Open Access

CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report

  • Authors:
    • Federica Medici
    • Giambattista Siepe
    • Lidia Strigari
    • Francesco Massari
    • Milly Buwenge
    • Silvia Bisello
    • Paolo Castellucci
    • Stefano Fanti
    • Silvia Cammelli
    • Alessio Giuseppe Morganti
  • View Affiliations

  • Published online on: February 18, 2022     https://doi.org/10.3892/mco.2022.2518
  • Article Number: 85
  • Copyright: © Medici et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to report the case of a 58‑year‑old male patient with ureteral carcinoma who underwent ureteroileostomy treatment. At 2 years following surgery, six lymph node metastases (LNMs) were detected in the patient's para‑aortic and pelvic regions using 18F‑labeled fluoro‑2‑deoxyglucose (FDG) positron emission tomography (PET)/CT. All LNMs were treated using stereotactic body radiotherapy (SBRT; 35‑40 Gy/5 fractions). At 3 months after radiotherapy, 18F‑FDG‑PET/CT examination revealed a complete radiological and metabolic response of all targeted treatment sites in the patient. In the 2 years following radiotherapy, another three same‑dose SBRT treatments were performed on single or multiple LNMs, which were all detected in the abdomen and pelvis of the patient. Overall, a total of 11 LNMs were targeted in the patient and all exhibited complete radiological and metabolic response following treatment. The only treatment side effect reported by the patient was a slight and temporary loss of appetite. In patients with lymph node oligometastases there are two options for radiotherapy: i) Irradiation focusing on LNMs alone; and ii) prophylactic irradiation of the entire lymph node area combined with a boost on macroscopic lesions. In the patient discussed in the present study, the choice of irradiation focusing on LNMs alone made it possible to postpone systemic therapies and instead use an optimally tolerated treatment. The treatment outcome in this patient indicated that there was no radioresistance of urothelial LNMs.
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April-2022
Volume 16 Issue 4

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Spandidos Publications style
Medici F, Siepe G, Strigari L, Massari F, Buwenge M, Bisello S, Castellucci P, Fanti S, Cammelli S, Morganti AG, Morganti AG, et al: CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Mol Clin Oncol 16: 85, 2022
APA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S. ... Morganti, A.G. (2022). CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report. Molecular and Clinical Oncology, 16, 85. https://doi.org/10.3892/mco.2022.2518
MLA
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16.4 (2022): 85.
Chicago
Medici, F., Siepe, G., Strigari, L., Massari, F., Buwenge, M., Bisello, S., Castellucci, P., Fanti, S., Cammelli, S., Morganti, A. G."CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report". Molecular and Clinical Oncology 16, no. 4 (2022): 85. https://doi.org/10.3892/mco.2022.2518