Medici
    • Giambattista Siepe
    • Lidia Strigari
    • Francesco Massari
    • Milly Buwenge
    • Silvia Bisello
    • Paolo Castellucci
    • Stefano Fanti
    • Silvia Cammelli
    • Alessio Giuseppe Morganti
  • View Affiliations / Copyright

    Affiliations: Radiation Oncology Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum Bologna University, I-40138 Bologna, Italy, Radiation Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero‑Universitaria di Bologna, I-40138 Bologna, Italy, Medical Physics Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero‑Universitaria di Bologna, I-40138 Bologna, Italy, Medical Oncology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero‑Universitaria di Bologna, I-40138 Bologna, Italy, Nuclear Medicine Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero‑Universitaria di Bologna, I-40138 Bologna, Italy
    Copyright: © Medici et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 85
    |
    Published online on: February 18, 2022
       https://doi.org/10.3892/mco.2022.2518
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to report the case of a 58‑year‑old male patient with ureteral carcinoma who underwent ureteroileostomy treatment. At 2 years following surgery, six lymph node metastases (LNMs) were detected in the patient's para‑aortic and pelvic regions using 18F‑labeled fluoro‑2‑deoxyglucose (FDG) positron emission tomography (PET)/CT. All LNMs were treated using stereotactic body radiotherapy (SBRT; 35‑40 Gy/5 fractions). At 3 months after radiotherapy, 18F‑FDG‑PET/CT examination revealed a complete radiological and metabolic response of all targeted treatment sites in the patient. In the 2 years following radiotherapy, another three same‑dose SBRT treatments were performed on single or multiple LNMs, which were all detected in the abdomen and pelvis of the patient. Overall, a total of 11 LNMs were targeted in the patient and all exhibited complete radiological and metabolic response following treatment. The only treatment side effect reported by the patient was a slight and temporary loss of appetite. In patients with lymph node oligometastases there are two options for radiotherapy: i) Irradiation focusing on LNMs alone; and ii) prophylactic irradiation of the entire lymph node area combined with a boost on macroscopic lesions. In the patient discussed in the present study, the choice of irradiation focusing on LNMs alone made it possible to postpone systemic therapies and instead use an optimally tolerated treatment. The treatment outcome in this patient indicated that there was no radioresistance of urothelial LNMs.
View Figures

Figure 1

Figure 2

View References

1 

Rouprêt M, Babjuk M, Compérat E, Zigeuner R, Sylvester RJ, Burger M, Cowan NC, Böhle A, Van Rhijn BW, Kaasinen E, et al: European association of urology guidelines on upper urinary tract urothelial cell carcinoma: 2015 update. Eur Urol. 68:868–879. 2015.PubMed/NCBI View Article : Google Scholar

2 

Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR (eds), et al: SEER Cancer Statistics Review 1975-2015. National Cancer Institute, Bethesda, MD, 2018.

3 

Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Clark PE, Downs TM, Efstathiou JA, Flaig TW, Friedlander T, et al: Bladder Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 15:1240–1267. 2017.PubMed/NCBI View Article : Google Scholar

4 

Siefker-Radtke AO, Walsh GL, Pisters LL, Shen Y, Swanson DA, Logothetis CJ and Millikan RE: Is there a role for surgery in the management of metastatic urothelial cancer? The M. D. Anderson experience. J Urol. 171:145–148. 2004.PubMed/NCBI View Article : Google Scholar

5 

Lehmann J, Suttmann H, Albers P, Volkmer B, Gschwend JE, Fechner G, Spahn M, Heidenreich A, Odenthal A, Seif C, et al: Surgery for metastatic urothelial carcinoma with curative intent: The German experience (AUO AB 30/05). Eur Urol. 55:1293–1299. 2009.PubMed/NCBI View Article : Google Scholar

6 

Dodd PM, McCaffrey JA, Herr H, Mazumdar M, Bacik J, Higgins G, Boyle MG, Scher HI and Bajorin DF: Outcome of postchemotherapy surgery after treatment with methotrexate, vinblastine, doxorubicin, and cisplatin in patients with unresectable or metastatic transitional cell carcinoma. J Clin Oncol. 17:2546–2552. 1999.PubMed/NCBI View Article : Google Scholar

7 

Abe T, Shinohara N, Harabayashi T, Sazawa A, Maruyama S, Suzuki S and Nonomura K: Impact of multimodal treatment on survival in patients with metastatic urothelial cancer. Eur Urol. 52:1106–1113. 2007.PubMed/NCBI View Article : Google Scholar

8 

Deodato F, Ferro M, Cilla S, Ianiro A, Buwenge M, Re A, Sallustio G, Valentini V, Morganti AG and Macchia G: Stereobody radiotherapy for nodal recurrences in oligometastatic patients: A pooled analysis from two phase I clinical trials. Clin Exp Metastasis. 37:519–529. 2020.PubMed/NCBI View Article : Google Scholar

9 

Riley DS, Barber MS, Kienle GS, Aronson JK, von Schoen-Angerer T, Tugwell P, Kiene H, Helfand M, Altman DG, Sox H, et al: CARE guidelines for case reports: Explanation and elaboration document. J Clin Epidemiol. 89:218–235. 2017.PubMed/NCBI View Article : Google Scholar

10 

Brierley JD, Gospodarowicz MK and Wittekind C (eds): TNM Classification of Malignant Tumours. 8th edition. John Wiley & Sons, Inc. Hoboken, NJ, pp1-272, 2017.

11 

Compérat EM, Burger M, Gontero P, Mostafid AH, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Sylvester RJ, Zigeuner R and Babjuk M: Grading of urothelial carcinoma and the new ‘World health organisation classification of tumours of the urinary system and male genital organs 2016’. Eur Urol Focus. 5:457–466. 2019.PubMed/NCBI View Article : Google Scholar

12 

Margulis V, Shariat SF, Matin SF, Kamat AM, Zigeuner R, Kikuchi E, Lotan Y, Weizer A, Raman JD and Wood CG: Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration. Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer. 115:1224–1233. 2009.PubMed/NCBI View Article : Google Scholar

13 

Hellman S and Weichselbaum RR: Oligometastases. J Clin Oncol. 13:8–10. 1995.PubMed/NCBI View Article : Google Scholar

14 

Loi M, Frelinghuysen M, Klass ND, Oomen-De Hoop E, Granton PV, Aerts J, Verhoef C and Nuyttens J: Locoregional control and survival after lymph node SBRT in oligometastatic disease. Clin Exp Metastasis. 35:625–633. 2018.PubMed/NCBI View Article : Google Scholar

15 

Francolini G, Desideri I, Detti B, Di Cataldo V, Masi L, Caramia G, Visani L, Terziani F, Muntoni C, Lo Russo M, et al: Stereotactic radiotherapy in oligoprogressive and oligorecurrent urothelial cancer patients: A retrospective experience. Cancer Treat Res Commun. 19(100124)2019.PubMed/NCBI View Article : Google Scholar

16 

Deodato F, Macchia G, Buwenge M, Bonetti M, Cilla S, Zamagni A, Re A, Pezzulla D, Cellini F, Strigari L, et al: Systematic review of stereotactic body radiotherapy for nodal metastases. Clin Exp Metastasis. 38:11–29. 2021.PubMed/NCBI View Article : Google Scholar

17 

Seo YS, Kim MS, Cho CK, Yoo HJ, Jang WI, Kim KB, Lee DH, Moon SM and Lee HR: Stereotactic body radiotherapy for oligometastases confined to the para-aortic region: Clinical outcomes and the significance of radiotherapy field and dose. Cancer Invest. 33:180–187. 2015.PubMed/NCBI View Article : Google Scholar

18 

Kneebone A, Hruby G, Ainsworth H, Byrne K, Brown C, Guo L, Guminski A and Eade T: Stereotactic body radiotherapy for oligometastatic prostate cancer detected via prostate-specific membrane antigen positron emission tomography. Eur Urol Oncol. 1:531–537. 2018.PubMed/NCBI View Article : Google Scholar

19 

Detti B, D'Angelillo RM, Ingrosso G, Olmetto E, Francolini G, Triggiani L, Bruni A, Borghesi S, Fondelli S, Carfagno T, et al: Combining abiraterone and radiotherapy in prostate cancer patients who progressed during abiraterone therapy. Anticancer Res. 37:3717–3722. 2017.PubMed/NCBI View Article : Google Scholar

20 

Sundahl N, Vandekerkhove G, Decaestecker K, Meireson A, De Visschere P, Fonteyne V, De Maeseneer D, Reynders D, Goetghebeur E, Van Dorpe J, et al: Randomized phase 1 trial of pembrolizumab with sequential versus concomitant stereotactic body radiotherapy in metastatic urothelial carcinoma. Eur Urol. 75:707–711. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Medici F, Siepe G, Strigari L, Massari F, Buwenge M, Bisello S, Castellucci P, Fanti S, Cammelli S, Morganti AG, Morganti AG, et al: CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Mol Clin Oncol 16: 85, 2022.
APA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S. ... Morganti, A.G. (2022). CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Molecular and Clinical Oncology, 16, 85. https://doi.org/10.3892/mco.2022.2518
MLA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16.4 (2022): 85.
Chicago
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16, no. 4 (2022): 85. https://doi.org/10.3892/mco.2022.2518
Copy and paste a formatted citation
x
Spandidos Publications style
Medici F, Siepe G, Strigari L, Massari F, Buwenge M, Bisello S, Castellucci P, Fanti S, Cammelli S, Morganti AG, Morganti AG, et al: CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Mol Clin Oncol 16: 85, 2022.
APA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S. ... Morganti, A.G. (2022). CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Molecular and Clinical Oncology, 16, 85. https://doi.org/10.3892/mco.2022.2518
MLA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16.4 (2022): 85.
Chicago
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16, no. 4 (2022): 85. https://doi.org/10.3892/mco.2022.2518
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team