Open Access

Evaluation of the significance of subcarinal lymph node dissection in stage IB non‑small cell lung cancer

  • Authors:
    • Feng Wang
    • Xiangyang Yu
    • Yi Han
    • Lanjun Zhang
    • Shuku Liu
  • View Affiliations

  • Published online on: May 16, 2023     https://doi.org/10.3892/mco.2023.2646
  • Article Number: 50
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lymph node dissection is used to treat early‑stage lung cancer. The present study aimed to investigate if resecting the subcarinal lymph nodes affects prognosis of patients with stage IB non‑small cell lung cancer (NSCLC). A total of 597 patients with stage IB NSCLC who underwent lung cancer surgery at Sun Yat‑Sen University Cancer Center from January 1999 to December 2009 were included in the present study. The potential prognostic factors were evaluated using the Cox proportional hazard regression model. A total of 252 cases were obtained following propensity score matching (PSM). To compare overall survival (OS) and recurrence‑free survival (RFS), Kaplan‑Meier method and log‑rank test were used. Among the 597 cases included, 185 did not undergo subcarinal lymph node resection, whereas 412 did. There were statistically significant differences between the two groups in terms of bronchial invasion, number of resected lymph node stations and resected lymph node numbers (P<0.05). Age, family history of cancer and the number of resected lymph nodes were prognostic factors for OS, whereas age and the number of resected lymph nodes were prognostic factors for RFS (P<0.05). Resection of subcarinal lymph nodes was not associated with OS and RFS. After PSM, survival analysis was recalculated using the Kaplan‑Meier method and log‑rank test; subcarinal lymph node resection was not statistically associated with OS and RFS. (P>0.05). For stage IB NSCLC, there was no statistically significant association between subcarinal lymph node resection and OS and RFS. Subcarinal lymph node resection in surgery of stage IB NSCLC may be considered optional.
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June-2023
Volume 18 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Wang F, Yu X, Han Y, Zhang L and Liu S: Evaluation of the significance of subcarinal lymph node dissection in stage IB non‑small cell lung cancer. Mol Clin Oncol 18: 50, 2023.
APA
Wang, F., Yu, X., Han, Y., Zhang, L., & Liu, S. (2023). Evaluation of the significance of subcarinal lymph node dissection in stage IB non‑small cell lung cancer. Molecular and Clinical Oncology, 18, 50. https://doi.org/10.3892/mco.2023.2646
MLA
Wang, F., Yu, X., Han, Y., Zhang, L., Liu, S."Evaluation of the significance of subcarinal lymph node dissection in stage IB non‑small cell lung cancer". Molecular and Clinical Oncology 18.6 (2023): 50.
Chicago
Wang, F., Yu, X., Han, Y., Zhang, L., Liu, S."Evaluation of the significance of subcarinal lymph node dissection in stage IB non‑small cell lung cancer". Molecular and Clinical Oncology 18, no. 6 (2023): 50. https://doi.org/10.3892/mco.2023.2646