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Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience

  • Authors:
    • Ewelina Biskup
    • Céline Montavon Sartorius
    • Andreas Müller
    • Cornelia Leo
    • Catrina Uhlmann Nussbaum
    • Elena Laura Georgescu Margarint
    • Daniel Koychev
    • Alexander Schreiber
    • Christian Taverna
    • David Thorn
    • Marcus Vetter
  • View Affiliations / Copyright

    Affiliations: Department of Basic and Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R. China, Department of Medical Oncology and Breast Cancer Center, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland, Canton Hospital Winterthur (Med. Oncology), 8400 Winterthur, Switzerland, Department of Gynecology, Canton Hospital Baden, 5404 Baden, Switzerland, Department of Internal Medicine, Canton Hospital Olten, 4600 Olten, Switzerland, Shanghai East International Medical Center, Shanghai 200120, P.R. China, Tumor Center ZeTuP, 8640 Rapperswil, Switzerland, Canton Hospital Aarau, 5001 Aarau, Switzerland, Canton Hospital Muensterlingen, 8596 Münsterlingen, Switzerland, Oncology Private Practice Basel, Department of Medical Oncology, University Hospital Basel, 4052 Basel, Switzerland, Medical University Clinic, Canton Hospital Baselland, University of Basel, 4410 Liestal, Switzerland
    Copyright: © Biskup et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: May 18, 2023
       https://doi.org/10.3892/mco.2023.2648
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Abstract

Trastuzumab and pertuzumab with taxane‑based chemotherapy are considered the first‑line standard therapy for human epidermal growth factor receptor 2 (HER2)‑positive metastatic breast cancer (mBC). Pertuzumab is also a later‑line therapy for mBC in Switzerland, although limited safety and efficacy data are available. The present study assessed the therapeutic regimens, toxicities and clinical outcomes after second‑ or later‑line pertuzumab therapy in patients with mBC who did not receive pertuzumab as a first‑line therapy. Physicians from nine major Swiss oncology centers retrospectively completed a questionnaire for each pertuzumab‑naive patient who was treated with pertuzumab as a second‑ or later‑line therapy. Of 35 patients with HER2‑positive mBC (median age, 49 years; range, 35‑87 years), 14 received pertuzumab as a second‑line therapy, 6 as a third‑line therapy, and 15 as a fourth‑ or later‑line therapy. A total of 20 patients (57%) died during the study period. The median overall survival was 74.2 months (95% confidence interval, 47.6‑139.8 months). Grade (G) 3/4 adverse events (AEs) were reported in 14% of patients, with only 1 patient discontinuing therapy due to pertuzumab‑related toxicities. The most common AE was fatigue (overall, 46%; G3, 11%). Overall, congestive heart disease occurred in 14% of patients (G3, 6%), nausea in 14% of patients (all G1), and myelosuppression in 12% of patients (G3, 6%). In conclusion, the median overall survival of patients who underwent second‑ or later‑line pertuzumab treatment was similar to that reported for patients who underwent first‑line pertuzumab treatment, and the safety profile was acceptable. These data support the use of pertuzumab for second‑ or later‑line therapy when it was not administered as first‑line therapy.
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1 

World Health Organization, Breast cancer, 2020. https://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/.

2 

Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A and McGuire WL: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 235:177–182. 1987.PubMed/NCBI View Article : Google Scholar

3 

Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B and Senn HJ: Panel members. Personalizing the treatment of women with early breast cancer: Highlights of the St Gallen international expert consensus on the primary therapy of early breast cancer 2013. Ann Oncol. 24:2206–2223. 2013.PubMed/NCBI View Article : Google Scholar

4 

Andrulis IL, Bull SB, Blackstein ME, Sutherland D, Mak C, Sidlofsky S, Pritzker KP, Hartwick RW, Hanna W, Lickley L, et al: neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto breast cancer study group. J Clin Oncol. 16:1340–1349. 1998.PubMed/NCBI View Article : Google Scholar

5 

Adams CW, Allison DE, Flagella K, Presta L, Clarke J, Dybdal N, McKeever K and Sliwkowski MX: Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother. 55:717–727. 2006.PubMed/NCBI View Article : Google Scholar

6 

Hudis CA: Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med. 357:39–51. 2007.PubMed/NCBI View Article : Google Scholar

7 

Scheuer W, Friess T, Burtscher H, Bossenmaier B, Endl J and Hasmann M: Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res. 69:9330–9336. 2009.PubMed/NCBI View Article : Google Scholar

8 

Baselga J, Cortés J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, et al: Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 366:109–119. 2012.PubMed/NCBI View Article : Google Scholar

9 

Swain SM, Baselga J, Kim SB, Ro J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Heeson S, et al: Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med. 372:724–734. 2015.PubMed/NCBI View Article : Google Scholar

10 

Bachelot T, Ciruelos E, Schneeweiss A, Puglisi F, Peretz-Yablonski T, Bondarenko I, Paluch-Shimon S, Wardley A, Merot JL, du Toit Y, et al: Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE). Ann Oncol. 30:766–773. 2019.PubMed/NCBI View Article : Google Scholar

11 

Perez EA, López-Vega JM, Petit T, Zamagni C, Easton V, Kamber J, Restuccia E and Andersson M: Safety and efficacy of vinorelbine in combination with pertuzumab and trastuzumab for first-line treatment of patients with HER2-positive locally advanced or metastatic breast cancer: VELVET Cohort 1 final results. Breast Cancer Res. 18(126)2016.PubMed/NCBI View Article : Google Scholar

12 

Andersson M, López-Vega JM, Petit T, Zamagni C, Easton V, Kamber J, Restuccia E and Perez EA: Efficacy and safety of pertuzumab and trastuzumab administered in a single infusion bag, followed by vinorelbine: VELVET Cohort 2 final results. Oncologist. 22:1160–1168. 2017.PubMed/NCBI View Article : Google Scholar

13 

Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A and Kaufman B: Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 355:2733–2743. 2006.PubMed/NCBI View Article : Google Scholar

14 

National Comprehensive Cancer Network, NCCN Clinical Practice Guidelines in Oncology: Breast Cancer, 2021. https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf.

15 

Rimawi MF and Osborne CK: Revisiting the use of HER2-targeted therapies in the adjuvant treatment of early breast cancer. J Clin Oncol. 33:1236–1238. 2015.

16 

Biserni GB, Engstrøm MJ and Bofin AM: HER2 gene copy number and breast cancer-specific survival. Histopathology. 69:871–879. 2016.PubMed/NCBI View Article : Google Scholar

17 

Gradishar WJ, Anderson BO, Abraham J, Aft R, Agnese D, Allison KH, Blair SL, Burstein HJ, Dang C, Elias AD, et al: Breast cancer, version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 18:452–478. 2020.PubMed/NCBI View Article : Google Scholar

18 

Sledge GW Jr, Toi M, Neven P, Sohn J, Inoue K, Pivot X, Burdaeva O, Okera M, Masuda N, Kaufman PA, et al: MONARCH 2: Abemaciclib in combination with fulvestrant in women with HR+/HER2-advanced breast cancer who had progressed while receiving endocrine therapy. J Clin Oncol. 35:2875–2884. 2017.PubMed/NCBI View Article : Google Scholar

19 

Modi S, Saura C, Yamashita T, Park YH, Kim SB, Tamura K, Andre F, Iwata H, Ito Y, Tsurutani J, et al: Trastuzumab deruxtecan in previously treated HER2-positive breast cancer. N Engl J Med. 382:610–621. 2020.PubMed/NCBI View Article : Google Scholar

20 

Barok M, Tanner M, Köninki K and Isola J: Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo. Breast Cancer Res. 13(R46)2011.PubMed/NCBI View Article : Google Scholar

21 

Murthy RK, Loi S, Okines A, Paplomata E, Hamilton E, Hurvitz SA, Lin NU, Borges V, Abramson V, Anders C, et al: Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer. N Engl J Med. 382:597–609. 2020.PubMed/NCBI View Article : Google Scholar

22 

Waddell T, Kotsori A, Constantinidou A, Yousaf N, Ashley S, Parton M, Allen M, Starling N, Papadopoulos P, O'Brien M, et al: Trastuzumab beyond progression in HER2-positive advanced breast cancer: The Royal Marsden experience. Br J Cancer. 104:1675–1679. 2011.PubMed/NCBI View Article : Google Scholar

23 

Baselga J, Gelmon KA, Verma S, Wardley A, Conte P, Miles D, Bianchi G, Cortes J, McNally VA, Ross GA, et al: Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 28:1138–1144. 2010.PubMed/NCBI View Article : Google Scholar

24 

Urruticoechea A, Rizwanullah M, Im SA, Ruiz ACS, Láng I, Tomasello G, Douthwaite H, Badovinac Crnjevic T, Heeson S, Eng-Wong J and Muñoz M: Randomized phase III trial of trastuzumab plus capecitabine with or without pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who experienced disease progression during or after trastuzumab-based therapy. J Clin Oncol. 35:3030–3038. 2017.PubMed/NCBI View Article : Google Scholar

25 

Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, et al: Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 13:25–32. 2012.PubMed/NCBI View Article : Google Scholar

26 

Amiri-Kordestani L, Wedam S, Zhang L, Tang S, Tilley A, Ibrahim A, Justice R, Pazdur R and Cortazar P: First FDA approval of neoadjuvant therapy for breast cancer: Pertuzumab for the treatment of patients with HER2-positive breast cancer. Clin Cancer Res. 20:5359–5364. 2014.PubMed/NCBI View Article : Google Scholar

27 

ClinicalTrials.gov: Phase III trial of pertuzumab and trastuzumab plus endocrine therapy versus chemotherapy plus trastuzumab and pertuzumab in patients with hormone receptor-positive, HER2-positive primary breast cancer (Detect V/CHEVENDO), 2015. https://clinicaltrials.gov/ct2/show/NCT02344472.

28 

Kute T, Lackey KA and Sutton LM: Targeted therapy in HER2-positive metastatic breast cancer: A review of the literature. J Adv Pract Oncol. 9:401–414. 2018.

29 

Huober J, Fasching PA, Barsoum M, Petruzelka L, Wallwiener M, Thomssen C and Untch M: Higher efficacy of the combination of trastuzumab and pertuzumab in the neoadjuvant setting compared with the adjuvant setting in patients with HER2-positive breast cancer. J Clin Oncol. 33:983–990. 2015.

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Copy and paste a formatted citation
Spandidos Publications style
Biskup E, Sartorius CM, Müller A, Leo C, Nussbaum CU, Georgescu Margarint E, Koychev D, Schreiber A, Taverna C, Thorn D, Thorn D, et al: Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience. Mol Clin Oncol 19: 52, 2023.
APA
Biskup, E., Sartorius, C.M., Müller, A., Leo, C., Nussbaum, C.U., Georgescu Margarint, E. ... Vetter, M. (2023). Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience. Molecular and Clinical Oncology, 19, 52. https://doi.org/10.3892/mco.2023.2648
MLA
Biskup, E., Sartorius, C. M., Müller, A., Leo, C., Nussbaum, C. U., Georgescu Margarint, E., Koychev, D., Schreiber, A., Taverna, C., Thorn, D., Vetter, M."Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience". Molecular and Clinical Oncology 19.1 (2023): 52.
Chicago
Biskup, E., Sartorius, C. M., Müller, A., Leo, C., Nussbaum, C. U., Georgescu Margarint, E., Koychev, D., Schreiber, A., Taverna, C., Thorn, D., Vetter, M."Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience". Molecular and Clinical Oncology 19, no. 1 (2023): 52. https://doi.org/10.3892/mco.2023.2648
Copy and paste a formatted citation
x
Spandidos Publications style
Biskup E, Sartorius CM, Müller A, Leo C, Nussbaum CU, Georgescu Margarint E, Koychev D, Schreiber A, Taverna C, Thorn D, Thorn D, et al: Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience. Mol Clin Oncol 19: 52, 2023.
APA
Biskup, E., Sartorius, C.M., Müller, A., Leo, C., Nussbaum, C.U., Georgescu Margarint, E. ... Vetter, M. (2023). Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience. Molecular and Clinical Oncology, 19, 52. https://doi.org/10.3892/mco.2023.2648
MLA
Biskup, E., Sartorius, C. M., Müller, A., Leo, C., Nussbaum, C. U., Georgescu Margarint, E., Koychev, D., Schreiber, A., Taverna, C., Thorn, D., Vetter, M."Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience". Molecular and Clinical Oncology 19.1 (2023): 52.
Chicago
Biskup, E., Sartorius, C. M., Müller, A., Leo, C., Nussbaum, C. U., Georgescu Margarint, E., Koychev, D., Schreiber, A., Taverna, C., Thorn, D., Vetter, M."Pertuzumab as second‑ or later‑line therapy for human epidermal growth factor receptor 2‑positive metastatic breast cancer: A clinical experience". Molecular and Clinical Oncology 19, no. 1 (2023): 52. https://doi.org/10.3892/mco.2023.2648
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