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Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma

  • Authors:
    • Jinping Lu
    • Ting Kang
    • Zhenlin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory and Medical Research Center, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong 519000, P.R. China, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 516060, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 89
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    Published online on: September 22, 2023
       https://doi.org/10.3892/mco.2023.2685
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Abstract

Aldo‑keto reductase family 1 member B10 (AKR1B10) is a potential marker of several types of cancer; however, the role of AKR1B10 in nasopharyngeal carcinoma (NPC) remains unclear. In the present study, AKR1B10 RNA‑seq data and clinical information were obtained from The Cancer Genome Atlas head and neck squamous cell carcinoma (HNSCC) database to evaluate the role of AKR1B10 in HNSCC. There was no statistically significant difference in the expression of AKR1B10 between HNSCC tissues and adjacent normal tissues, and high AKR1B10 expression was not associated with poor overall survival according to the public database. The present study further examined the role of AKR1B10 in patients with NPC using data obtained from the Gene Expression Omnibus database. Analysis of the GSE53819 and GSE61218 datasets showed that the there were no significant differences in the expression levels of AKR1B10 between NPC tissues and normal tissues. However, analysis of the GSE103611 dataset indicated that AKR1B10 may be associated with distance metastasis following radical treatment in NPC. Finally, serum samples from patients with NPC and healthy controls were collected and analyzed. The results revealed that AKR1B10 levels were significantly increased in samples from patients with NPC compared with those from healthy controls, and the area under the receiver operating characteristic curve was 0.909. In conclusion, unlike tissue AKR1B10 expression, serum AKR1B10 levels may be a promising biomarker for the diagnosis of NPC.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI View Article : Google Scholar

2 

Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019.PubMed/NCBI View Article : Google Scholar

3 

Chua MLK, Wee JTS, Hui EP and Chan ATC: Nasopharyngeal carcinoma. Lancet. 387:1012–1024. 2016.PubMed/NCBI View Article : Google Scholar

4 

Wee JT, Ha TC, Loong SL and Qian CN: Is nasopharyngeal cancer really a ‘Cantonese cancer’? Chin J Cancer. 29:517–526. 2010.PubMed/NCBI View Article : Google Scholar

5 

Cao D, Fan ST and Chung SS: Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem. 273:11429–11435. 1998.PubMed/NCBI View Article : Google Scholar

6 

Scuric Z, Stain SC, Anderson WF and Hwang JJ: New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma. Hepatology. 27:943–950. 1998.PubMed/NCBI View Article : Google Scholar

7 

Wang R, Wang G, Ricard MJ, Ferris B, Strulovici-Barel Y, Salit J, Hackett NR, Gudas LJ and Crystal RG: Smoking-Induced Upregulation of AKR1B10 expression in the airway epithelium of healthy individuals. Chest. 138:1402–1410. 2010.PubMed/NCBI View Article : Google Scholar

8 

Zhang W, Li H, Yang Y, Liao J and Yang GY: Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway. Cancer Lett. 355:273–280. 2014.PubMed/NCBI View Article : Google Scholar

9 

Wang C, Yan R, Luo D, Watabe K, Liao DF and Cao D: Aldo-keto reductase family 1 member B10 promotes cell survival by regulating lipid synthesis and eliminating carbonyls. J Biol Chem. 284:26742–26748. 2009.PubMed/NCBI View Article : Google Scholar

10 

Ye X, Li C, Zu X, Lin M, Liu Q, Liu J, Xu G, Chen Z, Xu Y, Liu L, et al: A large-scale multicenter study validates aldo-keto reductase family 1 member B10 as a prevalent serum marker for detection of hepatocellular carcinoma. Hepatology. 69:2489–2501. 2019.PubMed/NCBI View Article : Google Scholar

11 

van Weverwijk A, Koundouros N, Iravani M, Ashenden M, Gao Q, Poulogiannis G, Jungwirth U and Isacke CM: Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. Nat Commun. 10(2698)2019.PubMed/NCBI View Article : Google Scholar

12 

Qu J, Li J, Zhang Y, He R, Liu X, Gong K, Duan L, Luo W, Hu Z, Wang G, et al: AKR1B10 promotes breast cancer cell proliferation and migration via the PI3K/AKT/NF-kappaB signaling pathway. Cell Biosci. 11(163)2021.PubMed/NCBI View Article : Google Scholar

13 

Huang C, Cao Z, Ma J, Shen Y, Bu Y, Khoshaba R, Shi G, Huang D, Liao DF, Ji H, et al: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. Mol Carcinog. 57:1300–1310. 2018.PubMed/NCBI View Article : Google Scholar

14 

Ahmed SMU, Jiang ZN, Zheng ZH, Li Y, Wang XJ and Tang X: AKR1B10 expression predicts response of gastric cancer to neoadjuvant chemotherapy. Oncol Lett. 17:773–780. 2019.PubMed/NCBI View Article : Google Scholar

15 

Hung JJ, Yeh YC and Hsu WH: Prognostic significance of AKR1B10 in patients with resected lung adenocarcinoma. Thorac Cancer. 9:1492–1499. 2018.PubMed/NCBI View Article : Google Scholar

16 

Liu W, Song J, Du X, Zhou Y, Li Y, Li R, Lyu L, He Y, Hao J, Ben J, et al: AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model. Acta Biomater. 91:195–208. 2019.PubMed/NCBI View Article : Google Scholar

17 

Fukumoto S, Yamauchi N, Moriguchi H, Hippo Y, Watanabe A, Shibahara J, Taniguchi H, Ishikawa S, Ito H, Yamamoto S, et al: Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. Clin Cancer Res. 11:1776–1785. 2005.PubMed/NCBI View Article : Google Scholar

18 

Chung YT, Matkowskyj KA, Li H, Bai H, Zhang W, Tsao MS, Liao J and Yang GY: Overexpression and oncogenic function of aldo-keto reductase family 1B10 (AKR1B10) in pancreatic carcinoma. Mod Pathol. 25:758–766. 2012.PubMed/NCBI View Article : Google Scholar

19 

Ko HH, Cheng SL, Lee JJ, Chen HM, Kuo MY and Cheng SJ: Expression of AKR1B10 as an independent marker for poor prognosis in human oral squamous cell carcinoma. Head Neck. 39:1327–1332. 2017.PubMed/NCBI View Article : Google Scholar

20 

Ko HH, Peng HH, Cheng SJ and Kuo MY: Increased salivary AKR1B10 level: Association with progression and poor prognosis of oral squamous cell carcinoma. Head Neck. 40:2642–2647. 2018.PubMed/NCBI View Article : Google Scholar

21 

Fang CY, Lin YH and Chen CL: Overexpression of AKR1B10 predicts tumor recurrence and short survival in oral squamous cell carcinoma patients. J Oral Pathol Med. 48:712–719. 2019.PubMed/NCBI View Article : Google Scholar

22 

Liu J, Ban H, Liu Y and Ni J: The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma. Sci Rep. 11(18228)2021.PubMed/NCBI View Article : Google Scholar

23 

Taskoparan B, Seza EG, Demirkol S, Tuncer S, Stefek M, Gure AO and Banerjee S: Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer. Cell Oncol (Dordr). 40:563–578. 2017.PubMed/NCBI View Article : Google Scholar

24 

Zu X, Yan R, Pan J, Zhong L, Cao Y, Ma J, Cai C, Huang D, Liu J, Chung FL, et al: Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds. Mol Carcinog. 56:118–129. 2017.PubMed/NCBI View Article : Google Scholar

25 

Sinreih M, Stupar S, Cemazar L, Verdenik I, Frkovic Grazio S, Smrkolj S and Rizner TL: STAR and AKR1B10 are down-regulated in high-grade endometrial cancer. J Steroid Biochem Mol Biol. 171:43–53. 2017.PubMed/NCBI View Article : Google Scholar

26 

Hojnik M, Frkovic Grazio S, Verdenik I and Rizner TL: AKR1B1 and AKR1B10 as prognostic biomarkers of endometrioid endometrial carcinomas. Cancers (Basel). 13(3398)2021.PubMed/NCBI View Article : Google Scholar

27 

Guo Y, Luo W, Hu Z, Li J, Li X, Cao H, Li J, Wen B, Zhang J, Cheng H, et al: Low expression of Aldo-keto reductase 1B10 is a novel independent prognostic indicator for nasopharyngeal carcinoma. Cell Biosci. 6(18)2016.PubMed/NCBI View Article : Google Scholar

28 

He YC, Shen Y, Cao Y, Tang FQ, Tian DF, Huang CF, Tao H, Zhou FL, Zhang B, Song L, et al: Overexpression of AKR1B10 in nasopharyngeal carcinoma as a potential biomarker. Cancer Biomark. 16:127–135. 2016.PubMed/NCBI View Article : Google Scholar

29 

Bao YN, Cao X, Luo DH, Sun R, Peng LX, Wang L, Yan YP, Zheng LS, Xie P, Cao Y, et al: Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 13:1958–1969. 2014.PubMed/NCBI View Article : Google Scholar

30 

Fan C, Wang J, Tang Y, Zhang S, Xiong F, Guo C, Zhou Y, Li Z, Li X, Li Y, et al: Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers. BMC Cancer. 20(917)2020.PubMed/NCBI View Article : Google Scholar

31 

Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, Tang LL, Mao YP, He QM, Yang XJ, et al: Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: A retrospective, multicentre, cohort study. Lancet Oncol. 19:382–393. 2018.PubMed/NCBI View Article : Google Scholar

32 

Endo S, Matsunaga T and Nishinaka T: The Role of AKR1B10 in physiology and pathophysiology. Metabolites. 11(332)2021.PubMed/NCBI View Article : Google Scholar

33 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 6(92)2020.PubMed/NCBI View Article : Google Scholar

34 

Liu X, Hu Z, Qu J, Li J, Gong K, Wang L, Jiang J, Li X, He R, Duan L, et al: AKR1B10 confers resistance to radiotherapy via FFA/TLR4/NF-κB axis in nasopharyngeal carcinoma. Int J Biol Sci. 17:756–767. 2021.PubMed/NCBI View Article : Google Scholar

35 

Matsunaga T, Suzuki A, Kezuka C, Okumura N, Iguchi K, Inoue I, Soda M, Endo S, El-Kabbani O, Hara A and Ikari A: Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-ү-dependent mechanism. Chem Biol Interact. 256:142–153. 2016.PubMed/NCBI View Article : Google Scholar

36 

Morikawa Y, Kezuka C, Endo S, Ikari A, Soda M, Yamamura K, Toyooka N, El-Kabbani O, Hara A and Matsunaga T: Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo-keto reductase 1B10. Chem Biol Interact. 230:30–39. 2015.PubMed/NCBI View Article : Google Scholar

37 

Matsunaga T, Yamaji Y, Tomokuni T, Morita H, Morikawa Y, Suzuki A, Yonezawa A, Endo S, Ikari A, Iguchi K, et al: Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome. Free Radic Res. 48:1371–1385. 2014.PubMed/NCBI View Article : Google Scholar

38 

Yao Y, Wang X, Zhou D, Li H, Qian H, Zhang J, Jiang L, Wang B, Lin Q and Zhu X: Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway. Aging (Albany NY). 12:13059–13075. 2020.PubMed/NCBI View Article : Google Scholar

39 

Jin J, Liao W, Yao W, Zhu R, Li Y and He S: Aldo-keto reductase family 1 member B 10 mediates liver cancer cell proliferation through sphingosine-1-phosphate. Sci Rep. 6(22746)2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lu J, Kang T and Zhang Z: Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Mol Clin Oncol 19: 89, 2023.
APA
Lu, J., Kang, T., & Zhang, Z. (2023). Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Molecular and Clinical Oncology, 19, 89. https://doi.org/10.3892/mco.2023.2685
MLA
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19.5 (2023): 89.
Chicago
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19, no. 5 (2023): 89. https://doi.org/10.3892/mco.2023.2685
Copy and paste a formatted citation
x
Spandidos Publications style
Lu J, Kang T and Zhang Z: Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Mol Clin Oncol 19: 89, 2023.
APA
Lu, J., Kang, T., & Zhang, Z. (2023). Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma. Molecular and Clinical Oncology, 19, 89. https://doi.org/10.3892/mco.2023.2685
MLA
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19.5 (2023): 89.
Chicago
Lu, J., Kang, T., Zhang, Z."Diagnostic value of aldo‑keto reductase family 1 member B10 in human nasopharyngeal carcinoma". Molecular and Clinical Oncology 19, no. 5 (2023): 89. https://doi.org/10.3892/mco.2023.2685
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