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Molecular and Clinical Oncology
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Case Report Open Access

Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review

  • Authors:
    • Shunichi Toki
    • Toshihiko Nishisho
    • Ryo Miyagi
    • Yoshimi Bando
    • Mika Sakaki
    • Yusuke Demizu
    • Tomoaki Okimoto
    • Koichi Sairyo
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770‑8503, Japan, Division of Pathology, Tokushima University Hospital, Tokushima 770‑8503, Japan, Department of Radiation Oncology, Hyogo Ion Beam Medical Center Kobe Proton Center, Kobe, Hyogo 650‑0047, Japan, Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo 679‑5165, Japan
    Copyright: © Toki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
    |
    Published online on: November 3, 2022
       https://doi.org/10.3892/mco.2022.2596
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Abstract

Soft tissue myoepithelial carcinoma (MEC) is an extremely rare mesenchymal tumor that has a poor prognosis unless complete surgical resection is achieved. The present study reported a case of a 38‑year‑old woman with a tumor in the left paraspinal region at L2 to L3 with vertebral destruction. MEC was diagnosed based on molecular pathological examination of a biopsy specimen. Because curative surgery was expected to be difficult, a combination of chemotherapy with doxorubicin and ifosfamide and proton beam therapy as local therapy was performed, resulting in long‑term survival for at least 7.8 years. To the best of our knowledge, this is the first case of soft tissue MEC for which classical cytotoxic chemotherapy and proton beam therapy were effective. Although surgical resection with negative margins is the mainstay of treatment for MEC, adequate doxorubicin‑based systemic therapy and high‑dose radiation therapy may be a feasible alternative in patients with unresectable or advanced MEC. Future studies on the relationship between molecular pathological features, including biomarkers, and the selection of therapeutic agents are warranted.
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Copy and paste a formatted citation
Spandidos Publications style
Toki S, Nishisho T, Miyagi R, Bando Y, Sakaki M, Demizu Y, Okimoto T and Sairyo K: Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Mol Clin Oncol 17: 163, 2022.
APA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y. ... Sairyo, K. (2022). Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Molecular and Clinical Oncology, 17, 163. https://doi.org/10.3892/mco.2022.2596
MLA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17.6 (2022): 163.
Chicago
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17, no. 6 (2022): 163. https://doi.org/10.3892/mco.2022.2596
Copy and paste a formatted citation
x
Spandidos Publications style
Toki S, Nishisho T, Miyagi R, Bando Y, Sakaki M, Demizu Y, Okimoto T and Sairyo K: Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Mol Clin Oncol 17: 163, 2022.
APA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y. ... Sairyo, K. (2022). Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review. Molecular and Clinical Oncology, 17, 163. https://doi.org/10.3892/mco.2022.2596
MLA
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17.6 (2022): 163.
Chicago
Toki, S., Nishisho, T., Miyagi, R., Bando, Y., Sakaki, M., Demizu, Y., Okimoto, T., Sairyo, K."Combination chemotherapy of doxorubicin and ifosfamide with proton beam therapy for myoepithelial carcinoma originating in the paraspinal region: A case report and literature review". Molecular and Clinical Oncology 17, no. 6 (2022): 163. https://doi.org/10.3892/mco.2022.2596
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