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Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)

  • Authors:
    • Rayansh Poojary
    • Andy Fang Song
    • Benny Shone Song
    • Carly Shaw Song
    • Liqing Wang
    • Jianxun Song
  • View Affiliations / Copyright

    Affiliations: Department of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807-3260, USA
    Copyright: © Poojary et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 95
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    Published online on: October 12, 2023
       https://doi.org/10.3892/mco.2023.2691
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Abstract

Immunotherapy has emerged as a crucial treatment option, particularly for types of cancer that display resistance to conventional therapies. A remarkable breakthrough in this field is the development of chimeric antigen receptor (CAR) T cell therapy. CAR T cells are generated by engineering the T cells of a patient to express receptors that can recognize specific tumor antigens. This groundbreaking approach has demonstrated impressive outcomes in hematologic malignancies, including diffuse large B cell lymphoma, B cell acute lymphoblastic leukemia and multiple myeloma. Despite these significant successes, CAR T cell therapy has encountered challenges in its application against solid tumors, leading to limited success in these cases. Consequently, researchers are actively exploring novel strategies to enhance the efficacy of CAR T cells. The focus lies on augmenting CAR T cell trafficking to tumors while preventing the development of CAR T cell exhaustion and dysfunction. The present review aimed to provide a comprehensive analysis of the achievements and limitations of CAR T cell therapy in the context of cancer treatment. By understanding both the successes and hurdles, further advancements in this promising area of research can be developed. Overall, immunotherapy, particularly CAR T cell therapy, has opened up novel possibilities for cancer treatment, offering hope to patients with previously untreatable malignancies. However, to fully realize its potential, ongoing research and innovative strategies are essential in overcoming the challenges posed by solid tumors and maximizing CAR T cell efficacy in clinical settings.
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1 

Fuller R, Landrigan PJ, Balakrishnan K, Bathan G, Bose-O'Reilly S, Brauer M, Caravanos J, Chiles T, Cohen A, Corra L, et al: Pollution and health: A progress update. Lancet Planet Health. 6:e535–e547. 2022.PubMed/NCBI View Article : Google Scholar

2 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022.PubMed/NCBI View Article : Google Scholar

3 

Adams JL, Smothers J, Srinivasan R and Hoos A: Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 14:603–622. 2015.PubMed/NCBI View Article : Google Scholar

4 

Hoption Cann SA, van Netten JP and van Netten C: Dr William Coley and tumour regression: A place in history or in the future. Postgrad Med J. 79:672–680. 2003.PubMed/NCBI

5 

Fares J, Fares MY, Khachfe HH, Salhab HA and Fares Y: Molecular principles of metastasis: A hallmark of cancer revisited. Signal Transduct Target Ther. 5(28)2020.PubMed/NCBI View Article : Google Scholar

6 

Miller JF and Sadelain M: The journey from discoveries in fundamental immunology to cancer immunotherapy. Cancer Cell. 27:439–449. 2015.PubMed/NCBI View Article : Google Scholar

7 

Kyrysyuk O and Wucherpfennig KW: Designing cancer immunotherapies that engage T cells and NK cells. Annu Rev Immunol. 41:17–38. 2023.PubMed/NCBI View Article : Google Scholar

8 

Zagorulya M and Spranger S: Once upon a prime: DCs shape cancer immunity. Trends Cancer. 9:172–184. 2023.PubMed/NCBI View Article : Google Scholar

9 

Thommen DS and Schumacher TN: T Cell Dysfunction in Cancer. Cancer Cell. 33:547–562. 2018.PubMed/NCBI View Article : Google Scholar

10 

Briukhovetska D, Dorr J, Endres S, Libby P, Dinarello CA and Kobold S: Interleukins in cancer: From biology to therapy. Nat Rev Cancer. 21:481–499. 2021.PubMed/NCBI View Article : Google Scholar

11 

Takeuchi Y and Nishikawa H: Roles of regulatory T cells in cancer immunity. Int Immunol. 28:401–409. 2016.PubMed/NCBI View Article : Google Scholar

12 

Chow A, Perica K, Klebanoff CA and Wolchok JD: Clinical implications of T cell exhaustion for cancer immunotherapy. Nat Rev Clin Oncol. 19:775–790. 2022.PubMed/NCBI View Article : Google Scholar

13 

Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, Osawa T, Soga T, Taniguchi T and Yanai H: Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8(+) T cell activation. Proc Natl Acad Sci USA. 120(e2305245120)2023.PubMed/NCBI View Article : Google Scholar

14 

Maruhashi T, Sugiura D, Okazaki IM, Shimizu K, Maeda TK, Ikubo J, Yoshikawa H, Maenaka K, Ishimaru N, Kosako H, et al: Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. Immunity. 55:912–924 e8. 2022.PubMed/NCBI View Article : Google Scholar

15 

Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, et al: Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma. J Immunother Cancer. 10(e003198)2022.PubMed/NCBI View Article : Google Scholar

16 

Rafiq S, Hackett CS and Brentjens RJ: Engineering strategies to overcome the current roadblocks in CAR T cell therapy. Nat Rev Clin Oncol. 17:147–167. 2020.PubMed/NCBI View Article : Google Scholar

17 

Finck AV, Blanchard T, Roselle CP, Golinelli G and June CH: Engineered cellular immunotherapies in cancer and beyond. Nat Med. 28:678–689. 2022.PubMed/NCBI View Article : Google Scholar

18 

Jensen MC and Riddell SR: Designing chimeric antigen receptors to effectively and safely target tumors. Curr Opin Immunol. 33:9–15. 2015.PubMed/NCBI View Article : Google Scholar

19 

Brocker T and Karjalainen K: Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med. 181:1653–1659. 1995.PubMed/NCBI View Article : Google Scholar

20 

Frauwirth KA and Thompson CB: Activation and inhibition of lymphocytes by costimulation. J Clin Invest. 109:295–299. 2002.PubMed/NCBI View Article : Google Scholar

21 

Kagoya Y, Tanaka S, Guo T, Anczurowski M, Wang CH, Saso K, Butler MO, Minden MD and Hirano N: A novel chimeric antigen receptor containing a JAK-STAT signaling domain mediates superior antitumor effects. Nat Med. 24:352–359. 2018.PubMed/NCBI View Article : Google Scholar

22 

Jan M, Scarfo I, Larson RC, Walker A, Schmidts A, Guirguis AA, Gasser JA, Słabicki M, Bouffard AA, Castano AP, et al: Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide. Sci Transl Med. 13(eabb6295)2021.PubMed/NCBI View Article : Google Scholar

23 

Aspuria PJ, Vivona S, Bauer M, Semana M, Ratti N, McCauley S, Riener R, de Waal Malefyt R, Rokkam D, Emmerich J, et al: An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma. Sci Transl Med. 13(eabg7565)2021.PubMed/NCBI View Article : Google Scholar

24 

Shirasu N and Kuroki M: Functional design of chimeric T-cell antigen receptors for adoptive immunotherapy of cancer: Architecture and outcomes. Anticancer Res. 32:2377–2383. 2012.PubMed/NCBI

25 

Gattinoni L, Finkelstein SE, Klebanoff CA, Antony PA, Palmer DC, Spiess PJ, Hwang LN, Yu Z, Wrzesinski C, Heimann DM, et al: Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med. 202:907–912. 2005.PubMed/NCBI View Article : Google Scholar

26 

Majzner RG and Mackall CL: Tumor Antigen Escape from CAR T-cell Therapy. Cancer Discov. 8:1219–1226. 2018.PubMed/NCBI View Article : Google Scholar

27 

Maude SL, Teachey DT, Porter DL and Grupp SA: CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Blood. 125:4017–4023. 2015.PubMed/NCBI View Article : Google Scholar

28 

Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, et al: T cells genetically modified to express an Anti-B-Cell maturation antigen chimeric antigen receptor cause remissions of poor-prognosis relapsed multiple myeloma. J Clin Oncol. 36:2267–2280. 2018.PubMed/NCBI View Article : Google Scholar

29 

Cohen AD, Garfall AL, Stadtmauer EA, Melenhorst JJ, Lacey SF, Lancaster E, Vogl DT, Weiss BM, Dengel K, Nelson A, et al: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. J Clin Invest. 129:2210–2221. 2019.PubMed/NCBI View Article : Google Scholar

30 

Brown CE, Alizadeh D, Starr R, Weng L, Wagner JR, Naranjo A, Ostberg JR, Blanchard MS, Kilpatrick J, Simpson J, et al: Regression of glioblastoma after chimeric antigen receptor T-Cell therapy. N Engl J Med. 375:2561–2569. 2016.PubMed/NCBI View Article : Google Scholar

31 

Poondla N, Sheykhhasan M, Akbari M, Samadi P, Kalhor N and Manoochehri H: The Promise of CAR T-Cell therapy for the treatment of cancer stem cells: A short review. Curr Stem Cell Res Ther. 17:400–406. 2022.PubMed/NCBI View Article : Google Scholar

32 

Yan Z, Cao J, Cheng H, Qiao J, Zhang H, Wang Y, Shi M, Lan J, Fei X, Jin L, et al: A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed or refractory multiple myeloma: A single-arm, phase 2 trial. Lancet Haematol. 6:e521–e529. 2019.PubMed/NCBI View Article : Google Scholar

33 

Dai H, Wu Z, Jia H, Tong C, Guo Y, Ti D, Han X, Liu Y, Zhang W, Wang C, et al: Bispecific CAR T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia. J Hematol Oncol. 13(30)2020.PubMed/NCBI View Article : Google Scholar

34 

Zeng W, Zhang Q, Zhu Y, Ou R, Peng L, Wang B, Shen H, Liu Z, Lu L, Zhang P and Liu S: Engineering Novel CD19/CD22 Dual-Target CAR T cells for improved anti-tumor activity. Cancer Invest. 40:282–292. 2022.PubMed/NCBI View Article : Google Scholar

35 

Cordoba S, Onuoha S, Thomas S, Pignataro DS, Hough R, Ghorashian S, Vora A, Bonney D, Veys P, Rao K, et al: CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: A phase 1 trial. Nat Med. 27:1797–1805. 2021.PubMed/NCBI View Article : Google Scholar

36 

Sterner RC and Sterner RM: CAR T cell therapy: Current limitations and potential strategies. Blood Cancer J. 11(69)2021.PubMed/NCBI View Article : Google Scholar

37 

Wilkie S, van Schalkwyk MC, Hobbs S, Davies DM, van der Stegen SJ, Pereira AC, Burbridge SE, Box C, Eccles SA and Maher J: Dual targeting of ErbB2 and MUC1 in breast cancer using chimeric antigen receptors engineered to provide complementary signaling. J Clin Immunol. 32:1059–1070. 2012.PubMed/NCBI View Article : Google Scholar

38 

Kong Y, Tang L, You Y, Li Q and Zhu X: Analysis of causes for poor persistence of CAR T cell therapy in vivo. Front Immunol. 14(1063454)2023.PubMed/NCBI View Article : Google Scholar

39 

Al-Haideri M, Tondok SB, Safa SH, Maleki AH, Rostami S, Jalil AT, Al-Gazally ME, Alsaikhan F, Rizaev JA, Mohammad TAM and Tahmasebi S: CAR T cell combination therapy: The next revolution in cancer treatment. Cancer Cell Int. 22(365)2022.PubMed/NCBI View Article : Google Scholar

40 

Mohammadi M, Akhoundi M, Malih S, Mohammadi A and Sheykhhasan M: Therapeutic roles of CAR T cells in infectious diseases: Clinical lessons learnt from cancer. Rev Med Virol. 32(e2325)2022.PubMed/NCBI View Article : Google Scholar

41 

Di Stasi A, Tey SK, Dotti G, Fujita Y, Kennedy-Nasser A, Martinez C, Straathof K, Liu E, Durett AG, Grilley B, et al: Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med. 365:1673–1683. 2011.PubMed/NCBI View Article : Google Scholar

42 

Juillerat A, Tkach D, Busser BW, Temburni S, Valton J, Duclert A, Poirot L, Depil S and Duchateau P: Modulation of chimeric antigen receptor surface expression by a small molecule switch. BMC Biotechnol. 19(44)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Poojary R, Song AF, Song BS, Song CS, Wang L and Song J: Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Mol Clin Oncol 19: 95, 2023.
APA
Poojary, R., Song, A.F., Song, B.S., Song, C.S., Wang, L., & Song, J. (2023). Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Molecular and Clinical Oncology, 19, 95. https://doi.org/10.3892/mco.2023.2691
MLA
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19.6 (2023): 95.
Chicago
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19, no. 6 (2023): 95. https://doi.org/10.3892/mco.2023.2691
Copy and paste a formatted citation
x
Spandidos Publications style
Poojary R, Song AF, Song BS, Song CS, Wang L and Song J: Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Mol Clin Oncol 19: 95, 2023.
APA
Poojary, R., Song, A.F., Song, B.S., Song, C.S., Wang, L., & Song, J. (2023). Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review). Molecular and Clinical Oncology, 19, 95. https://doi.org/10.3892/mco.2023.2691
MLA
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19.6 (2023): 95.
Chicago
Poojary, R., Song, A. F., Song, B. S., Song, C. S., Wang, L., Song, J."Investigating chimeric antigen receptor T cell therapy and the potential for cancer immunotherapy (Review)". Molecular and Clinical Oncology 19, no. 6 (2023): 95. https://doi.org/10.3892/mco.2023.2691
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