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Review Open Access

New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review)

  • Authors:
    • Jiang-Shan Zhou
    • Zi-Ning Liu
    • Yuan-Yuan Chen
    • Yu-Xi Liu
    • Hua Shen
    • Li-Jun Hou
    • Yi Ding
  • View Affiliations / Copyright

    Affiliations: Laboratory of Pathophysiology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Laboratory of Pathophysiology, Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Mathematics and Statistics, University of Calgary, Alberta T2N 1N4, Canada
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
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    Published online on: July 24, 2023
       https://doi.org/10.3892/mco.2023.2667
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Abstract

Breast cancer stands as the most prevalent form of cancer affecting women, with metastasis serving as a leading cause of mortality among patients with breast cancer. Gaining a comprehensive understanding of the metastatic mechanism in breast cancer is essential for early detection and precision treatment of the disease. Circulating tumor cells (CTCs) play a vital role in this context, representing cancer cells that detach from tumor tissues and enter the bloodstream of cancer patients. These cells travel in the blood circulation as single cells or clusters. Recent research has shed light on the enhanced metastatic potential of CTC clusters compared to single CTCs, despite their limited occurrence. The aim of the present review was to explore recent findings on CTCs with a particular focus on the clustering phenomenon of CTCs observed in breast cancer. Additionally, the present review delved into the comparison between single CTCs and CTC clusters regarding their implications for the treatment and prognosis of patients diagnosed with metastatic breast cancer. By examining the role and mechanisms of CTCs in breast cancer metastasis, the present review provided an improved understanding of CTCs and their significance in early detection of breast cancer metastasis through peripheral blood analysis. Moreover, it contributed to the comprehension of cancer prognosis and prediction by highlighting the implications of CTCs in these aspects. Ultimately, the present study seeks to advance knowledge in the field and pave the way for improved approaches to breast cancer management.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Liu Z, Chen Y, Liu Y, Shen H, Hou L and Ding Y: New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review). Mol Clin Oncol 19: 71, 2023.
APA
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., & Ding, Y. (2023). New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review). Molecular and Clinical Oncology, 19, 71. https://doi.org/10.3892/mco.2023.2667
MLA
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., Ding, Y."New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review)". Molecular and Clinical Oncology 19.3 (2023): 71.
Chicago
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., Ding, Y."New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review)". Molecular and Clinical Oncology 19, no. 3 (2023): 71. https://doi.org/10.3892/mco.2023.2667
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Liu Z, Chen Y, Liu Y, Shen H, Hou L and Ding Y: New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review). Mol Clin Oncol 19: 71, 2023.
APA
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., & Ding, Y. (2023). New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review). Molecular and Clinical Oncology, 19, 71. https://doi.org/10.3892/mco.2023.2667
MLA
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., Ding, Y."New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review)". Molecular and Clinical Oncology 19.3 (2023): 71.
Chicago
Zhou, J., Liu, Z., Chen, Y., Liu, Y., Shen, H., Hou, L., Ding, Y."New advances in circulating tumor cell‑mediated metastasis of breast cancer (Review)". Molecular and Clinical Oncology 19, no. 3 (2023): 71. https://doi.org/10.3892/mco.2023.2667
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