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Review Open Access

An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review)

  • Authors:
    • Eleftheria Karaviti
    • Athanasios Kontogiannis
    • Aristotelis Anastopoulos
    • Elias Kotteas
    • Georgia Gomatou
  • View Affiliations / Copyright

    Affiliations: Oncology Unit, Third Department of Medicine, ‘Sotiria’ General Hospital of Diseases of The Chest, National and Kapodistrian University of Athens, Athens 11527, Greece, Oncology Unit, Third Department of Medicine, ‘Sotiria’ General Hospital of Diseases of The Chest, National and Kapodistrian University of Athens, Athens 11527, Greece
    Copyright: © Karaviti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
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    Published online on: June 22, 2023
       https://doi.org/10.3892/mco.2023.2657
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Abstract

Telomeres are tandem repeats of DNA sequences protecting the end of linear chromosomes. Replicative senescence due to telomere attrition is considered a tumor‑preventing mechanism in differentiated somatic cells. However, telomere shortening is associated with genome instability and several disease entities. During carcinogenesis, the development of a telomere maintenance mechanism, predominately through the activation of the telomerase enzyme, represents a hallmark of cancer, since it enables cancer cells to avert senescence and divide indefinitely. Although research of the involvement of telomeres and telomerase in various malignant neoplasms has gained a large amount of interest, the timing and relevance of their role in pre‑neoplastic lesions remain to be determined. The present narrative review aims to summarize the evidence regarding the role of telomeres and telomerase in pre‑neoplasia across different types of tissues.
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Copy and paste a formatted citation
Spandidos Publications style
Karaviti E, Kontogiannis A, Anastopoulos A, Kotteas E and Gomatou G: An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review). Mol Clin Oncol 19: 61, 2023.
APA
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., & Gomatou, G. (2023). An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review). Molecular and Clinical Oncology, 19, 61. https://doi.org/10.3892/mco.2023.2657
MLA
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., Gomatou, G."An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review)". Molecular and Clinical Oncology 19.2 (2023): 61.
Chicago
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., Gomatou, G."An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review)". Molecular and Clinical Oncology 19, no. 2 (2023): 61. https://doi.org/10.3892/mco.2023.2657
Copy and paste a formatted citation
x
Spandidos Publications style
Karaviti E, Kontogiannis A, Anastopoulos A, Kotteas E and Gomatou G: An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review). Mol Clin Oncol 19: 61, 2023.
APA
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., & Gomatou, G. (2023). An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review). Molecular and Clinical Oncology, 19, 61. https://doi.org/10.3892/mco.2023.2657
MLA
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., Gomatou, G."An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review)". Molecular and Clinical Oncology 19.2 (2023): 61.
Chicago
Karaviti, E., Kontogiannis, A., Anastopoulos, A., Kotteas, E., Gomatou, G."An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review)". Molecular and Clinical Oncology 19, no. 2 (2023): 61. https://doi.org/10.3892/mco.2023.2657
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