Pan‑cancer analysis identified ARHGAP23 as a potential biomarker for pancreatic adenocarcinoma

Liu,Xiaolong; Li,Xin; Wang,Ling; Yu,Kaihua; Wu,Dean; Tao,Pengxian; Li,Yulan

doi:10.3892/mco.2023.2696

December-2023 Volume 19 Issue 6

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December-2023 Volume 19 Issue 6

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Pan‑cancer analysis identified ARHGAP23 as a potential biomarker for pancreatic adenocarcinoma

Authors:
- Xiaolong Liu
- Xin Li
- Ling Wang
- Kaihua Yu
- Dean Wu
- Pengxian Tao
- Yulan Li
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Affiliations: The First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, The General Surgery Department, Lanzhou University Second Hospital, Lanzhou, Gansu 730000, P.R. China, Department of Pathology, Lanzhou, Gansu 730000, P.R. China, Cadre Ward of General Surgery Department, Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China

Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 100
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Published online on: November 3, 2023

https://doi.org/10.3892/mco.2023.2696
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Abstract

Rho GTPASE‑activating protein 23 (ARHGAP23) is known to activate RHO‑GTPase and has an important role in the infiltration and metastasis of tumors. Although previous studies suggested its involvement in certain human cancers, its role in pan‑cancer remains unclear. In the present study, the expression, prognosis and potential functions of ARHGAP23 in pan‑cancer were evaluated through various public databases such as Human Protein Atlas, Tumor IMmune Estimation Resource, Gene Set Co‑Expression Analysis, Gene Expression Profiling Interactive Analysis, cBio Cancer Genomics Portal, Tumor‑Immune System Interactions Database (TISIDB) and others. Through these data combined with a variety of biological information analysis methods, the potential role of ARHGAP23 as a carcinogenic gene was explored in the present study. The present analysis revealed that ARHGAP23 expressed abnormalities in >10 tumors, which was associated with differences in prognosis. Furthermore, the findings of the present study indicated that ARHGAP23 is associated with DNA methylation and multiple immune cell infiltrations in these tumors. ARHGAP23 expression was related to clinical prognosis, DNA methylation and immune infiltration. These findings support the potential of ARHGAP23 as a prognostic biomarker and a molecular target for cancer treatment.

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1	Cao W, Chen HD, Yu YW, Li N and Chen WQ: Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 134:783–791. 2021.PubMed/NCBI View Article : Google Scholar
2	Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020.PubMed/NCBI View Article : Google Scholar
3	Katoh M and Katoh M: Identification and characterization of human ARHGAP23 gene in silico. Int J Oncol. 25:535–540. 2004.PubMed/NCBI
4	Hodge RG and Ridley AJ: Regulating Rho GTPases and their regulators. Nat Rev Mol Cell Biol. 17:496–510. 2016.PubMed/NCBI View Article : Google Scholar
5	Heasman SJ and Ridley AJ: Mammalian Rho GTPases: New insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 9:690–701. 2008.PubMed/NCBI View Article : Google Scholar
6	Vega FM and Ridley AJ: Rho GTPases in cancer cell biology. FEBS Lett. 582:2093–2101. 2008.PubMed/NCBI View Article : Google Scholar
7	Cardama GA, Gonzalez N, Maggio J, Menna PL and Gomez DE: Rho GTPases as therapeutic targets in cancer (Review). Int J Oncol. 51:1025–1034. 2017.PubMed/NCBI View Article : Google Scholar
8	Schroeder MP, Gonzalez-Perez A and Lopez-Bigas N: Visualizing multidimensional cancer genomics data. Genome Med. 5(9)2013.PubMed/NCBI View Article : Google Scholar
9	Kustatscher G, Grabowski P, Schrader TA, Passmore JB, Schrader M and Rappsilber J: Co-regulation map of the human proteome enables identification of protein functions. Nat Biotechnol. 37:1361–1371. 2019.PubMed/NCBI View Article : Google Scholar
10	Liu Y, Yasukawa M, Chen K, Hu L, Broaddus RR, Ding L, Mardis ER, Spellman P, Levine DA, Mills GB, et al: Association of Somatic Mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma. JAMA Oncol. 1:486–494. 2015.PubMed/NCBI View Article : Google Scholar
11	Rong G, Yi Z, Ma F, Guan Y, Xu Y, Li L and Xu B: DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis. Ann Transl Med. 9(220)2021.PubMed/NCBI View Article : Google Scholar
12	Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, et al: Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell. 176:98–112.e14. 2019.PubMed/NCBI View Article : Google Scholar
13	Pan Y, Liu G, Zhou F, Su B and Li Y: DNA methylation profiles in cancer diagnosis and therapeutics. Clin Exp Med. 18:1–14. 2018.PubMed/NCBI View Article : Google Scholar
14	Picard E, Verschoor CP, Ma GW and Pawelec G: Relationships between immune landscapes, genetic subtypes and responses to immunotherapy in colorectal cancer. Front Immunol. 11(369)2020.PubMed/NCBI View Article : Google Scholar
15	Nurmik M, Ullmann P, Rodriguez F, Haan S and Letellier E: In search of definitions: Cancer-associated fibroblasts and their markers. Int J Cancer. 146:895–905. 2020.PubMed/NCBI View Article : Google Scholar
16	Galbo PM Jr, Zang X and Zheng D: Molecular features of cancer-associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance. Clin Cancer Res. 27:2636–2647. 2021.PubMed/NCBI View Article : Google Scholar
17	Costa A, Kieffer Y, Scholer-Dahirel A, Pelon F, Bourachot B, Cardon M, Sirven P, Magagna I, Fuhrmann L, Bernard C, et al: Fibroblast heterogeneity and immunosuppressive environment in human breast cancer. Cancer Cell. 33:463–479.e10. 2018.PubMed/NCBI View Article : Google Scholar
18	An Y, Liu F, Chen Y and Yang Q: Crosstalk between cancer-associated fibroblasts and immune cells in cancer. J Cell Mol Med. 24:13–24. 2020.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pan‑cancer analysis identified ARHGAP23 as a potential biomarker for pancreatic adenocarcinoma

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