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Review

Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review)

  • Authors:
    • Erika Rijavec
    • Federica Biello
    • Giulia Barletta
    • Chiara Dellepiane
    • Carlo Genova
  • View Affiliations / Copyright

    Affiliations: Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, I‑20122 Milan, Italy, Department of Translational Medicine, Division of Oncology, University of Eastern Piemonte, I‑28100 Novara, Italy, Medical Oncology Unit, IRCCS Ospedale Policlinico San Martino, I‑16132 Genoa, Italy, Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, I‑16132 Genoa, Italy
  • Article Number: 89
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    Published online on: February 22, 2022
       https://doi.org/10.3892/mco.2022.2522
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Abstract

Malignant pleural mesothelioma (MPM) is considered a relatively uncommon disease but its incidence is increasing worldwide. Patients affected by MPM have a very severe prognosis and have been often occupationally and environmentally exposed to asbestos. In recent years, checkpoint inhibitors have dramatically revolutionized the paradigm for the treatment of several malignancies. Several efforts have also been made to improve the survival outcomes of patients with MPM and after decades, the standard‑of‑care systemic treatment for unresectable MPM, based on first‑line combination chemotherapy with cisplatin and pemetrexed, has changed. In addition to checkpoint inhibitors, other types of treatments, such as molecularly targeted therapy have been evaluated. However, to date, the results of these investigations are not very encouraging. The aim of the present review is to provide a comprehensive overview of the most relevant data of clinical trials regarding recent treatment strategies of MPM with a particular focus on immunotherapeutic and targeted approaches.
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1 

Davis AP, Kao SC, Clarke SJ, Boyer M and Pavlakis N: Emerging biological therapies for the treatment of malignant pleural mesothelioma. Expert Opin Emerg Drugs. 26:179–192. 2021.PubMed/NCBI View Article : Google Scholar

2 

Parker C and Neville E: Lung cancer * 8: Management of malignant mesothelioma. Thorax. 58:809–813. 2003.PubMed/NCBI View Article : Google Scholar

3 

Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, et al: Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the International mesothelioma interest group. Arch Pathol Lab Med. 142:89–108. 2018.PubMed/NCBI View Article : Google Scholar

4 

Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, et al: First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): A multicentre, randomised, open-label, phase 3 trial. Lancet. 397:375–386. 2021.PubMed/NCBI View Article : Google Scholar

5 

Scherpereel A, Antonia S, Bautista Y, Grossi F, Kowalski D, Zalcman G, Nowak A, Fujimoto N, Peters S, Tsao A, et al: First-line nivolumab (NIVO) plus ipilimumab (IPI) versus chemotherapy (chemo) for the treatment of unresectable malignant pleural mesothelioma (MPM): Patient-reported outcomes (PROs) from CheckMate 743. Ann Oncol. 31 (Suppl 7)(S1441)2020.

6 

Wright K: FDA approves nivolumab plus ipilimumab for previously untreated unresectable malignant pleural mesothelioma. Oncology (Williston Park). 34:502–503. 2020.PubMed/NCBI View Article : Google Scholar

7 

Peters S, Scherpereel A, Cornelissen R, Oulkhouir Y, Greillier L, Kaplan MA, Talbot T, Monnet I, Hiret S, Baas P, et al: First-line nivolumab (NIVO) plus ipilimumab (IPI) vs chemotherapy (chemo) in patients (pts) with unresectable malignant pleural mesothelioma (MPM): 3-year update from CheckMate 743. Ann Oncol. 32 (Suppl 5):S1283–S1346. 2021.PubMed/NCBI View Article : Google Scholar

8 

Forde PM, Sun Z, Anagnostou V, Kindler HL, Purcell WT, Goulart BHL, Dudek AZ, Borghaei H, Brahmer JR and Ramalingam SS: PrE0505: Phase II multicenter study of anti-PD-L1, durvalumab, in combination with cisplatin and pemetrexed for the first-line treatment of unresectable malignant pleural mesothelioma (MPM)-A PrECOG LLC study. J Clin Oncol. 38 (Suppl 15)(S9003)2020.

9 

Nowak AK, Lesterhuis WJ, Kok PS, Brown C, Hughes BG, Karikios DJ, John T, Kao SC, Leslie C, Cook AM, et al: Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): A multicentre, single-arm, phase 2 trial with a safety run-in. Lancet Oncol. 21:1213–1223. 2020.PubMed/NCBI View Article : Google Scholar

10 

Forde PM, Nowak AK, Kok PS, Brown C, Sun Z, Anagnostou V, O'Byrne KJ, Yip S, Cook A, Lesterhuis WJ, et al: DREAM3R: Durvalumab with chemotherapy as first-line treatment in advanced pleural mesothelioma-a phase 3 randomized trial. J Chin Oncol. 39(TPS8586)2021.PubMed/NCBI View Article : Google Scholar

11 

Quispel-Janssen J, van der Noort V, de Vries JF, Zimmerman M, Lalezari F, Thunnissen E, Monkhorst K, Schouten R, Schunselaar L, Disselhorst M, et al: Programmed Death 1 Blockade with nivolumab in patients with recurrent malignant pleural mesothelioma. J Thorac Oncol. 13:1569–1576. 2018.PubMed/NCBI View Article : Google Scholar

12 

Okada M, Kijima T, Aoe K, Kato T, Fujimoto N, Nakagawa K, Takeda Y, Hida T, Kanai K, Imamura F, et al: Clinical efficacy and safety of nivolumab: Results of a multicenter, open-label, single-arm, Japanese phase II study in malignant pleural mesothelioma (MERIT). Clin Cancer Res. 18:5485–5492. 2019.PubMed/NCBI View Article : Google Scholar

13 

Hayashi H, Okada M, Kijima T, Aoe K, Kato T, Fujimoto N, Nakagawa K, Takeda Y, Hida T, Kanai K, et al: Three-year follow-up results of the MERIT trial: A Japanese phase II study of nivolumab in malignant pleural mesothelioma. Ann Oncol. 31(S1076)2020.

14 

Fennell DA, Kirkpatrick E, Cozens K, Nye M, Lester J, Hanna G, Steele N, Szlosarek P, Danson S, Lord J, et al: CONFIRM: A double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: Study protocol for a randomised controlled trial. Trials. 19(233)2018.PubMed/NCBI View Article : Google Scholar

15 

Fennell D, Ottensmeier C, Califano R, Hanna G, Ewings S, Hill K, Wilding S, Danson S, Nye M, Steele N, et al: Nivolumab versus placebo in relapsed malignant mesothelioma: The CONFIRM phase 3 trial. J Thorac Oncol. 16 (Suppl)(S62)2020.PubMed/NCBI View Article : Google Scholar

16 

Fennell DA, Ewings S, Ottensmeier C, Califano R, Hanna GG, Hill K, Danson S, Steele N, Nye M, Johnson L, et al: Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): A multicentre, double-blind, randomised, phase 3 trial. Lancet Oncol. 22:1530–1540. 2021.PubMed/NCBI View Article : Google Scholar

17 

Scherpereel A, Mazieres J, Greillier L, Lantuejoul S, Dô P, Bylicki O, Monnet I, Corre R, Audigier-Valette C, Locatelli-Sanchez M, et al: Nivolumab or nivolumab plus ipilimumab in patients with relapsed malignant pleural mesothelioma (IFCT-1501 MAPS2): A multicentre, open-label, randomised, non-comparative, phase 2 trial. Lancet Oncol. 20:239–253. 2019.PubMed/NCBI View Article : Google Scholar

18 

Zalcman G, Mazieres J, Greillier L, Brosseau S, Lantuejoul S, DO P, Bylicki O, Monnet I, Corre R, Audigier-Valette C, et al: 2nd/3rd-line nivolumab vs nivo plus ipilimumab in malignant pleural mesothelioma: long-term results of IFCT-1501 MAPS2 phase 2R trial with a focus on hyperprogression (HPD). Ann Oncol. 30 (Suppl 5):v747–v755. 2019.

19 

Disselhorst MJ, Quispel-Janssen J, Lalezari F, Monkhost K, de Vries JF, van der Noort V, Hams E, Burgers S and Baas P: Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): Results of a prospective, single-arm, phase 2 trial. Lancet Respir Med. 7:260–270. 2019.PubMed/NCBI View Article : Google Scholar

20 

Yap TA, Nakagawa K, Fujimoto N, Kuribayashi K, Guren TK, Calabro L, Shapira-Frommer R, Gao B, Kao S, Matos I, et al: Efficacy and safety of pembrolizumab in patients with advanced mesothelioma in the open-label, single-arm, phase 2 KEYNOTE-158 study. Lancet Respir Med. 9:613–621. 2021.PubMed/NCBI View Article : Google Scholar

21 

Popat S, Curioni-Fontecedro A, Dafni U, Shah R, O'Brien M, Pope A, Fisher P, Spicer J, Roy A, Gilligan D, et al: A multicentre randomised phase III trial comparing pembrolizumab versus single-agent chemotherapy for advanced pre-treated malignant pleural mesothelioma: The European thoracic oncology platform (ETOP 9-15) PROMISE-meso trial. Ann Oncol. 31:1734–1745. 2020.PubMed/NCBI View Article : Google Scholar

22 

Calabrò L, Morra A, Fonsatti E, Cutaia O, Amato G, Giannarelli D, Di Giacomo AM, Danielli R, Altomonte M, Mutti L and Maio M: Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-arm, phase 2 trial. Lancet Oncol. 14:1104–1111. 2013.PubMed/NCBI View Article : Google Scholar

23 

Calabrò L, Morra A, Fonsatti E, Cutaia O, Fazio C, Annesi D, Lenoci M, Amato G, Danielli R, Altomonte M, et al: Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study. Lancet Resp Med. 3:301–309. 2015.PubMed/NCBI View Article : Google Scholar

24 

Maio M, Scherpereel A, Calabrò L, Aerts J, Perez SC, Bearz A, Nackaerts K, Fennell DA, Kowalski D, Tsao AS, et al: Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): A multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial. Lancet Oncol. 18:1261–1273. 2017.PubMed/NCBI View Article : Google Scholar

25 

Calabrò L, Morra A, Giannarelli D, Amato G, D'Incecco A, Covre A, Lewis A, Rebelatto MC, Danielli R, Altomonte M, et al: Tremelimumab combined with durvalumab in patients with mesothelioma (NIBIT-MESO-1): An open-label, non-randomised, phase 2 study. Lancet Respir Med. 6:451–460. 2018.PubMed/NCBI View Article : Google Scholar

26 

Calabrò L, Rossi G, Morra A, Rosati C, Cutaia O, Daffinà MG, Altomonte M, Di Giacomo AM, Casula M, Fazio C, et al: Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: A follow-up of the open-label, non randomised, phase 2 NIBIT-MESO-1 study. Lancet Respir Med. 9:969–976. 2021.PubMed/NCBI View Article : Google Scholar

27 

Venkatraman D, Anderson A, Digumarthy S, Lizotte PH and Awad MM: Phase 2 study of tremelimumab plus durvalumab for previously-treated malignant pleural mesothelioma (MPM). J Chin Oncol. 37 (Suppl 15):8549. 2019.

28 

Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL and Gill PS: Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int J Cancer. 104:603–610. 2003.PubMed/NCBI View Article : Google Scholar

29 

Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, et al: Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): A randomised, controlled, open-label, phase 3 trial. Lancet. 387:1405–1414. 2016.PubMed/NCBI View Article : Google Scholar

30 

Roth GJ, Binder R, Colbatzky F, Dallinger C, Schlenker-Herceg R, Hilberg F, Wollin SL and Kaiser R: Nintedanib: From discovery to the clinic. J Med Chem. 58:1053–1063. 2015.PubMed/NCBI View Article : Google Scholar

31 

Grosso F, Steele N, Novello S, Nowak AK, Popat S, Greillier L, John T, Leighl NB, Reck M, Taylor P, et al: Nintedanib plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma: Phase II results from the randomized, placebo-controlled LUME-Meso Trial. J Clin Oncol. 35:3591–3600. 2017.PubMed/NCBI View Article : Google Scholar

32 

Scagliotti GV, Gaafar R, Nowak AK, Nakano T, van Meerbeeck J, Popat S, Vogelzang NJ, Grosso F, Aboelhassan R, Jakopovic M, et al: Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): A double-blind, randomised, placebo-controlled phase 3 trial. Lancet Respir Med. 7:569–580. 2019.PubMed/NCBI View Article : Google Scholar

33 

Tsao AS, Miao J, Wistuba II, Vogelzang NJ, Heymach JV, Fossella FV, Lu C, Velasco MR, Box-Noriega B, Hueftle JG, et al: Phase II trial of cediranib in combination with cisplatin and pemetrexed in chemotherapy-naïve patients with unresectable malignant pleural mesothelioma (SWOG S0905). J Clin Oncol. 37:2537–2547. 2019.PubMed/NCBI View Article : Google Scholar

34 

Pinto C, Zucali PA, Pagano M, Grosso F, Pasello G, Garassino MC, Tiseo M, Soto Parra H, Grossi F, Cappuzzo F, et al: Gemcitabine with or without ramucirumab as second-line treatment for malignant pleural mesothelioma (RAMES): A randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Oncol. 22:1438–1447. 2021.PubMed/NCBI View Article : Google Scholar

35 

Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, et al: Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 20:5927–5936. 2014.PubMed/NCBI View Article : Google Scholar

36 

Hassan R, Sharon E, Thomas A, Zhang J, Ling A, Miettinen M, Kreitman RJ, Steinberg SM, Hollevoet K and Pastan I: Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125. Cancer. 120:3311–3319. 2014.PubMed/NCBI View Article : Google Scholar

37 

Kindler HL, Novello S, Fennell DA, Blumenschein G, Bearz A, Ceresoli G, Aerts J, Spicer J, Taylor P, Taylor P, et al: Randomized phase II study of anetumab ravtansine or vinorelbine in patients with malignant pleural mesothelioma. J Thorac Oncol. 12(S1746)2017.

38 

Sterner RC and Sterner RM: CAR-T cell therapy: Current limitations and potential strategies. Blood Cancer J. 11(69)2021.PubMed/NCBI View Article : Google Scholar

39 

Castelletti L, Yeo D, van Zandwijk N and Rasko JEJ: Anti-Mesothelin CAR T cell therapy for malignant mesothelioma. Biomark Res. 9(11)2021.PubMed/NCBI View Article : Google Scholar

40 

NCT01583686: CAR T cell receptor immunotherapy targeting mesothelin for patients with metastatic cancer. https://clinicaltrials.gov/ct2/show/NCT01583686.

41 

Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M and June CH: T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunol Res. 1:26–31. 2013.PubMed/NCBI

42 

Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, et al: Phase I study of lentiviral-transduced chimeric antigen receptor-modified t cells recognizing mesothelin in advanced solid cancers. Mol Ther. 27:1919–1929. 2019.PubMed/NCBI View Article : Google Scholar

43 

Chintala NK, Restle D, Quach H, Saini J, Bellis R, Offin M, Beattie J and Adusumilli PS: CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials. Lung Cancer. 157:48–59. 2021.PubMed/NCBI View Article : Google Scholar

44 

Adusumilli PS, Zauderer MG, Rivière I, Solomon SB, Rusch VW, O'Cearbhaill RE, Zhu A, Cheema W, Chintala NK, Halton E, et al: A Phase I trial of regional mesothelin-targeted CAR T-cell therapy in patients with malignant pleural disease, in combination with the anti-PD-1 agent pembrolizumab. Cancer Discov. 11:2748–2763. 2021.PubMed/NCBI View Article : Google Scholar

45 

Popat S, Baas P, Faivre-Finn C, Girard N, Nicholson AG, Nowak AK, Opitz I, Scherpereel A and Reck M: ESMO Guidelines Committee Electronic address: simpleclinicalguidelines@esmo.org. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 33:129–142. 2022.PubMed/NCBI View Article : Google Scholar

46 

NCCN: Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Malignant Pleural Mesothelioma version 1.2022-December22, 2021. https://www.nccn.org/professionals/physician_gls/pdf/mpm.pdf.

47 

Harber J, Kamata T, Pritchard C and Fennell D: Matter of TIME: The tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy. J Immunother Cancer. 9(e003032)2021.PubMed/NCBI View Article : Google Scholar

48 

van Zandwijk N, Clarke C, Henderson D, Musk AW, Fong K, Nowak A, Loneragan R, McCaughan B, Boyer M, Feigen M, et al: Guidelines for the diagnosis and treatment of malignant pleural mesothelioma. J Thorac Dis. 5:E254–E307. 2013.PubMed/NCBI View Article : Google Scholar

49 

Brockwell NK, Alamgeer M, Kumar B, Rivalland G, John T and Parker BS: Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma. Transl Lung Cancer Res. 9:639–645. 2020.PubMed/NCBI View Article : Google Scholar

50 

NCT03762018: BEAT-meso: bevacizumab and atezolizumab in malignant pleural mesothelioma. https://clinicaltrials.gov/ct2/show/NCT03762018.

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Copy and paste a formatted citation
Spandidos Publications style
Rijavec E, Biello F, Barletta G, Dellepiane C and Genova C: Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review). Mol Clin Oncol 16: 89, 2022.
APA
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., & Genova, C. (2022). Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review). Molecular and Clinical Oncology, 16, 89. https://doi.org/10.3892/mco.2022.2522
MLA
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., Genova, C."Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review)". Molecular and Clinical Oncology 16.4 (2022): 89.
Chicago
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., Genova, C."Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review)". Molecular and Clinical Oncology 16, no. 4 (2022): 89. https://doi.org/10.3892/mco.2022.2522
Copy and paste a formatted citation
x
Spandidos Publications style
Rijavec E, Biello F, Barletta G, Dellepiane C and Genova C: Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review). Mol Clin Oncol 16: 89, 2022.
APA
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., & Genova, C. (2022). Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review). Molecular and Clinical Oncology, 16, 89. https://doi.org/10.3892/mco.2022.2522
MLA
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., Genova, C."Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review)". Molecular and Clinical Oncology 16.4 (2022): 89.
Chicago
Rijavec, E., Biello, F., Barletta, G., Dellepiane, C., Genova, C."Novel approaches for the treatment of unresectable malignant pleural mesothelioma: A focus on immunotherapy and target therapy (Review)". Molecular and Clinical Oncology 16, no. 4 (2022): 89. https://doi.org/10.3892/mco.2022.2522
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