Angiomatous meningioma with bizarre nuclei: A case report
- Authors:
- Yanling Shen
- Xueqing Liu
- Wensheng Yang
View Affiliations
Affiliations: Department of Pathology, Army 73rd Group Military Hospital of PLA and Xiamen University Affiliated Chenggong Hospital, Xiamen, Fujian 361000, P.R. China
- Published online on: May 3, 2023 https://doi.org/10.3892/mco.2023.2642
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Article Number:
46
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Copyright: © Shen
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
Angiomatous meningioma (AM) is a relatively rare subtype of WHO grade I meningioma. A relatively rare case of AM was recently encountered in a 45‑year‑old woman. The present case not only observed the typical AM histological pattern but also a large number of cells with bizarre, large, deeply staining and unevenly distributed nuclei. These cells with bizarre nuclei showed a similar pattern of immunoreactivity as meningeal epithelial cells. Although the presence of a large number of cells with bizarre nuclei in this case increased tumour cell atypia, the cells did not differ with regard to proliferative activity and mitotic imaging. Therefore, the patient was ultimately diagnosed as having AM with bizarre nuclei, WHO grade I. This manifestation of nuclear atypia and pleomorphism may be due to ‘degenerative changes’ in pre‑existing, long‑established vascular lesions, similar to those seen in degenerative schwannomas and symplastic haemangioma, rather than being considered an indicator of malignancy.
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