Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2023 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2023 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma

  • Authors:
    • Kenji Imai
    • Koji Takai
    • Shinji Unome
    • Takao Miwa
    • Tatsunori Hanai
    • Atsushi Suetsugu
    • Masahito Shimizu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu 501‑1194, Japan
    Copyright: © Imai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 80
    |
    Published online on: August 24, 2023
       https://doi.org/10.3892/mco.2023.2676
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑viral hepatocellular carcinoma (HCC) tends to appear in non‑cirrhotic livers, rendering it difficult to screen for a high‑risk group. The present study aimed to identify the most suitable indicator for screening high‑risk groups of non‑viral HCC. A total of 190 patients with non‑viral HCC, including 126 with non‑alcoholic fatty liver disease (NAFLD)/non‑alcoholic steatohepatitis (NASH), were enrolled in the present study. A total of two cut‑off values, for low and high levels of fibrosis, were set for each of the indicators, including the Child‑Pugh score (CPS; 6 and 7), platelet counts (15.8 and 10x104/µl), albumin‑bilirubin (ALBI) score (‑2.60 and ‑2.27), fibrosis 4 index (FIB‑4 index; 1.30 and 2.67) and NAFLD fibrosis score (NFS; ‑1.455 and 0.675). The ratio of the number of patients who fell outside the cut‑off value for all patients was defined as the overlooking rate. The overlooking rates of CPS, platelet counts, ALBI score, FIB‑4 index and NFS for the low fibrosis cut‑off value were 41.0, 48.9, 35.8, 4.2 and 5.8%, respectively. When performing analysis limited to the NAFLD cases, those of the FIB‑4 index and NFS were 4.8 and 6.3%, respectively. Those for the high fibrosis cut‑off value were 79.5, 73.2, 62.6, 30.0 and 37.4%, respectively. On the whole, the present study demonstrates that the cut‑off values of ≥1.30 for the FIB‑4 index or ≥‑1.455 for the NFS may be used to screen high‑risk groups of HCC among patients with non‑viral hepatitis.
View Figures

Figure 1

View References

1 

El-Serag HB: Hepatocellular carcinoma: An epidemiologic view. J Clin Gastroenterol. 35:S72–S78. 2002.PubMed/NCBI View Article : Google Scholar

2 

Falade-Nwulia O, Suarez-Cuervo C, Nelson DR, Fried MW, Segal JB and Sulkowski MS: Oral direct-acting agent therapy for hepatitis c virus infection: A systematic review. Ann Intern Med. 166:637–648. 2017.PubMed/NCBI View Article : Google Scholar

3 

Blüher M: Obesity: Global epidemiology and pathogenesis. Nat Rev Endocrinol. 15:288–298. 2019.PubMed/NCBI View Article : Google Scholar

4 

Mittal S and El-Serag HB: Epidemiology of hepatocellular carcinoma: Consider the population. J Clin Gastroenterol. 47 (Suppl):S2–S6. 2013.PubMed/NCBI View Article : Google Scholar

5 

Tateishi R, Uchino K, Fujiwara N, Takehara T, Okanoue T, Seike M, Yoshiji H, Yatsuhashi H, Shimizu M, Torimura T, et al: A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update. J Gastroenterol. 54:367–376. 2019.PubMed/NCBI View Article : Google Scholar

6 

Sanyal A, Poklepovic A, Moyneur E and Barghout V: Population-based risk factors and resource utilization for HCC: US perspective. Curr Med Res Opin. 26:2183–2191. 2010.PubMed/NCBI View Article : Google Scholar

7 

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L and Wymer M: Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 64:73–84. 2016.PubMed/NCBI View Article : Google Scholar

8 

Kokudo N, Takemura N, Hasegawa K, Takayama T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, et al: Clinical practice guidelines for hepatocellular carcinoma: The Japan society of hepatology 2017 (4th JSH-HCC guidelines) 2019 update. Hepatol Res. 49:1109–1113. 2019.PubMed/NCBI View Article : Google Scholar

9 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu; European Association for the Study of the Liver. EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 69:182–236. 2018.PubMed/NCBI View Article : Google Scholar

10 

Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH and Marrero JA: AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 67:358–380. 2018.PubMed/NCBI View Article : Google Scholar

11 

Karagozian R, Derdák Z and Baffy G: Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism. 63:607–617. 2014.PubMed/NCBI View Article : Google Scholar

12 

Hiraoka A, Kumada T, Michitaka K and Kudo M: Newly proposed ALBI grade and ALBI-T score as tools for assessment of hepatic function and prognosis in hepatocellular carcinoma patients. Liver Cancer. 8:312–325. 2019.PubMed/NCBI View Article : Google Scholar

13 

Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, et al: Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population. BMC Gastroenterol. 12(2)2012.PubMed/NCBI View Article : Google Scholar

14 

Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, Enders F, Saksena S, Burt AD, Bida JP, et al: The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 45:846–854. 2007.PubMed/NCBI View Article : Google Scholar

15 

Tokushige K, Ikejima K, Ono M, Eguchi Y, Kamada Y, Itoh Y, Akuta N, Yoneda M, Iwasa M, Yoneda M, et al: Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020. Hepatol Res. 51:1013–1025. 2021.PubMed/NCBI View Article : Google Scholar

16 

Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M and Sanyal AJ: The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American association for the study of liver diseases, American college of gastroenterology, and the American gastroenterological association. Hepatology. 55:2005–2023. 2012.PubMed/NCBI View Article : Google Scholar

17 

Francque SM, Marchesini G, Kautz A, Walmsley M, Dorner R, Lazarus JV, Zelber-Sagi S, Hallsworth K, Busetto L, Frühbeck G, et al: Non-alcoholic fatty liver disease: A patient guideline. JHEP Rep. 3(100322)2021.PubMed/NCBI View Article : Google Scholar

18 

Tokushige K, Ikejima K, Ono M, Eguchi Y, Kamada Y, Itoh Y, Akuta N, Yoneda M, Iwasa M, Yoneda M, et al: Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020. J Gastroenterol. 56:951–963. 2021.PubMed/NCBI View Article : Google Scholar

19 

Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M, Inoue O, Yano M, Tanaka M, Fujiyama S, et al: Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study group. inhibition of hepatocarcinogenesis by interferon therapy. Ann Intern Med. 131:174–181. 1999.PubMed/NCBI View Article : Google Scholar

20 

Shiratori Y, Imazeki F, Moriyama M, Yano M, Arakawa Y, Yokosuka O, Kuroki T, Nishiguchi S, Sata M, Yamada G, et al: Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy. Ann Intern Med. 132:517–524. 2000.PubMed/NCBI View Article : Google Scholar

21 

Xiao G, Zhu S, Xiao X, Yan L, Yang J and Wu G: Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: A meta-analysis. Hepatology. 66:1486–1501. 2017.PubMed/NCBI View Article : Google Scholar

22 

Imai K, Takai K, Miwa T, Maeda T, Hanai T, Shiraki M, Suetsugu A and Shimizu M: Increased visceral adipose tissue and hyperinsulinemia raise the risk for recurrence of Non-B Non-C hepatocellular carcinoma after curative treatment. Cancers (Basel). 13(1542)2021.PubMed/NCBI View Article : Google Scholar

23 

Imai K, Takai K, Maeda T, Watanabe S, Hanai T, Suetsugu A, Shiraki M and Shimizu M: Increased visceral fat volume raises the risk for recurrence of hepatocellular carcinoma after curative treatment. Oncotarget. 9:14058–14067. 2018.PubMed/NCBI View Article : Google Scholar

24 

Imai K, Takai K, Hanai T, Suetsugu A, Shiraki M and Shimizu M: Homeostatic model assessment of insulin resistance for predicting the recurrence of hepatocellular carcinoma after curative treatment. Int J Mol Sci. 20(605)2019.PubMed/NCBI View Article : Google Scholar

25 

Suzuki Y, Imai K, Takai K, Hanai T, Hayashi H, Naiki T, Nishigaki Y, Tomita E, Shimizu M and Moriwaki H: Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: A prospective case series study using the d-ROM test. J Cancer Res Clin Oncol. 139:845–852. 2013.PubMed/NCBI View Article : Google Scholar

26 

Watanabe N, Takai K, Imai K, Shimizu M, Naiki T, Nagaki M and Moriwaki H: Increased levels of serum leptin are a risk factor for the recurrence of stage I/II hepatocellular carcinoma after curative treatment. J Clin Biochem Nutr. 49:153–158. 2011.PubMed/NCBI View Article : Google Scholar

27 

Fluss R, Faraggi D and Reiser B: Estimation of the Youden Index and its associated cutoff point. Biom J. 47:458–472. 2005.PubMed/NCBI View Article : Google Scholar

28 

Cao L, Cheng H, Jiang Q, Li H and Wu Z: APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinoma. Aging (Albany NY). 12:4573–4591. 2020.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Imai K, Takai K, Unome S, Miwa T, Hanai T, Suetsugu A and Shimizu M: FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma. Mol Clin Oncol 19: 80, 2023.
APA
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., & Shimizu, M. (2023). FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma. Molecular and Clinical Oncology, 19, 80. https://doi.org/10.3892/mco.2023.2676
MLA
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., Shimizu, M."FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma". Molecular and Clinical Oncology 19.4 (2023): 80.
Chicago
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., Shimizu, M."FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma". Molecular and Clinical Oncology 19, no. 4 (2023): 80. https://doi.org/10.3892/mco.2023.2676
Copy and paste a formatted citation
x
Spandidos Publications style
Imai K, Takai K, Unome S, Miwa T, Hanai T, Suetsugu A and Shimizu M: FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma. Mol Clin Oncol 19: 80, 2023.
APA
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., & Shimizu, M. (2023). FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma. Molecular and Clinical Oncology, 19, 80. https://doi.org/10.3892/mco.2023.2676
MLA
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., Shimizu, M."FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma". Molecular and Clinical Oncology 19.4 (2023): 80.
Chicago
Imai, K., Takai, K., Unome, S., Miwa, T., Hanai, T., Suetsugu, A., Shimizu, M."FIB‑4 index and NAFLD fibrosis score are useful indicators for screening high‑risk groups of non‑viral hepatocellular carcinoma". Molecular and Clinical Oncology 19, no. 4 (2023): 80. https://doi.org/10.3892/mco.2023.2676
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team