Open Access

Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review

  • Authors:
    • Shunichi Toki
    • Toshihiko Nishisho
    • Ryo Miyagi
    • Yoshimi Bando
    • Mika Sakaki
    • Yusuke Demizu
    • Tomoaki Okimoto
    • Koichi Sairyo
  • View Affiliations

  • Published online on: November 3, 2022     https://doi.org/10.3892/mco.2022.2596
  • Article Number: 163
  • Copyright: © Toki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Soft tissue myoepithelial carcinoma (MEC) is an extremely rare mesenchymal tumor that has a poor prognosis unless complete surgical resection is achieved. The present study reported a case of a 38‑year‑old woman with a tumor in the left paraspinal region at L2 to L3 with vertebral destruction. MEC was diagnosed based on molecular pathological examination of a biopsy specimen. Because curative surgery was expected to be difficult, a combination of chemotherapy with doxorubicin and ifosfamide and proton beam therapy as local therapy was performed, resulting in long‑term survival for at least 7.8 years. To the best of our knowledge, this is the first case of soft tissue MEC for which classical cytotoxic chemotherapy and proton beam therapy were effective. Although surgical resection with negative margins is the mainstay of treatment for MEC, adequate doxorubicin‑based systemic therapy and high‑dose radiation therapy may be a feasible alternative in patients with unresectable or advanced MEC. Future studies on the relationship between molecular pathological features, including biomarkers, and the selection of therapeutic agents are warranted.

Related Articles

Journal Cover

December-2022
Volume 17 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Toki S, Nishisho T, Miyagi R, Bando Y, Sakaki M, Demizu Y, Okimoto T and Sairyo K: Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Mol Clin Oncol 17: 163, 2022
APA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y. ... Sairyo, K. (2022). Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Molecular and Clinical Oncology, 17, 163. https://doi.org/10.3892/mco.2022.2596
MLA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17.6 (2022): 163.
Chicago
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17, no. 6 (2022): 163. https://doi.org/10.3892/mco.2022.2596