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Article

Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis

  • Authors:
    • Gangling Tong
    • Boran Chen
    • Mingying Zhang
    • Tianyu Wang
    • Xuan Wu
    • Yuye Yan
    • Shubin Wang
    • Shuluan Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Peking University Shenzhen Hospital, Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Cancer Institute of Shenzhen‑PKU‑HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China, Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China
  • Article Number: 106
    |
    Published online on: April 20, 2022
       https://doi.org/10.3892/mco.2022.2539
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Abstract

The effect of hydronephrosis, a common complication of metastatic colorectal cancer (CRC), on the treatment outcome and prognosis of locally advanced or metastatic CRC remains to be elucidated. The present study investigated the clinical characteristics, outcomes, and prognoses of patients with locally advanced or metastatic colorectal cancer (CRC) with hydronephrosis. Clinical data of patients with locally advanced or metastatic CRC who were attending Peking University Shenzhen Hospital and Shenzhen Cancer Hospital between January 2016 and December 2020 were retrospectively collected. A total of 52 patients with hydronephrosis based on CT or MRI findings were selected, and their clinical characteristics, treatment outcomes, and survival times were analyzed. Of the 52 patients, 33 were male (63.5%), and the median age was 49 years (range, 31‑76 years). A total of 15 (28.8%) patients with CRC had synchronous hydronephrosis and the remaining 37 patients had metachronous hydronephrosis. Ureters were either compressed by peritoneal or abdominal cavity metastatic lymph nodes in 34 cases (65.4%) or by direct tumor invasion in 18 cases (34.6%). However, objective response rate (ORR) was higher in the group in which ureters were compressed by peritoneal or abdominal cavity metastatic lymph nodes; ORR, disease control rate and median progression‑free survival (PFS) between the two groups were not statistically different. (P>0.05). The median survival period was only 27.0 months (95% CI, 20.549‑33.451) in patients complicated with malignant hydronephrosis. Univariate and multivariate analyses showed that CA19‑9 might be a prognostic factor for locally advanced and metastatic CRC patients with hydronephrosis. Metachronous metastatic CRC has a high incidence rate of complicated hydronephrosis. Targeted drugs in combination with chemotherapy improve the treatment efficacy and prognosis of patients. Notably, the present study found that CA19‑9 level might be a prognostic factor in CRC patients with hydronephrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Tong G, Chen B, Zhang M, Wang T, Wu X, Yan Y, Wang S and Li S: Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis. Mol Clin Oncol 16: 106, 2022.
APA
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y. ... Li, S. (2022). Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis. Molecular and Clinical Oncology, 16, 106. https://doi.org/10.3892/mco.2022.2539
MLA
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y., Wang, S., Li, S."Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis". Molecular and Clinical Oncology 16.6 (2022): 106.
Chicago
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y., Wang, S., Li, S."Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis". Molecular and Clinical Oncology 16, no. 6 (2022): 106. https://doi.org/10.3892/mco.2022.2539
Copy and paste a formatted citation
x
Spandidos Publications style
Tong G, Chen B, Zhang M, Wang T, Wu X, Yan Y, Wang S and Li S: Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis. Mol Clin Oncol 16: 106, 2022.
APA
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y. ... Li, S. (2022). Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis. Molecular and Clinical Oncology, 16, 106. https://doi.org/10.3892/mco.2022.2539
MLA
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y., Wang, S., Li, S."Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis". Molecular and Clinical Oncology 16.6 (2022): 106.
Chicago
Tong, G., Chen, B., Zhang, M., Wang, T., Wu, X., Yan, Y., Wang, S., Li, S."Treatment efficacy and prognosis analysis in locally advanced or metastatic colorectal cancer patients with hydronephrosis". Molecular and Clinical Oncology 16, no. 6 (2022): 106. https://doi.org/10.3892/mco.2022.2539
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