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Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review

  • Authors:
    • Hui Guo
    • Xue-Ying Lin
    • Shuai Feng
    • Cong Wang
    • Ling-Qin Yuan
    • Xiu-Gui Sheng
    • Da-Peng Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China, Department of Surgery, Liaocheng Dongchangfu District Maternal and Child Health Hospital, Liaocheng, Shandong 252019, P.R. China, Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
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    Published online on: November 21, 2023
       https://doi.org/10.3892/mco.2023.2703
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Abstract

Accumulating interest has been surging over the past few years regarding the effects of obesity on immunotherapy. In addition to the body mass index (BMI), imaging‑quantified body fat compartments have been investigated. The present study aimed to evaluate the predictive value of the BMI and computed tomography (CT)‑based body fat in patients with cancer receiving immunotherapy. For this purpose, the PubMed, MEDLINE, EMBASE and Cochrane databases were searched from January 2017 to July 2022. Clinical studies evaluating the association between BMI or body fat and survival of patients with cancer treated with immune checkpoint inhibitors (ICIs) were included. In total, 15 studies reporting on the BMI were included in the meta‑analysis and 16 studies evaluating body fat were included in the systematic review. According to the classification of the World Health Organization, overweight and obese patients with ICI treatment showed improved overall survival [overweight vs. normal: Hazard ratio (HR)=0.79, 95% confidence interval (CI)=0.64‑0.98, P=0.03; obese vs. normal: HR=0.75, 95% CI=0.60‑0.94, P=0.013] and progression‑free survival (overweight vs. normal: HR=0.82, 95% CI=0.70‑0.97, P=0.02; obese vs. normal: HR=0.81, 95% CI=0.65‑1.02, P=0.07). Among the articles investigating the effect of body fat composition on the efficacy of immunotherapy, a number of studies included various CT analysis techniques and cutoffs to define body fat composition. Associations of body fat with survival were contradictory in different patients with cancer treated with immunotherapy. Obesity was associated with better survival in patients with cancer treated with ICIs. Further analyses are required to demonstrate the prognostic value of body fat in patients with cancer immunotherapy.
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Spandidos Publications style
Guo H, Lin X, Feng S, Wang C, Yuan L, Sheng X and Li D: Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review. Mol Clin Oncol 20: 5, 2024.
APA
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., & Li, D. (2024). Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review. Molecular and Clinical Oncology, 20, 5. https://doi.org/10.3892/mco.2023.2703
MLA
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., Li, D."Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review". Molecular and Clinical Oncology 20.1 (2024): 5.
Chicago
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., Li, D."Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review". Molecular and Clinical Oncology 20, no. 1 (2024): 5. https://doi.org/10.3892/mco.2023.2703
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Spandidos Publications style
Guo H, Lin X, Feng S, Wang C, Yuan L, Sheng X and Li D: Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review. Mol Clin Oncol 20: 5, 2024.
APA
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., & Li, D. (2024). Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review. Molecular and Clinical Oncology, 20, 5. https://doi.org/10.3892/mco.2023.2703
MLA
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., Li, D."Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review". Molecular and Clinical Oncology 20.1 (2024): 5.
Chicago
Guo, H., Lin, X., Feng, S., Wang, C., Yuan, L., Sheng, X., Li, D."Prognostic value of obesity in patients with cancer treated with immune checkpoint inhibitors: An updated meta‑analysis and systematic review". Molecular and Clinical Oncology 20, no. 1 (2024): 5. https://doi.org/10.3892/mco.2023.2703
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