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Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma

  • Authors:
    • Aikaterini Aravantinou-Fatorou
    • Vasiliki Epameinondas Georgakopoulou
    • Nikolaos Mathioudakis
    • Petros Papalexis
    • Kyriakos Tarantinos
    • Ilias Trakas
    • Nikolaos Trakas
    • Demetrios A. Spandidos
    • George Fotakopoulos
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, Department of Infectious Diseases and COVID-19 Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, Department of Renal Transplantation, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece, First Pulmonology Department, Sismanogleio Hospital, Athens 15126, Greece, Department of Biochemistry, Sismanogleio Hospital, Athens 15126, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece, Department of Neurosurgery, General University Hospital of Larisa, Larisa 41221, Greece
    Copyright: © Aravantinou-Fatorou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 73
    |
    Published online on: July 26, 2023
       https://doi.org/10.3892/mco.2023.2669
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Abstract

Glioblastoma multiforme (GBM) is the most frequent and malignant primary central nervous system tumor in adults. The gold‑standard management of GBM includes post‑operative radiotherapy (RT) with concurrent and secondary temozolomide (TMZ) treatment. The present meta‑analysis study examined the efficacy of the early administration of bevacizumab prior to standard RT plus TMZ in managing patients with GBM and unfavorable prognostic factors. Between 1983 and 2020, the present study looked for comparative articles involving standard RT plus TMZ and RT/TMZ combined with bevacizumab treatment in patients with GBM. The primary outcomes involved in this study include progression‑free survival and overall survival. The present study suggested that bevacizumab administration plus standard RT/TMZ (BEV group) treatment was associated with increased survival of patients with GBM compared with those treated with standard RT/TMZ (CG/Control group) treatment only.
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Copy and paste a formatted citation
Spandidos Publications style
Aravantinou-Fatorou A, Georgakopoulou VE, Mathioudakis N, Papalexis P, Tarantinos K, Trakas I, Trakas N, Spandidos DA and Fotakopoulos G: Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma. Mol Clin Oncol 19: 73, 2023.
APA
Aravantinou-Fatorou, A., Georgakopoulou, V.E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I. ... Fotakopoulos, G. (2023). Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma. Molecular and Clinical Oncology, 19, 73. https://doi.org/10.3892/mco.2023.2669
MLA
Aravantinou-Fatorou, A., Georgakopoulou, V. E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I., Trakas, N., Spandidos, D. A., Fotakopoulos, G."Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma". Molecular and Clinical Oncology 19.3 (2023): 73.
Chicago
Aravantinou-Fatorou, A., Georgakopoulou, V. E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I., Trakas, N., Spandidos, D. A., Fotakopoulos, G."Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma". Molecular and Clinical Oncology 19, no. 3 (2023): 73. https://doi.org/10.3892/mco.2023.2669
Copy and paste a formatted citation
x
Spandidos Publications style
Aravantinou-Fatorou A, Georgakopoulou VE, Mathioudakis N, Papalexis P, Tarantinos K, Trakas I, Trakas N, Spandidos DA and Fotakopoulos G: Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma. Mol Clin Oncol 19: 73, 2023.
APA
Aravantinou-Fatorou, A., Georgakopoulou, V.E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I. ... Fotakopoulos, G. (2023). Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma. Molecular and Clinical Oncology, 19, 73. https://doi.org/10.3892/mco.2023.2669
MLA
Aravantinou-Fatorou, A., Georgakopoulou, V. E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I., Trakas, N., Spandidos, D. A., Fotakopoulos, G."Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma". Molecular and Clinical Oncology 19.3 (2023): 73.
Chicago
Aravantinou-Fatorou, A., Georgakopoulou, V. E., Mathioudakis, N., Papalexis, P., Tarantinos, K., Trakas, I., Trakas, N., Spandidos, D. A., Fotakopoulos, G."Comparison of the outcomes following bevacizumab and/or temozolamide/radiosurgery treatment in patients with glioblastoma". Molecular and Clinical Oncology 19, no. 3 (2023): 73. https://doi.org/10.3892/mco.2023.2669
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