Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy

Makita,Kenji; Hamamoto,Yasushi; Kanzaki,Hiromitsu; Nagasaki,Kei; Hashine,Katsuyoshi

doi:10.3892/mco.2023.2674

Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy

Authors:
- Kenji Makita
- Yasushi Hamamoto
- Hiromitsu Kanzaki
- Kei Nagasaki
- Katsuyoshi Hashine
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Affiliations: Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan, Department of Urology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan
Published online on: August 23, 2023 https://doi.org/10.3892/mco.2023.2674
Article Number: 78
Copyright: © Makita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The influence of a hydrogel spacer (HS) on seminal vesicle (SV) displacement in prostate radiotherapy was examined in the present study. A total of 20 patients with prostate cancer, who received intensity‑modulated radiation therapy (IMRT), were enrolled. Computed tomography and magnetic resonance imaging were performed before and after HS insertion within the peripheral space for IMRT planning. Before and after HS insertion, The SV was delineated, and the amount of SV displacement was evaluated. Large SV cranial displacements (≥0.50 cm) were observed in 25% of patients. A HS lateral distribution of ≥1.00 cm in the upper two slices (midgland + superior) influenced the SV cranial displacements (P<0.01) and was associated with large SV cranial displacements (≥0.5 cm) (P<0.01). The HS cranial distribution in the upper slices did not influence SV cranial displacements (P=0.16). In addition, any HS lateral distribution of ≥1.00 cm in all slices did not induce the SV lateral and anterior‑posterior displacements (P=0.50 and 0.70, respectively). In conclusion, SV cranial displacement was influenced by HS lateral distribution of ≥1.00 cm in the upper two slices. Therefore, when the sigmoid colon or small bowel is depressed in rectovesical excavation and SV needs to be included in the target volume, HS insertion should be performed carefully.

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