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Case Report Open Access

Gastric adenocarcinoma with high‑level microsatellite instability: A case report

  • Authors:
    • Alejandro Alfaro
    • Daniel Zanabria
    • Alfredo Aguilar
    • Sergio A. Jimenez‑Solano
    • Alejandra Zevallos
    • Williams Fajardo
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Hospital Nacional Dos de Mayo, Lima 15003, Peru, Department of Pathology, Oncosalud‑AUNA, Lima 15036, Peru, Basic and Translational Research Unit, Oncosalud‑AUNA, Lima 15036, Peru, Faculty of Natural Sciences and Mathematics, Universidad Nacional Federico Villarreal, Lima 15007, Peru, School of Medicine, Universidad Privada San Juan Bautista, Lima 15067, Peru
    Copyright: © Alfaro et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 16
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    Published online on: January 26, 2023
       https://doi.org/10.3892/mco.2023.2612
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Abstract

Gastric cancer (GC) ranks fifth on the list of the most common malignancies worldwide. In Peru, gastric neoplasms are considered the second leading cause of mortality among males. Among the molecular subgroups of GC, microsatellite instability presents a favorable prognosis due to its hypermutated phenotype, which activates immunosurveillance. The present study describes the case of a 75‑year‑old patient, who was admitted in the hospital with a history of upper gastrointestinal bleeding and recurrent hospital admission, due to severe anemia. The patient presented with pale skin, normal vital functions, slight swelling of the lower extremities, and abdominal distention and bloating upon a physical examination. An endoscopic examination revealed an infiltrating circular ulcerated lesion. The histopathological analysis identified a moderately differentiated intestinal‑type adenocarcinoma with pathological stage T3N0M0. Tumor genomic profiling demonstrated alterations in 15 different genes with a tumor mutational burden of 28 mutations/Mb. Finally, the patient underwent a partial gastrectomy without pre‑operative chemotherapy. After 4 days, the patient presented with post‑operative complications for which he was re‑operated on. The patient did not survive. To the best of our knowledge, in the present case, pernicious anemia was an early sign of GC and a gastroscopy had to be performed. Furthermore, MutS homolog 3 alterations probably conditioned the presence of multiple frame‑shift mutations.
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Copy and paste a formatted citation
Spandidos Publications style
Alfaro A, Zanabria D, Aguilar A, Jimenez‑Solano SA, Zevallos A and Fajardo W: Gastric adenocarcinoma with high‑level microsatellite instability: A case report. Mol Clin Oncol 18: 16, 2023.
APA
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S.A., Zevallos, A., & Fajardo, W. (2023). Gastric adenocarcinoma with high‑level microsatellite instability: A case report. Molecular and Clinical Oncology, 18, 16. https://doi.org/10.3892/mco.2023.2612
MLA
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S. A., Zevallos, A., Fajardo, W."Gastric adenocarcinoma with high‑level microsatellite instability: A case report". Molecular and Clinical Oncology 18.3 (2023): 16.
Chicago
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S. A., Zevallos, A., Fajardo, W."Gastric adenocarcinoma with high‑level microsatellite instability: A case report". Molecular and Clinical Oncology 18, no. 3 (2023): 16. https://doi.org/10.3892/mco.2023.2612
Copy and paste a formatted citation
x
Spandidos Publications style
Alfaro A, Zanabria D, Aguilar A, Jimenez‑Solano SA, Zevallos A and Fajardo W: Gastric adenocarcinoma with high‑level microsatellite instability: A case report. Mol Clin Oncol 18: 16, 2023.
APA
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S.A., Zevallos, A., & Fajardo, W. (2023). Gastric adenocarcinoma with high‑level microsatellite instability: A case report. Molecular and Clinical Oncology, 18, 16. https://doi.org/10.3892/mco.2023.2612
MLA
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S. A., Zevallos, A., Fajardo, W."Gastric adenocarcinoma with high‑level microsatellite instability: A case report". Molecular and Clinical Oncology 18.3 (2023): 16.
Chicago
Alfaro, A., Zanabria, D., Aguilar, A., Jimenez‑Solano, S. A., Zevallos, A., Fajardo, W."Gastric adenocarcinoma with high‑level microsatellite instability: A case report". Molecular and Clinical Oncology 18, no. 3 (2023): 16. https://doi.org/10.3892/mco.2023.2612
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