Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2022 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass

  • Authors:
    • Ali Huwidi
    • Afaf Abobrege
    • Mourad Assidi
    • Abdelbaset Buhmeida
    • Eramah Ermiah
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology, National Cancer Institute, Misurata University, Misurata 051, Libya, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Makkah 21589, Saudi Arabia, Medical Research Unit, National Cancer Institute, Misurata 051, Libya
    Copyright: © Huwidi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 118
    |
    Published online on: May 30, 2022
       https://doi.org/10.3892/mco.2022.2551
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, the Risk Malignancy Index (RMI) was calculated based on menopausal status, ultrasound (US) findings and serum biological cancer antigen 125 (CA‑125) levels as a scoring system in Libyan females with ovarian masses (OMs) to differentiate between benign and malignant tumors. A total of 51 females with OMs referred to the Gynaecology Department of the National Cancer Institute in Misurata (Libya) between January 2019 and December 2020 were retrospectively reviewed for diagnostic testing. Clinicopathological and demographic data were obtained from patient records. A cut‑off point of RMI=200 was used to differentiate between benign and malignant tumors. The mean age of the patients was 47 years (range, 19‑90 years) and 60% of the patients were premenopausal. Examination of the four RMI indices and disease status indicated that the association with the US score (P<0.0001) and with CA‑125 (P=0.017) was highly significant. However, the age at diagnosis and menopausal status did not have any significant association with the disease status. The RMI with a cut‑off point of 200 had a sensitivity and specificity of 87.5 and 90.7%, respectively, and a positive and negative predictive value of 63.6 and 97.5%, respectively. The association between the RMI and disease status was highly significant (P<0.0001). In conclusion, the RMI appears to be a reliable, simple and cost‑effective tool for clinical differentiation between benign and malignant OMs. This may help to improve the optimal diagnosis and planning of an individualized treatment strategy. However, given the small sample size of the cohort, further validation using larger cohorts in other settings is recommended.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Group UCSW: United States cancer statistics: 1999-2010 incidence and mortality web-based report. Atlanta: US Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute 201, 2013.

2 

GBD 2015 Mortality and Causes of Death Collaborators: Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the global burden of disease study 2015. Lancet. 388:1459–1544. 2016.PubMed/NCBI View Article : Google Scholar

3 

Wild CP, Stewart BW and Wild C: World Cancer Report 2014. World Health Organization, Switzerland, 2014.

4 

Coburn SB, Bray F, Sherman ME and Trabert B: International patterns and trends in ovarian cancer incidence, overall and by histologic subtype. Int J Cancer. 140:2451–2460. 2017.PubMed/NCBI View Article : Google Scholar

5 

Rossing MA, Wicklund KG, Cushing-Haugen KL and Weiss NS: Predictive value of symptoms for early detection of ovarian cancer. J Natl Cancer Inst. 102:222–229. 2010.PubMed/NCBI View Article : Google Scholar

6 

Hoffman BL, Schorge JO, Schaffer JI, Halvorson LM, Bradshaw KD and Cunningham FG: Epithelial ovarian cancer. In: Williams Gynecology. 2nd edition. McGraw-Hill, pp853-878, 2012.

7 

Jayson GC, Kohn EC, Kitchener HC and Ledermann JA: Ovarian cancer. Lancet. 384:1376–1388. 2014.PubMed/NCBI View Article : Google Scholar

8 

No authors listed: Surveillance Report (Exceptional Review) 2017-Ovarian Cancer: Recognition and initial management (2011) NICE guideline CG122. National Institute for Health and Care Excellence, London, 2017.

9 

Javdekar R and Maitra N: Risk of malignancy index (RMI) in evaluation of adnexal mass. J Obstet Gynaecol India. 65:117–121. 2015.PubMed/NCBI View Article : Google Scholar

10 

Andersen ES, Knudsen A, Rix P and Johansen B: Risk of malignancy index in the preoperative evaluation of patients with adnexal masses. Gynecol Oncol. 90:109–112. 2003.PubMed/NCBI View Article : Google Scholar

11 

Terzić M, Dotlić J, Ladjević IL, Atanacković J and Ladjević N: Evaluation of the risk malignancy index diagnostic value in patients with adnexal masses. Vojnosanit Pregl. 68:589–593. 2011.PubMed/NCBI View Article : Google Scholar

12 

Moolthiya W and Yuenyao P: The risk of malignancy index (RMI) in diagnosis of ovarian malignancy. Asian Pac J Cancer Prev. 10:865–868. 2009.PubMed/NCBI

13 

Akdeniz N, Kuyumcuoğlu U, Kale A, Erdemoğlu M and Caca F: Risk of malignancy index for adnexal masses. Eur J Gynaecol Oncol. 30:178–180. 2009.PubMed/NCBI

14 

Escudero JM, Auge JM, Filella X, Torne A, Pahisa J and Molina R: Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases. Clin Chem. 57:1534–1544. 2011.PubMed/NCBI View Article : Google Scholar

15 

Myers ER, Bastian LA, Havrilesky LJ, Kulasingam SL, Terplan MS, Cline KE, Gray RN and McCrory DC: Management of adnexal mass. Evid Rep Technol Assess (Full Rep) 1-145, 2006.

16 

Bindal J and Bankey S: Prevalence of ovarian tumours among ovarian mass lesions in Gajra Raja Medical College, Gwalior, India. Int J Reprod Contracept Obstet Gynecol. 6:3907–3911. 2017.

17 

Jha R and Karki S: Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 10:81–85. 2008.PubMed/NCBI

18 

McGuire V, Hartge P, Liao LM, Sinha R, Bernstein L, Canchola AJ, Anderson GL, Stefanick ML and Whittemore AS: Parity and oral contraceptive use in relation to ovarian cancer risk in older women. Cancer Epidemiol Biomarkers Prev. 25:1059–1063. 2016.PubMed/NCBI View Article : Google Scholar

19 

Al-Musalhi K, Al-Kindi M, Ramadhan F, Al-Rawahi T, Al-Hatali K and Mula-Abed WA: Validity of Cancer Antigen-125 (CA-125) and risk of malignancy index (RMI) in the diagnosis of ovarian cancer. Oman Med J. 30:428–434. 2015.PubMed/NCBI View Article : Google Scholar

20 

Liu J, Xu Y and Wang J: Ultrasonography, computed tomography and magnetic resonance imaging for diagnosis of ovarian carcinoma. Eur J Radiol. 62:328–334. 2007.PubMed/NCBI View Article : Google Scholar

21 

Radiology ACo: ACR Appropriateness Criteria 2008: Clinically suspected adnexal mass. American College of Radiology Web site. Available from: http://www.acr.org/SecondaryMainMenuCategories/quality_safety/app_criteria/pdf/ExpertPanelonWomenImaging/SuspectedAdnexalMasses-Doc11. Accessed November 9, 2009.

22 

Valentin L, Ameye L, Jurkovic D, Metzger U, Lécuru F, Van Huffel S and Timmerman D: Which extrauterine pelvic masses are difficult to correctly classify as benign or malignant on the basis of ultrasound findings and is there a way of making a correct diagnosis? Ultrasound Obstet Gynecol. 27:438–444. 2006.PubMed/NCBI View Article : Google Scholar

23 

Patel MD: Practical approach to the adnexal mass. Radiol Clin North Am. 44:879–899. 2006.PubMed/NCBI View Article : Google Scholar

24 

Rein BJ, Gupta S, Dada R, Safi J, Michener C and Agarwal A: Potential markers for detection and monitoring of ovarian cancer. J Oncol. 2011(475983)2011.PubMed/NCBI View Article : Google Scholar

25 

Nazneen T, Begum SA, Mahmud T, Khatoon F, Islam F and Amatullah M: Preoperative analysis of CA-I25 and its relation with histopathological study in ovarian tumours. Mymensingh Med J. 30:402–409. 2021.PubMed/NCBI

26 

Liao XY, Huang GJ, Gao C and Wang GH: A meta-analysis of serum cancer antigen 125 array for diagnosis of ovarian cancer in Chinese. J Cancer Res Ther. (Suppl 10):C222–C224. 2014.PubMed/NCBI View Article : Google Scholar

27 

Van Calster B, Timmerman D, Valentin L, McIndoe A, Ghaem-Maghami S, Testa AC, Vergote I and Bourne T: Triaging women with ovarian masses for surgery: Observational diagnostic study to compare RCOG guidelines with an international ovarian tumour analysis (IOTA) group protocol. BJOG. 119:662–671. 2012.PubMed/NCBI View Article : Google Scholar

28 

Ulusoy S, Akbayir O, Numanoglu C, Ulusoy N, Odabas E and Gulkilik A: The risk of malignancy index in discrimination of adnexal masses. Int J Gynaecol Obstet. 96:186–191. 2007.PubMed/NCBI View Article : Google Scholar

29 

Chia YN, Marsden DE, Robertson G and Hacker NF: Triage of ovarian masses. Aust N Z J Obstet Gynaecol. 48:322–328. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huwidi A, Abobrege A, Assidi M, Buhmeida A and Ermiah E: Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass. Mol Clin Oncol 17: 118, 2022.
APA
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., & Ermiah, E. (2022). Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass. Molecular and Clinical Oncology, 17, 118. https://doi.org/10.3892/mco.2022.2551
MLA
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., Ermiah, E."Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass". Molecular and Clinical Oncology 17.1 (2022): 118.
Chicago
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., Ermiah, E."Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass". Molecular and Clinical Oncology 17, no. 1 (2022): 118. https://doi.org/10.3892/mco.2022.2551
Copy and paste a formatted citation
x
Spandidos Publications style
Huwidi A, Abobrege A, Assidi M, Buhmeida A and Ermiah E: Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass. Mol Clin Oncol 17: 118, 2022.
APA
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., & Ermiah, E. (2022). Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass. Molecular and Clinical Oncology, 17, 118. https://doi.org/10.3892/mco.2022.2551
MLA
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., Ermiah, E."Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass". Molecular and Clinical Oncology 17.1 (2022): 118.
Chicago
Huwidi, A., Abobrege, A., Assidi, M., Buhmeida, A., Ermiah, E."Diagnostic value of risk of malignancy index in the clinical evaluation of ovarian mass". Molecular and Clinical Oncology 17, no. 1 (2022): 118. https://doi.org/10.3892/mco.2022.2551
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team