Open Access

Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report

  • Authors:
    • Bernhard Strasser
    • Monika Grünberger
    • Rita Steindl
    • Sonja Heibl
    • Josef Thaler
    • Alexander Haushofer
  • View Affiliations

  • Published online on: June 28, 2023     https://doi.org/10.3892/mco.2023.2658
  • Article Number: 62
  • Copyright: © Strasser et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myelodysplastic/myeloproliferative neoplasm with neutrophilia (MDS/MPN‑N; previously referred to as atypical chronic myeloid leukemia) is a type of myelodysplastic syndrome/myeloproliferative neoplasm. A molecular genetic precondition for diagnosis is BCR::ABL negativity; further diagnostic criteria include clinicopathological assessments, such as peripheral blood leukocyte counts, the number of neutrophils and their precursors, and the presence of dysgranulopoiesis. The present case report highlights the importance of differential diagnoses with a stringent diagnostic workup according to the 5th Edition of the World Health Organization Classification of Hematolymphoid Tumors. A systematic review of the literature from 2013 to 2022 covering the mutational landscape of MDS/MPN‑N was also performed to highlight recent improvements in the molecular genetic diagnostics of this disease.
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August-2023
Volume 19 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Strasser B, Grünberger M, Steindl R, Heibl S, Thaler J and Haushofer A: Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report. Mol Clin Oncol 19: 62, 2023
APA
Strasser, B., Grünberger, M., Steindl, R., Heibl, S., Thaler, J., & Haushofer, A. (2023). Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report. Molecular and Clinical Oncology, 19, 62. https://doi.org/10.3892/mco.2023.2658
MLA
Strasser, B., Grünberger, M., Steindl, R., Heibl, S., Thaler, J., Haushofer, A."Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report". Molecular and Clinical Oncology 19.2 (2023): 62.
Chicago
Strasser, B., Grünberger, M., Steindl, R., Heibl, S., Thaler, J., Haushofer, A."Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report". Molecular and Clinical Oncology 19, no. 2 (2023): 62. https://doi.org/10.3892/mco.2023.2658