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Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint

  • Authors:
    • Jesús Eduardo Amezcua-Gálvez
    • Carlos A. Lopez-Garcia
    • Cynthia Villarreal-Garza
    • Victor Lopez‑Rivera
    • Mauricio Canavati‑Marcos
    • Sandra Santuario-Facio
    • Antonio Dono
    • Paloma Del C. Monroig‑Bosque
    • Rocío Ortiz‑López
    • Andrea Leal‑Lopez
    • Gabriela Sofía Gómez‑Macías
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Tecnologico de Monterrey, Hospital San José, Av. Morones Prieto Poniente 3000 Poniente, Los Doctores, Monterrey, NL 64710, México, Breast Cancer Center, Tecnologico de Monterrey, Hospital Zambrano Hellion, Real San Agustín, San Pedro Garza García, NL 66278, México, Department of Neurology, UTHealth McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA, Breast Cancer Center, Tecnologico de Monterrey, Hospital Zambrano Hellion, Real San Agustín, San Pedro Garza García, NL 66278, México, School of Medicine and Health Sciences, Tecnologico de Monterrey, Av Morones Prieto, 3000 Poniente, Los Doctores, Monterrey, Nuevo León, 64710, México, Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, TX 77030, USA, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA, Department of Pathology, Tecnologico de Monterrey, Hospital San José, Av. Morones Prieto Poniente 3000 Poniente, Los Doctores, Monterrey, NL 64710, México
    Copyright: © Amezcua-Gálvez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 132
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    Published online on: July 1, 2022
       https://doi.org/10.3892/mco.2022.2565
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Abstract

Identifying patients with hormone receptor‑positive (HR+) early invasive breast cancer (EIBC) who benefit from adjuvant chemotherapy has improved with molecular signature tests. However, due to high cost and limited availability, alternative tests are used. The present study sought to evaluate the performance of the proliferation marker Ki‑67 to identify these patients and explore its association with molecular signatures and risk stratification markers. From the San José TecSalud Hospital in Monterrey México, patients with HR+ EIBC as tested with EndoPredict or MammaPrint and Ki‑67 index were identified. They were categorized into two groups: Group 1 (June 2016‑August 2018) was evaluated using EndoPredict and Group 2 (June 2016‑August 2018) with MammaPrint. A ≥20% Ki67 index cutoff was utilized to identify highly proliferative EIBC and an area under the receiver‑operating characteristic curve and κ concordance were utilized to evaluate the performance of Ki‑67 index compared to molecular signature tests. In the EndoPredict group, 54/96 patients were considered high‑risk based on their EPclin score, while 57/96 patients had Ki‑67 index ≥20%. However, there was no significant overall concordance between them (59.37%, κ=0.168, P=0.09), while the given risk of distant recurrence given in percentage by EPclin had a positive association with the Ki67 index (P=0.04). In the MammaPrint group, 21/70 patients were considered high‑risk and 36/70 patients presented with a Ki‑67 index ≥20% with a significant overall concordance (67.14%, κ=0.35, P<0.001). In addition, high Ki‑67 index was associated with the Nottingham histological grade in both groups. In conclusion, there was a concordance between Ki‑67 and MammaPrint risk stratification of HR+ EIBC and no concordance with the EndoPredict molecular signature, but a positive association with the given percentage of recurrence and the median Ki‑67 index as the cutoff at our center. Cost‑effectiveness analyses of these tests in developing countries are required; until then, the use of Ki‑67 appears reasonable to aid clinical decisions, together with the other established clinicopathological variables.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000.PubMed/NCBI View Article : Google Scholar

3 

Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001.PubMed/NCBI View Article : Google Scholar

4 

Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B and Senn HJ: Panel members. Personalizing the treatment of women with early breast cancer: Highlights of the St Gallen International expert consensus on the primary therapy of early breast cancer 2013. Ann Oncol. 24:2206–2223. 2013.PubMed/NCBI View Article : Google Scholar

5 

Gluck S, de Snoo F, Peeters J, Stork-Sloots L and Somlo G: Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy. Breast Cancer Res Treat. 139:759–767. 2013.PubMed/NCBI View Article : Google Scholar

6 

Coates AS, Winer EP, Goldhirsch A, Gelber RD, Gnant M, Piccart-Gebhart M, Thürlimann B and Senn HJ: Panel Members. Tailoring therapies-improving the management of early breast cancer: St Gallen International expert consensus on the primary therapy of early breast cancer 2015. Ann Oncol. 26:1533–1546. 2015.PubMed/NCBI View Article : Google Scholar

7 

Tian S, Roepman P, Van't Veer LJ, Bernards R, de Snoo F and Glas AM: Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer. Biomark Insights. 5:129–138. 2010.PubMed/NCBI View Article : Google Scholar

8 

van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 347:1999–2009. 2002.PubMed/NCBI View Article : Google Scholar

9 

Müller BM, Keil E, Lehmann A, Winzer KJ, Richter-Ehrenstein C, Prinzler J, Bangemann N, Reles A, Stadie S, Schoenegg W, et al: The endopredict gene-expression assay in clinical practice-performance and impact on clinical decisions. PLoS One. 8(e68252)2013.PubMed/NCBI View Article : Google Scholar

10 

Filipits M, Rudas M, Jakesz R, Dubsky P, Fitzal F, Singer CF, Dietze O, Greil R, Jelen A, Sevelda P, et al: A new molecular predictor of distant recurrence in ER-positive, HER2-negative breast cancer adds independent information to conventional clinical risk factors. Clin Cancer Res. 17:6012–6020. 2011.PubMed/NCBI View Article : Google Scholar

11 

Duffy MJ, Harbeck N, Nap M, Molina R, Nicolini A, Senkus E and Cardoso F: Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM). Eur J Cancer. 75:284–298. 2017.PubMed/NCBI View Article : Google Scholar

12 

Weigelt B, Reis-Filho JS and Swanton C: Genomic analyses to select patients for adjuvant chemotherapy: Trials and tribulations. Ann Oncol. 23 (Suppl 10):x211–x218. 2012.PubMed/NCBI View Article : Google Scholar

13 

van Steenhoven JEC, Kuijer A, van Diest PJ, van Gorp JM, Straver M, Elias SG, Wesseling J, Rutgers E, Timmer-Bonte JNH, Nieboer P, et al: Conventional pathology versus gene signatures for assessing Luminal A and B type breast cancers: Results of a prospective cohort study. Genes (Basel). 9(261)2018.PubMed/NCBI View Article : Google Scholar

14 

Bustreo S, Osella-Abate S, Cassoni P, Donadio M, Airoldi M, Pedani F, Papotti M, Sapino A and Castellano I: Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: A large case series study with a long-term follow-up. Breast Cancer Res Treat. 157:363–371. 2016.PubMed/NCBI View Article : Google Scholar

15 

Dubsky P, Filipits M, Jakesz R, Rudas M, Singer CF, Greil R, Dietze O, Luisser I, Klug E, Sedivy R, et al: EndoPredict improves the prognostic classification derived from common clinical guidelines in ER-positive, HER2-negative early breast cancer. Ann Oncol. 24:640–647. 2013.PubMed/NCBI View Article : Google Scholar

16 

Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, et al: Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst. 101:736–750. 2009.PubMed/NCBI View Article : Google Scholar

17 

Cuzick J, Dowsett M, Pineda S, Wale C, Salter J, Quinn E, Zabaglo L, Mallon E, Green AR, Ellis IO, et al: Prognostic value of a combined estrogen receptor, progesterone receptor, Ki-67, and human epidermal growth factor receptor 2 immunohistochemical score and comparison with the Genomic Health recurrence score in early breast cancer. J Clin Oncol. 29:4273–4278. 2011.PubMed/NCBI View Article : Google Scholar

18 

de Azambuja E, Cardoso F, de Castro G Jr, Colozza M, Mano MS, Durbecq V, Sotiriou C, Larsimont D, Piccart-Gebhart MJ and Paesmans M: Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients. Br J Cancer. 96:1504–1513. 2007.PubMed/NCBI View Article : Google Scholar

19 

Focke CM, van Diest PJ and Decker T: St Gallen 2015 subtyping of luminal breast cancers: Impact of different Ki67-based proliferation assessment methods. Breast Cancer Res Treat. 159:257–263. 2016.PubMed/NCBI View Article : Google Scholar

20 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B and Senn HJ: Panel members. Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St. Gallen International expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol. 22:1736–1747. 2011.PubMed/NCBI View Article : Google Scholar

21 

Villarreal-Garza C, Lopez-Martinez EA, Deneken-Hernandez Z, Maffuz-Aziz A, Muñoz-Lozano JF, Barragan-Carrillo R, Ramos-Elias P, Moreno B, Diaz-Perez H, Peña-Curiel O, et al: Change in therapeutic management after the EndoPredict assay in a prospective decision impact study of Mexican premenopausal breast cancer patients. PLoS One. 15(e0228884)2020.PubMed/NCBI View Article : Google Scholar

22 

Cardoso F, van't Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, Pierga JY, Brain E, Causeret S, DeLorenzi M, et al: 70-Gene signature as an aid to treatment decisions in early-stage breast cancer. N Engl J Med. 375:717–729. 2016.PubMed/NCBI View Article : Google Scholar

23 

Allison KH, Hammond ME, Dowsett M, McKernin SE, Carey LA, Fitzgibbons PL, Hayes DF, Lakhani SR, Chavez-MacGregor M, Perlmutter J, et al: Estrogen and progesterone receptor testing in breast cancer: ASCO/CAP guideline update. J Clin Oncol. 38:1346–1366. 2020.PubMed/NCBI View Article : Google Scholar

24 

Prat A, Cheang MC, Martín M, Parker JS, Carrasco E, Caballero R, Tyldesley S, Gelmon K, Bernard PS, Nielsen TO and Perou CM: Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer. J Clin Oncol. 31:203–209. 2013.PubMed/NCBI View Article : Google Scholar

25 

Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, et al: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update. J Clin Oncol. 36:2105–2122. 2018.PubMed/NCBI View Article : Google Scholar

26 

Penault-Llorca F and Radosevic-Robin N: Ki67 assessment in breast cancer: An update. Pathology. 49:166–171. 2017.PubMed/NCBI View Article : Google Scholar

27 

Dowsett M, Nielsen TO, A'Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T, et al: Assessment of Ki67 in breast cancer: Recommendations from the International Ki67 in breast cancer working group. J Natl Cancer Inst. 103:1656–1664. 2011.PubMed/NCBI View Article : Google Scholar

28 

Viale G, de Snoo FA, Slaets L, Bogaerts J, van 't Veer L, Rutgers EJ, Piccart-Gebhart MJ, Stork-Sloots L, Glas A, Russo L, et al: Immunohistochemical versus molecular (BluePrint and MammaPrint) subtyping of breast carcinoma. Outcome results from the EORTC 10041/BIG 3-04 MINDACT trial. Breast Cancer Res Treat. 167:123–131. 2018.PubMed/NCBI View Article : Google Scholar

29 

Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 351:2817–2826. 2004.PubMed/NCBI View Article : Google Scholar

30 

Sahebjam S, Aloyz R, Pilavdzic D, Brisson ML, Ferrario C, Bouganim N, Cohen V, Miller WH Jr and Panasci LC: Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score. Br J Cancer. 105:1342–1345. 2011.PubMed/NCBI View Article : Google Scholar

31 

Ahmed W, Malik MFA, Saeed M and Haq F: Copy number profiling of Oncotype DX genes reveals association with survival of breast cancer patients. Mol Biol Rep. 45:2185–2192. 2018.PubMed/NCBI View Article : Google Scholar

32 

Bertucci F, Finetti P, Viens P and Birnbaum D: EndoPredict predicts for the response to neoadjuvant chemotherapy in ER-positive, HER2-negative breast cancer. Cancer Lett. 355:70–75. 2014.PubMed/NCBI View Article : Google Scholar

33 

Maranta AF, Broder S, Fritzsche C, Knauer M, Thürlimann B, Jochum W and Ruhstaller T: Do YOU know the Ki-67 index of your breast cancer patients? Knowledge of your institution's Ki-67 index distribution and its robustness is essential for decision-making in early breast cancer. Breast. 51:120–126. 2020.PubMed/NCBI View Article : Google Scholar

34 

Gluz O, Nitz UA, Christgen M, Kates RE, Shak S, Clemens M, Kraemer S, Aktas B, Kuemmel S, Reimer T, et al: West German study group phase III PlanB trial: First prospective outcome data for the 21-Gene recurrence score assay and concordance of prognostic markers by central and local pathology assessment. J Clin Oncol. 34:2341–2349. 2016.PubMed/NCBI View Article : Google Scholar

35 

Thakur SS, Li H, Chan AMY, Tudor R, Bigras G, Morris D, Enwere EK and Yang H: The use of automated Ki67 analysis to predict Oncotype DX risk-of-recurrence categories in early-stage breast cancer. PLoS One. 13(e0188983)2018.PubMed/NCBI View Article : Google Scholar

36 

Nguyen B, Cusumano PG, Deck K, Kerlin D, Garcia AA, Barone JL, Rivera E, Yao K, de Snoo FA, van den Akker J, et al: Comparison of molecular subtyping with BluePrint, MammaPrint, and TargetPrint to local clinical subtyping in breast cancer patients. Ann Surg Oncol. 19:3257–3263. 2012.PubMed/NCBI View Article : Google Scholar

37 

Bösl A, Spitzmüller A, Jasarevic Z, Rauch S, Jäger S and Offner F: MammaPrint versus EndoPredict: Poor correlation in disease recurrence risk classification of hormone receptor positive breast cancer. PLoS One. 12(e0183458)2017.PubMed/NCBI View Article : Google Scholar

38 

Trihia H, Murray S, Price K, Gelber RD, Golouh R, Goldhirsch A, Coates AS, Collins J, Castiglione-Gertsch M, Gusterson BA, et al: Ki-67 expression in breast carcinoma: Its association with grading systems, clinical parameters, and other prognostic factors-a surrogate marker? Cancer. 97:1321–1331. 2003.PubMed/NCBI View Article : Google Scholar

39 

Marwah N, Batra A, Marwah S, Gupta V, Shakya S and Sen R: Correlation of proliferative index with various clinicopathologic prognostic parameters in primary breast carcinoma: A study from North India. J Cancer Res Ther. 14:537–542. 2018.PubMed/NCBI View Article : Google Scholar

40 

Shokouh TZ, Ezatollah A and Barand P: Interrelationships between Ki67, HER2/neu, p53, ER, and PR status and their associations with tumor grade and lymph node involvement in breast carcinoma subtypes: Retrospective-observational analytical study. Medicine (Baltimore). 94(e1359)2015.PubMed/NCBI View Article : Google Scholar

41 

Pelaez-Garcia A, Yébenes L, Berjón A, Angulo A, Zamora P, Sánchez-Méndez JI, Espinosa E, Redondo A, Heredia-Soto V, Mendiola M, et al: Comparison of risk classification between EndoPredict and MammaPrint in ER-positive/HER2-negative primary invasive breast cancer. PLoS One. 12(e0183452)2017.PubMed/NCBI View Article : Google Scholar

42 

Hannouf MB, Zaric GS, Blanchette P, Brezden-Masley C, Paulden M, McCabe C, Raphael J and Brackstone M: Cost-effectiveness analysis of multigene expression profiling assays to guide adjuvant therapy decisions in women with invasive early-stage breast cancer. Pharmacogenomics J. 20:27–46. 2020.PubMed/NCBI View Article : Google Scholar

43 

Hinde S, Theriou C, May S, Matthews L, Arbon A, Fallowfield L and Bloomfield D: The cost-effectiveness of EndoPredict to inform adjuvant chemotherapy decisions in early breast cancer. Health Policy and Technology. 8:75–83. 2019.

44 

Harnan S, Tappenden P, Cooper K, Stevens J, Bessey A, Rafia R, Ward S, Wong R, Stein RC and Brown J: Tumour profiling tests to guide adjuvant chemotherapy decisions in early breast cancer: A systematic review and economic analysis. Health Technol Assess. 23:1–328. 2019.PubMed/NCBI View Article : Google Scholar

45 

Chen E, Tong KB and Malin JL: Cost-effectiveness of 70-gene MammaPrint signature in node-negative breast cancer. Am J Manag Care. 16:e333–e342. 2010.PubMed/NCBI

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Spandidos Publications style
Amezcua-Gálvez JE, Lopez-Garcia CA, Villarreal-Garza C, Lopez‑Rivera V, Canavati‑Marcos M, Santuario-Facio S, Dono A, Monroig‑Bosque PD, Ortiz‑López R, Leal‑Lopez A, Leal‑Lopez A, et al: Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint. Mol Clin Oncol 17: 132, 2022.
APA
Amezcua-Gálvez, J.E., Lopez-Garcia, C.A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S. ... Gómez‑Macías, G.S. (2022). Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint. Molecular and Clinical Oncology, 17, 132. https://doi.org/10.3892/mco.2022.2565
MLA
Amezcua-Gálvez, J. E., Lopez-Garcia, C. A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S., Dono, A., Monroig‑Bosque, P. D., Ortiz‑López, R., Leal‑Lopez, A., Gómez‑Macías, G. S."Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint". Molecular and Clinical Oncology 17.3 (2022): 132.
Chicago
Amezcua-Gálvez, J. E., Lopez-Garcia, C. A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S., Dono, A., Monroig‑Bosque, P. D., Ortiz‑López, R., Leal‑Lopez, A., Gómez‑Macías, G. S."Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint". Molecular and Clinical Oncology 17, no. 3 (2022): 132. https://doi.org/10.3892/mco.2022.2565
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Spandidos Publications style
Amezcua-Gálvez JE, Lopez-Garcia CA, Villarreal-Garza C, Lopez‑Rivera V, Canavati‑Marcos M, Santuario-Facio S, Dono A, Monroig‑Bosque PD, Ortiz‑López R, Leal‑Lopez A, Leal‑Lopez A, et al: Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint. Mol Clin Oncol 17: 132, 2022.
APA
Amezcua-Gálvez, J.E., Lopez-Garcia, C.A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S. ... Gómez‑Macías, G.S. (2022). Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint. Molecular and Clinical Oncology, 17, 132. https://doi.org/10.3892/mco.2022.2565
MLA
Amezcua-Gálvez, J. E., Lopez-Garcia, C. A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S., Dono, A., Monroig‑Bosque, P. D., Ortiz‑López, R., Leal‑Lopez, A., Gómez‑Macías, G. S."Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint". Molecular and Clinical Oncology 17.3 (2022): 132.
Chicago
Amezcua-Gálvez, J. E., Lopez-Garcia, C. A., Villarreal-Garza, C., Lopez‑Rivera, V., Canavati‑Marcos, M., Santuario-Facio, S., Dono, A., Monroig‑Bosque, P. D., Ortiz‑López, R., Leal‑Lopez, A., Gómez‑Macías, G. S."Concordance between Ki‑67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint". Molecular and Clinical Oncology 17, no. 3 (2022): 132. https://doi.org/10.3892/mco.2022.2565
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