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Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab

  • Authors:
    • Sawako Tamaki
    • Hideki Ishikawa
    • Koichi Suzuki
    • Yasuaki Kimura
    • Ryo Maemoto
    • Iku Abe
    • Yuhei Endo
    • Nao Kakizawa
    • Fumiaki Watanabe
    • Kazushige Futsuhara
    • Masaaki Saito
    • Shingo Tsujinaka
    • Yasuyuki Miyakura
    • Toshiki Rikiyama
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan
    Copyright: © Tamaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
    |
    Published online on: April 12, 2022
       https://doi.org/10.3892/mco.2022.2536
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Abstract

Combined treatment with bevacizumab and trifluridine/tipiracil (TAS‑102) leads to an increased chance of survival in patients with refractory metastatic colorectal cancer (mCRC); however, this treatment is associated with an increased frequency of severe neutropenia (number of neutrophils <1,000), which should ideally be managed without dose delays. The present study provided a retrospective review of 35 patients with mCRC, and aimed to elucidate the benefits of prophylactic pegfilgrastim for the treatment of severe neutropenia. Patients received TAS‑102 (35 mg/m2) orally twice daily on days 1‑5 and 8‑12 of each 28‑day treatment cycle, along with intravenous bevacizumab (5 mg/kg) on days 1 and 15. Moreover, the patients received 3.6 mg pegfilgrastim on day 15 of each cycle. The incidence of adverse events (AEs), disease control rate (DCR), progression‑free survival (PFS) and overall survival (OS) were assessed. In the first and subsequent cycles, 23 and 12 patients, respectively, received pegfilgrastim. The most common AE experienced was grade 3/4 neutropenia (8 patients; 22.9%). Among these 8 patients, 6 (17.1%) and 3 (8.6%) exhibited neutropenia prior to receiving pegfilgrastim or following discontinuation of pegfilgrastim administration, respectively. Moreover, 1 individual among these 8 patients (2.9%) demonstrated grade 3 neutropenia both prior to receiving pegfilgrastim and following discontinuation of pegfilgrastim. A total of 2 patients (5.7%) exhibited grade 3 bone pain, which prevented sustainable administration of pegfilgrastim and resulted in grade 3 neutropenia. Dose delays and dose reduction of TAS‑102 due to neutropenia were required in 5 (14.3%) and 2 (5.7%) patients, respectively, during the treatment period. None of the patients exhibited severe neutropenia during chemotherapy after pegfilgrastim administration, thereby preventing dose delays and dose reduction of TAS‑102. The relative dose intensity was 96.8% (65.0‑100.0%), and the DCR was 54.3%. The median PFS and median OS were 4.4 and 14.9 months, respectively. In conclusion, prophylactic pegfilgrastim may facilitate the management of severe neutropenia without dose delays in patients with mCRC treated with TAS‑102 plus bevacizumab.
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1 

Tanaka N, Sakamoto K, Okabe H, Fujioka A, Yamamura K, Nakagawa F, Nagase H, Yokogawa T, Oguchi K, Ishida K, et al: Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. Oncol Rep. 32:2319–2326. 2014.PubMed/NCBI View Article : Google Scholar

2 

Fukushima M, Suzuki N, Emura T, Yano S, Kazuno H, Tada Y, Yamada Y and Asao T: Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides. Biochem Pharmacol. 59:1227–1236. 2000.PubMed/NCBI View Article : Google Scholar

3 

Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, Garcia-Carbonero R, Mizunuma N, Yamazaki K, Shimada Y, Tabernero J, Komatsu Y, et al: Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 372:1909–1919. 2015.PubMed/NCBI View Article : Google Scholar

4 

Crawford J, Dale DC and Lyman GH: Chemotherapy-induced neutropenia: Risks, consequences, and new directions for its management. Cancer. 100:228–237. 2004.PubMed/NCBI View Article : Google Scholar

5 

Lyman GH, Kuderer N, Greene J and Balducci L: The economics of febrile neutropenia: Implications for the use of colony-stimulating factors. Eur J Cancer. 34:1857–1864. 1998.PubMed/NCBI View Article : Google Scholar

6 

Lyman GH and Kuderer NM: Filgrastim in patients with neutropenia: Potential effects on quality of life. Drugs. 62 (Suppl 1):S65–S78. 2002.PubMed/NCBI View Article : Google Scholar

7 

Network NCC: National Comprehensive Cancer Network guidelines. 2022.

8 

Crawford J, Becker PS, Armitage JO, Blayney DW, Chavez J, Curtin P, Dinner S, Fynan T, Gojo I, Griffiths EA, et al: Myeloid growth factors, version 2.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:1520–1541. 2017.PubMed/NCBI View Article : Google Scholar

9 

Kuboki Y, Nishina T, Shinozaki E, Yamazaki K, Shitara K, Okamoto W, Kajiwara T, Matsumoto T, Tsushima T, Mochizuki N, et al: TAS-102 plus bevacizumab for patients with metastatic colorectal cancer refractory to standard therapies (C-TASK FORCE): An investigator-initiated, open-label, single-arm, multicentre, phase 1/2 study. Lancet Oncol. 18:1172–1181. 2017.PubMed/NCBI View Article : Google Scholar

10 

Morrison VA, Wong M, Hershman D, Campos LT, Ding B and Malin J: Observational study of the prevalence of febrile neutropenia in patients who received filgrastim or pegfilgrastim associated with 3-4 week chemotherapy regimens in community oncology practices. J Manag Care Pharm. 13:337–348. 2007.PubMed/NCBI View Article : Google Scholar

11 

Pinter T, Klippel Z, Cesas A, Croitoru A, Decaestecker J, Gibbs P, Hotko Y, Jassem J, Kurteva G, Novotny J, et al: A phase III, randomized, double-blind, placebo-controlled trial of pegfilgrastim in patients receiving first-line FOLFOX/bevacizumab or FOLFIRI/bevacizumab for locally advanced or metastatic colorectal cancer: Final results of the pegfilgrastim and anti-VEGF evaluation study (PAVES). Clin Colorectal Cancer. 16:103–114. 2017.PubMed/NCBI View Article : Google Scholar

12 

Schwartz LH, Litière S, de Vries E, Ford R, Gwyther S, Mandrekar S, Shankar L, Bogaerts J, Chen A, Dancey J, et al: RECIST 1.1-Update and clarification: From the RECIST committee. Eur J Cancer. 62:132–137. 2016.PubMed/NCBI View Article : Google Scholar

13 

Institute NC: Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. 2010.

14 

Falcone A, Ricci S, Brunetti I, Pfanner E, Allegrini G, Barbara C, Crinò L, Benedetti G, Evangelista W, Fanchini L, et al: Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The gruppo oncologico nord ovest. J Clin Oncol. 25:1670–1676. 2007.PubMed/NCBI View Article : Google Scholar

15 

Hecht JR, Pillai M, Gollard R, Heim W, Swan F, Patel R, Dreiling L, Mo M and Malik I: A randomized, placebo-controlled phase ii study evaluating the reduction of neutropenia and febrile neutropenia in patients with colorectal cancer receiving pegfilgrastim with every-2-week chemotherapy. Clin Colorectal Cancer. 9:95–101. 2010.PubMed/NCBI View Article : Google Scholar

16 

Schutz FA, Jardim DL, Je Y and Choueiri TK: Haematologic toxicities associated with the addition of bevacizumab in cancer patients. Eur J Cancer. 47:1161–1174. 2011.PubMed/NCBI View Article : Google Scholar

17 

Fujii H, Matsuhashi N, Kitahora M, Takahashi T, Hirose C, Iihara H, Yamada Y, Watanabe D, Ishihara T, Suzuki A and Yoshida K: Bevacizumab in combination with TAS-102 improves clinical outcomes in patients with refractory metastatic colorectal cancer: A retrospective study. Oncologist. 25:e469–e476. 2020.PubMed/NCBI View Article : Google Scholar

18 

Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 350:2335–2342. 2004.PubMed/NCBI View Article : Google Scholar

19 

Wildiers H and Reiser M: Relative dose intensity of chemotherapy and its impact on outcomes in patients with early breast cancer or aggressive lymphoma. Crit Rev Oncol Hematol. 77:221–240. 2011.PubMed/NCBI View Article : Google Scholar

20 

Nakayama G, Tanaka C, Uehara K, Mashita N, Hayashi N, Kobayashi D, Kanda M, Yamada S, Fujii T, Sugimoto H, et al: The impact of dose/time modification in irinotecan- and oxaliplatin-based chemotherapies on outcomes in metastatic colorectal cancer. Cancer Chemother Pharmacol. 73:847–855. 2014.PubMed/NCBI View Article : Google Scholar

21 

Aspinall SL, Good CB, Zhao X, Cunningham FE, Heron BB, Geraci M, Passero V, Stone RA, Smith KJ, Rogers R, et al: Adjuvant chemotherapy for stage III colon cancer: Relative dose intensity and survival among veterans. BMC Cancer. 15(62)2015.PubMed/NCBI View Article : Google Scholar

22 

Kirshner JJ, Heckler CE, Janelsins MC, Dakhil SR, Hopkins JO, Coles C and Morrow GR: Prevention of pegfilgrastim-induced bone pain: A phase III double-blind placebo-controlled randomized clinical trial of the university of rochester cancer center clinical community oncology program research base. J Clin Oncol. 30:1974–1979. 2012.PubMed/NCBI View Article : Google Scholar

23 

Kirshner JJ, McDonald MC III, Kruter F, Guinigundo AS, Vanni L, Maxwell CL, Reiner M, Upchurch TE, Garcia J and Morrow PK: NOLAN: A randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim. Support Care Cancer. 26:1323–1334. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tamaki S, Ishikawa H, Suzuki K, Kimura Y, Maemoto R, Abe I, Endo Y, Kakizawa N, Watanabe F, Futsuhara K, Futsuhara K, et al: Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab. Mol Clin Oncol 16: 103, 2022.
APA
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I. ... Rikiyama, T. (2022). Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab. Molecular and Clinical Oncology, 16, 103. https://doi.org/10.3892/mco.2022.2536
MLA
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I., Endo, Y., Kakizawa, N., Watanabe, F., Futsuhara, K., Saito, M., Tsujinaka, S., Miyakura, Y., Rikiyama, T."Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab". Molecular and Clinical Oncology 16.5 (2022): 103.
Chicago
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I., Endo, Y., Kakizawa, N., Watanabe, F., Futsuhara, K., Saito, M., Tsujinaka, S., Miyakura, Y., Rikiyama, T."Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab". Molecular and Clinical Oncology 16, no. 5 (2022): 103. https://doi.org/10.3892/mco.2022.2536
Copy and paste a formatted citation
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Spandidos Publications style
Tamaki S, Ishikawa H, Suzuki K, Kimura Y, Maemoto R, Abe I, Endo Y, Kakizawa N, Watanabe F, Futsuhara K, Futsuhara K, et al: Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab. Mol Clin Oncol 16: 103, 2022.
APA
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I. ... Rikiyama, T. (2022). Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab. Molecular and Clinical Oncology, 16, 103. https://doi.org/10.3892/mco.2022.2536
MLA
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I., Endo, Y., Kakizawa, N., Watanabe, F., Futsuhara, K., Saito, M., Tsujinaka, S., Miyakura, Y., Rikiyama, T."Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab". Molecular and Clinical Oncology 16.5 (2022): 103.
Chicago
Tamaki, S., Ishikawa, H., Suzuki, K., Kimura, Y., Maemoto, R., Abe, I., Endo, Y., Kakizawa, N., Watanabe, F., Futsuhara, K., Saito, M., Tsujinaka, S., Miyakura, Y., Rikiyama, T."Prophylactic use of pegfilgrastim enables the management of severe neutropenia without dose delays in patients with metastatic colorectal cancer treated with TAS‑102 plus bevacizumab". Molecular and Clinical Oncology 16, no. 5 (2022): 103. https://doi.org/10.3892/mco.2022.2536
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