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Progress in the research of immunotherapy‑related hyperprogression (Review)

  • Authors:
    • Ruizhe Qi
    • Lihui Yang
    • Xinchao Zhao
    • Liying Huo
    • Yaling Wang
    • Peifang Zhang
    • Xiaomei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei 054000, P.R. China, Department of Nursing, The Second Affiliated Hospital of Xingtai Medical College, Xingtai, Hebei 054000, P.R. China, Department of Pharmacy, Zhengzhou Ninth People's Hospital, Zhengzhou, Henan 450000, P.R. China, Department of Pharmacy, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong 518102, P.R. China
  • Article Number: 3
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    Published online on: November 17, 2023
       https://doi.org/10.3892/mco.2023.2701
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Abstract

Immunotherapy has become an effective method for the treatment of a variety of malignant tumors. However, with the development of immunotherapy, the phenomenon of hyperprogression in patients with cancer has gradually attracted attention. Hyperprogression refers to a condition in which the progression of a disease during treatment of a patient with cancer is suddenly accelerated. To date, no reliable marker has been found to predict accelerated tumor growth during immune checkpoint inhibitor (ICI) treatment. The aim the present study was to summarize the definition of hyperprogression and the difference between hyperprogression and pseudocytosis, and investigate the potential mechanisms of hyperprogression including clinical characteristics, potential molecular markers and the immune microenvironment. The effect of macrophage‑related different types and factors on tumors in the immune microenvironment was analyzed, and the findings may be used to determine the future directions of research in hyperprogression.
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Spandidos Publications style
Qi R, Yang L, Zhao X, Huo L, Wang Y, Zhang P and Chen X: Progress in the research of immunotherapy‑related hyperprogression (Review). Mol Clin Oncol 20: 3, 2024.
APA
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., & Chen, X. (2024). Progress in the research of immunotherapy‑related hyperprogression (Review). Molecular and Clinical Oncology, 20, 3. https://doi.org/10.3892/mco.2023.2701
MLA
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., Chen, X."Progress in the research of immunotherapy‑related hyperprogression (Review)". Molecular and Clinical Oncology 20.1 (2024): 3.
Chicago
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., Chen, X."Progress in the research of immunotherapy‑related hyperprogression (Review)". Molecular and Clinical Oncology 20, no. 1 (2024): 3. https://doi.org/10.3892/mco.2023.2701
Copy and paste a formatted citation
x
Spandidos Publications style
Qi R, Yang L, Zhao X, Huo L, Wang Y, Zhang P and Chen X: Progress in the research of immunotherapy‑related hyperprogression (Review). Mol Clin Oncol 20: 3, 2024.
APA
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., & Chen, X. (2024). Progress in the research of immunotherapy‑related hyperprogression (Review). Molecular and Clinical Oncology, 20, 3. https://doi.org/10.3892/mco.2023.2701
MLA
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., Chen, X."Progress in the research of immunotherapy‑related hyperprogression (Review)". Molecular and Clinical Oncology 20.1 (2024): 3.
Chicago
Qi, R., Yang, L., Zhao, X., Huo, L., Wang, Y., Zhang, P., Chen, X."Progress in the research of immunotherapy‑related hyperprogression (Review)". Molecular and Clinical Oncology 20, no. 1 (2024): 3. https://doi.org/10.3892/mco.2023.2701
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