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Article

Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors

  • Authors:
    • Slawomir Kroczka
    • Kinga Kwiecinska
    • Aleksandra Gergont
    • Anna Grela
    • Olga Gorowska
    • Szymon Skoczen
  • View Affiliations / Copyright

    Affiliations: Department of Child Neurology, Jagiellonian University, Medical College, 30‑663 Krakow, Poland, Department of Pediatric Oncology and Hematology, Jagiellonian University, Medical College, 30‑663 Krakow, Poland, Department of Child Neurology, University Children's Hospital, 30‑663 Krakow, Poland
  • Article Number: 125
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    Published online on: June 14, 2022
       https://doi.org/10.3892/mco.2022.2558
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Abstract

Modern treatment of childhood acute lymphoblastic leukemia (ALL) has resulted in a high cure rate; however, it can cause central nervous system toxicity. In the present study, a group of 136 ALL survivors were screened for changes in P300. Therapy was conducted according to a modified New York (NY) protocol (30 patients) and two subsequent revisions of a modified Berlin‑Frankfurt‑Münster (BFM) protocol (32 and 74 patients). The control group consisted of 58 patients. The survivors had significantly prolonged mean latency of P300 (331.31±28.71 vs. 298.14±38.76 msec, P<0.001) and reaction time (439.51±119.86 vs. 380.11±79.94 msec, P=0.002) compared with in the control group. Abnormalities in the endogenous evoked potentials were observed in 36 patients (26.5%). The mean latency time was significantly longer in the treatment groups compared with in the control group (NY: 329.13±28.07 msec, P=0.001; pBFM: 332.97±23.97 msec, P<0.001; BFM95: 331.47±31.05 msec, P<0.001). The reaction time was equally prolonged in both groups. In comparisons between the studied groups and the control group the most significant prolongation was recorded in the NY group (461.8±140.3 vs. 380.1±78.04 msec, P=0.039). Significantly higher frequency of prolonged reaction time in non‑irradiated patients that received BFM95 was also revealed (21.62 vs. 15.85%, P=0.007). In addition, radiotherapy significantly reduced the P300 wave amplitude (mean values: 10.395±5.727 vs. 12.739±6.508 mV, P=0.027). In conclusion, endogenous P300 event‑related potentials may be a useful tool in screening of subclinical cognitive changes in ALL survivors.
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Copy and paste a formatted citation
Spandidos Publications style
Kroczka S, Kwiecinska K, Gergont A, Grela A, Gorowska O and Skoczen S: Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors. Mol Clin Oncol 17: 125, 2022.
APA
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., & Skoczen, S. (2022). Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors. Molecular and Clinical Oncology, 17, 125. https://doi.org/10.3892/mco.2022.2558
MLA
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., Skoczen, S."Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors". Molecular and Clinical Oncology 17.2 (2022): 125.
Chicago
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., Skoczen, S."Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors". Molecular and Clinical Oncology 17, no. 2 (2022): 125. https://doi.org/10.3892/mco.2022.2558
Copy and paste a formatted citation
x
Spandidos Publications style
Kroczka S, Kwiecinska K, Gergont A, Grela A, Gorowska O and Skoczen S: Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors. Mol Clin Oncol 17: 125, 2022.
APA
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., & Skoczen, S. (2022). Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors. Molecular and Clinical Oncology, 17, 125. https://doi.org/10.3892/mco.2022.2558
MLA
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., Skoczen, S."Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors". Molecular and Clinical Oncology 17.2 (2022): 125.
Chicago
Kroczka, S., Kwiecinska, K., Gergont, A., Grela, A., Gorowska, O., Skoczen, S."Screening of subclinical P300 event‑related potentials changes in childhood acute lymphoblastic leukemia survivors". Molecular and Clinical Oncology 17, no. 2 (2022): 125. https://doi.org/10.3892/mco.2022.2558
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