Open Access

Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review

  • Authors:
    • Jie Tang
    • Xiu-Wen Li
    • Yong Wu
    • Zhen Su
    • Yan He
    • Xue-Wen Sun
    • Xiao-Long Cao
    • Yi-Hua Li
    • Bi-Cheng Wang
    • Guo-Rong Zou
  • View Affiliations

  • Published online on: June 13, 2023     https://doi.org/10.3892/mco.2023.2653
  • Article Number: 57
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Radiation‑related nasopharyngeal necrosis (RRNN) is a rare and often fatal complication in patients with nasopharyngeal carcinoma (NPC). Currently, no standard treatments are recommended for RRNN. The effects of traditional conservative treatments are suboptimal, and surgery for RRNN cannot be performed by inexperienced doctors. In the present study, the use of Endostar in two patients with RRNN was evaluated. Two patients with RRNN were treated at the Department of Oncology, Panyu Central Hospital (Guangzhou, China). Endostar was administrated (15 mg/day from day 1 to day 7, every three weeks) intravenously for four and seven cycles in a male and a female patient, respectively. The effects of Endostar were assessed using magnetic resonance imaging (MRI) and a nasopharyngoscope. The symptoms of RRNN in both patients were relieved after treatment with Endostar. MRI and nasopharyngoscope analysis revealed that necrosis of the nasopharynx was substantially decreased and nasopharyngeal ulcers were healed. Endostar has the potential to be a novel, effective therapy for the treatment of patients with RRNN. However, clinical trials are required to confirm the results of the present study.
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July-2023
Volume 19 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Tang J, Li X, Wu Y, Su Z, He Y, Sun X, Cao X, Li Y, Wang B, Zou G, Zou G, et al: Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review. Mol Clin Oncol 19: 57, 2023
APA
Tang, J., Li, X., Wu, Y., Su, Z., He, Y., Sun, X. ... Zou, G. (2023). Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review. Molecular and Clinical Oncology, 19, 57. https://doi.org/10.3892/mco.2023.2653
MLA
Tang, J., Li, X., Wu, Y., Su, Z., He, Y., Sun, X., Cao, X., Li, Y., Wang, B., Zou, G."Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review". Molecular and Clinical Oncology 19.1 (2023): 57.
Chicago
Tang, J., Li, X., Wu, Y., Su, Z., He, Y., Sun, X., Cao, X., Li, Y., Wang, B., Zou, G."Treating radiation‑related nasopharyngeal necrosis with endostar in patient with nasopharyngeal carcinoma: A report of two cases and a literature review". Molecular and Clinical Oncology 19, no. 1 (2023): 57. https://doi.org/10.3892/mco.2023.2653