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Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy

  • Authors:
    • Heng Xu
    • Haixia Cao
    • Junying Zhang
    • Changwen Jing
    • Zhuo Wang
    • Jianzhong Wu
    • Mengjie Du
    • Xuyun Xu
    • Rong Ma
  • View Affiliations / Copyright

    Affiliations: Jiangsu Provincial Institute of Materia Medica, Nanjing Tech University, Nanjing, Jiangsu 210000, P.R. China, Research Center for Clinical Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210000, P.R. China, Nanjing Runtai Clinical Laboratory, Nanjing, Jiangsu 210000, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 86
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    Published online on: September 15, 2023
       https://doi.org/10.3892/mco.2023.2682
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Abstract

The present study evaluated serum levels of vascular endothelial growth factor (VEGF) as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma (ESCC) following curative esophagectomy followed by chemotherapy or concurrent radiotherapy. Patients with locally advanced resectable ESCC underwent R0 esophagectomy followed by chemotherapy or concurrent radiotherapy as an adjuvant. Serum VEGF levels in 173 patients, including 57 patients with recurrent disease, and 183 healthy controls were determined using a Luminex assay. The results demonstrated that the serum VEGF levels were significantly higher in 57 patients with locally advanced resectable ESCC at recurrence compared with the levels at pre‑treatment (P<0.001). The patients with recurrence exhibited significantly higher serum VEGF levels during chemotherapy or concurrent radiotherapy than patients with no recurrence (P<0.05). Patients with low serum VEGF levels had a significantly longer survival time than those with high serum VEGF levels prior to treatment (P<0.01). The median survival times were 70 and 25 months in patients with locally advanced resectable ESCC with serum VEGF levels <161.75 and ≥161.75 pg/ml following treatment, respectively (P<0.01). Compared with patients with VEGF levels <147 pg/ml following treatment, patients with locally advanced resectable ESCC with VEGF levels ≥147 pg/ml had a significantly higher risk of recurrence (P<0.01). Patients with low serum VEGF levels (<147 pg/ml) had significantly higher recurrence‑free survival rates than those with high serum VEGF levels (≥147 pg/ml) following treatment (P<0.01). The findings of the present study demonstrate that serum VEGF levels are a potential predictor of recurrence and of the treatment outcomes of chemotherapy or concurrent radiotherapy in patients with locally advanced resectable ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Xu H, Cao H, Zhang J, Jing C, Wang Z, Wu J, Du M, Xu X and Ma R: Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy. Mol Clin Oncol 19: 86, 2023.
APA
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J. ... Ma, R. (2023). Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy. Molecular and Clinical Oncology, 19, 86. https://doi.org/10.3892/mco.2023.2682
MLA
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J., Du, M., Xu, X., Ma, R."Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy". Molecular and Clinical Oncology 19.5 (2023): 86.
Chicago
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J., Du, M., Xu, X., Ma, R."Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy". Molecular and Clinical Oncology 19, no. 5 (2023): 86. https://doi.org/10.3892/mco.2023.2682
Copy and paste a formatted citation
x
Spandidos Publications style
Xu H, Cao H, Zhang J, Jing C, Wang Z, Wu J, Du M, Xu X and Ma R: Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy. Mol Clin Oncol 19: 86, 2023.
APA
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J. ... Ma, R. (2023). Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy. Molecular and Clinical Oncology, 19, 86. https://doi.org/10.3892/mco.2023.2682
MLA
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J., Du, M., Xu, X., Ma, R."Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy". Molecular and Clinical Oncology 19.5 (2023): 86.
Chicago
Xu, H., Cao, H., Zhang, J., Jing, C., Wang, Z., Wu, J., Du, M., Xu, X., Ma, R."Serum VEGF levels as a predictor of recurrence in patients with advanced‑stage esophageal squamous cell carcinoma following curative esophagectomy followed by chemotherapy or concurrent radiotherapy". Molecular and Clinical Oncology 19, no. 5 (2023): 86. https://doi.org/10.3892/mco.2023.2682
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