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Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma

  • Authors:
    • Ryusuke Sumiya
    • Kazuhiko Yamada
    • Teruki Hagiwara
    • Satoshi Nagasaka
    • Hideki Miyazaki
    • Toru Igari
    • Yuki I. Kawamura
  • View Affiliations / Copyright

    Affiliations: Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, Japan, Department of Surgery, National Center for Global Health and Medicine, Tokyo 162-8655, Japan, Department of Thoracic Surgery, National Center for Global Health and Medicine, Tokyo 162-8655, Japan, Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
    Copyright: © Sumiya et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 64
    |
    Published online on: July 6, 2023
       https://doi.org/10.3892/mco.2023.2660
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Abstract

Lung squamous cell carcinoma (LSCC) is associated with poor prognosis. Molecular targeting drugs have been demonstrated to be effective for lung adenocarcinoma; however, they are often not effective for LSCC. Kallikrein-related peptidase 13 (KLK13) expression enhances the malignancy of lung adenocarcinoma; however, its expression and crucial role in LSCC remain largely unknown. The present study examined the relationship between the KLK13 expression and clinicopathological features of LSCC. A total of 94 patients diagnosed with LSCC who underwent lobectomy, segmentectomy or wedge resection were selected. KLK13 expression was evaluated through immunostaining of formalin-fixed paraffin-embedded sections of surgical specimens. Of the 94 LSCC samples, 70 exhibited no KLK13 expression, while the remaining 24 exhibited ectopic expression. KLK13 expression in tumors was focal and restricted to the cytoplasm of keratinized cells. LSCC cases were classified into KLK13-negative and KLK13-positive groups, and KLK13 expression was positively associated with E-cadherin expression (P=0.0143). Associations between KLK13 expression and keratinization (P=0.0052) or absence of lymphatic vessel invasion (P=0.0603) were observed; however, these trends did not reach statistical significance. The present findings indicated that KLK13 expression in keratinized LSCC may have a protective role in lymphatic vessel invasion of LSCC, which suggests its significance for therapeutic applications against LSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Sumiya R, Yamada K, Hagiwara T, Nagasaka S, Miyazaki H, Igari T and Kawamura YI: Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma. Mol Clin Oncol 19: 64, 2023.
APA
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., & Kawamura, Y.I. (2023). Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma. Molecular and Clinical Oncology, 19, 64. https://doi.org/10.3892/mco.2023.2660
MLA
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., Kawamura, Y. I."Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma". Molecular and Clinical Oncology 19.2 (2023): 64.
Chicago
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., Kawamura, Y. I."Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma". Molecular and Clinical Oncology 19, no. 2 (2023): 64. https://doi.org/10.3892/mco.2023.2660
Copy and paste a formatted citation
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Spandidos Publications style
Sumiya R, Yamada K, Hagiwara T, Nagasaka S, Miyazaki H, Igari T and Kawamura YI: Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma. Mol Clin Oncol 19: 64, 2023.
APA
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., & Kawamura, Y.I. (2023). Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma. Molecular and Clinical Oncology, 19, 64. https://doi.org/10.3892/mco.2023.2660
MLA
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., Kawamura, Y. I."Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma". Molecular and Clinical Oncology 19.2 (2023): 64.
Chicago
Sumiya, R., Yamada, K., Hagiwara, T., Nagasaka, S., Miyazaki, H., Igari, T., Kawamura, Y. I."Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma". Molecular and Clinical Oncology 19, no. 2 (2023): 64. https://doi.org/10.3892/mco.2023.2660
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