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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2023 Volume 19 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary

  • Authors:
    • Larissa Lee White
    • Julie Smith‑Gagen
    • Leslie Elliott
    • Minggen Lu
  • View Affiliations / Copyright

    Affiliations: Kaiser Permanente Colorado, Institute for Health Research, Aurora, CO 80014, USA, School of Public Health, University of Nevada, Reno, NV 89557, USA
  • Article Number: 101
    |
    Published online on: November 6, 2023
       https://doi.org/10.3892/mco.2023.2697
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Abstract

Cancer of unknown primary (CUP) and pancreatic cancer (PC) are malignancies associated with poor prognosis. CUP is the fourth most common cause of cancer mortality in the US, and median survival time is 3‑4 months. PC is the third most common cause of cancer mortality in the US, and median survival time for patients with stage 3 or 4 PC is 2‑3 months. The present study aimed to understand the patient characteristics of those initially misdiagnosed with CUP who ultimately received a diagnosis of PC. The present study used 2010‑2015 Surveillance, Epidemiology, and End Results‑Medicare data, a US population‑based cancer registry linked to Medicare health insurance claims. Odds ratios (ORs) and 95% confidence intervals were calculated using two binary logistic regression models to compare the characteristics of patients who received definitive diagnosis between the CUP‑PC group (those with an initial diagnosis of CUP who eventually received a stage 3 or 4 PC diagnosis) and the PC group (those diagnosed with stage 3 or 4 PC only). Approximately 26% of patients who received a definitive diagnosis of metastatic PC started with an initial diagnosis of CUP (n=17,565). The odds of definitive PC diagnosis in patients with CUP were lower for those with a comorbidity score of 0 [OR, 0.85 (95% CI: 0.79, 0.91)] and epithelial/unspecified histology [OR, 0.76 (95% CI: 0.71, 0.82)]. The odds of definitive PC diagnosis in patients with CUP were higher for patients of other race [OR, 1.27 (95% CI: 1.13, 1.43)] compared with white patients. Definitive diagnosis of PC in patients with CUP was lower in patients who were older with fewer or no comorbidities and unspecified histology. The complexity of CUP diagnosis and patient performance status may influence delays in diagnosis to a known primary site.
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Copy and paste a formatted citation
Spandidos Publications style
White LL, Smith‑Gagen J, Elliott L and Lu M: Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary. Mol Clin Oncol 19: 101, 2023.
APA
White, L.L., Smith‑Gagen, J., Elliott, L., & Lu, M. (2023). Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary. Molecular and Clinical Oncology, 19, 101. https://doi.org/10.3892/mco.2023.2697
MLA
White, L. L., Smith‑Gagen, J., Elliott, L., Lu, M."Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary". Molecular and Clinical Oncology 19.6 (2023): 101.
Chicago
White, L. L., Smith‑Gagen, J., Elliott, L., Lu, M."Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary". Molecular and Clinical Oncology 19, no. 6 (2023): 101. https://doi.org/10.3892/mco.2023.2697
Copy and paste a formatted citation
x
Spandidos Publications style
White LL, Smith‑Gagen J, Elliott L and Lu M: Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary. Mol Clin Oncol 19: 101, 2023.
APA
White, L.L., Smith‑Gagen, J., Elliott, L., & Lu, M. (2023). Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary. Molecular and Clinical Oncology, 19, 101. https://doi.org/10.3892/mco.2023.2697
MLA
White, L. L., Smith‑Gagen, J., Elliott, L., Lu, M."Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary". Molecular and Clinical Oncology 19.6 (2023): 101.
Chicago
White, L. L., Smith‑Gagen, J., Elliott, L., Lu, M."Patient characteristics associated with definitive diagnosis of metastatic pancreatic cancer in those initially diagnosed with cancer of unknown primary". Molecular and Clinical Oncology 19, no. 6 (2023): 101. https://doi.org/10.3892/mco.2023.2697
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