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Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction

  • Authors:
    • Georg Hoene
    • Norman Moser
    • Boris Schminke
    • Bernhard Wiechens
    • Andreas Leha
    • Tatjana Khromov
    • Henning Schliephake
    • Phillipp Brockmeyer
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, University Medical Center Goettingen, D‑37075 Goettingen, Germany, Department of Orthodontics, University Medical Center Goettingen, D‑37075 Goettingen, Germany, Institute of Medical Statistics, University Medical Center Goettingen, D‑37073 Goettingen, Germany, Institute of Clinical Chemistry, University Medical Center Goettingen, D‑37075 Goettingen, Germany
    Copyright: © Hoene et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 97
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    Published online on: October 19, 2023
       https://doi.org/10.3892/mco.2023.2693
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Abstract

The present study aimed to assess the concordance of preoperative and postoperative hard and soft tissues in patients with advanced oral squamous cell carcinoma (OSCC) following virtual surgical planning (VSP) mandibular reconstruction. In the present study, a cohort of 32 patients with OSCC underwent in‑house VSP, followed by guided mandibular reconstruction utilizing vascularized free tissue grafts sourced from the fibula or scapula. A morphometric analysis was conducted comparing preoperative and postoperative three‑dimensional virtual models to evaluate discrepancies and identify potential risk factors associated with poor reconstruction outcomes. The outcome variables were the differences in root mean square (RMS) and mean surface distance (MSD) resulting from the application of an iterative closest point algorithm to the virtual data. The validity of soft tissue comparison data is limited due to its susceptibility to various confounding variables. The present study conducted a comprehensive re‑evaluation of these variables. High tumor stage, positive N status and the use of adjuvant therapy contributed to more noticeable differences in preoperative and postoperative facial soft tissue appearance. The accuracy of postoperative bone reconstruction results was higher in patients who underwent neomandibular formation using a fibular graft compared with those who received a scapular graft. Preoperative and postoperative soft tissue analyses were conducted for comparison. The MSD showed a deviation of 3.2 mm (± 2.0 mm SD; range 1.3‑9.5 mm), whereas the RMS was 5.3 (± 2.9 SD; range 2.1‑14). In conclusion, in‑house VSP and guided mandibular reconstructions can yield clinically accurate results, preserving patient appearance and offering the advantage of rapid feasibility.
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Copy and paste a formatted citation
Spandidos Publications style
Hoene G, Moser N, Schminke B, Wiechens B, Leha A, Khromov T, Schliephake H and Brockmeyer P: Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction. Mol Clin Oncol 19: 97, 2023.
APA
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T. ... Brockmeyer, P. (2023). Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction. Molecular and Clinical Oncology, 19, 97. https://doi.org/10.3892/mco.2023.2693
MLA
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T., Schliephake, H., Brockmeyer, P."Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction". Molecular and Clinical Oncology 19.6 (2023): 97.
Chicago
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T., Schliephake, H., Brockmeyer, P."Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction". Molecular and Clinical Oncology 19, no. 6 (2023): 97. https://doi.org/10.3892/mco.2023.2693
Copy and paste a formatted citation
x
Spandidos Publications style
Hoene G, Moser N, Schminke B, Wiechens B, Leha A, Khromov T, Schliephake H and Brockmeyer P: Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction. Mol Clin Oncol 19: 97, 2023.
APA
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T. ... Brockmeyer, P. (2023). Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction. Molecular and Clinical Oncology, 19, 97. https://doi.org/10.3892/mco.2023.2693
MLA
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T., Schliephake, H., Brockmeyer, P."Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction". Molecular and Clinical Oncology 19.6 (2023): 97.
Chicago
Hoene, G., Moser, N., Schminke, B., Wiechens, B., Leha, A., Khromov, T., Schliephake, H., Brockmeyer, P."Postoperative facial appearance of patients with extensive oral squamous cell carcinoma can be adequately preserved with in‑house virtually planned mandibular reconstruction". Molecular and Clinical Oncology 19, no. 6 (2023): 97. https://doi.org/10.3892/mco.2023.2693
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