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Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin

  • Authors:
    • Xian Li
    • Jiaqi Peng
    • Xiulan Su
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    Affiliations: Key Laboratory of Medical Cell Biology in Inner Mongolia, Inner Mongolia Bioactive Peptide Engineering Laboratory, Clinical Medical Research Center, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 9
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    Published online on: December 6, 2023
       https://doi.org/10.3892/mco.2023.2707
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Abstract

Gastric cancer is one of the most common malignant tumors of the digestive system. An anticancer bioactive peptide (ACBP) was previously shown to have an important role in inhibiting the differentiation of the MKN‑45, N87 and GES‑1 cell lines. However, to date, research on the effects of inflammatory factors in MKN‑45, N87 and GES‑1 cell lines after treatment with ACBP combined with oxaliplatin (OXA) has not been performed. To investigate the expression of immune regulatory factors, tumor growth factors and chemotactic factors in differentiated gastric cancer cells treated with ACBP combined with OXA, the expression of cytokines, including interleukin (IL)‑1β, IL‑1 receptor antagonist, IL‑2, IL‑4, IL‑6‑10, IL‑12, IL‑13, IL‑15, IL‑17, Eotaxin, basic fibroblast growth factor (bFGF), granulocyte‑macrophage colony‑stimulating factor (GM‑CSF), interferon (IFN)‑γ, monocyte chemoattractant protein (MCP)‑1, IFN‑γ‑induced protein‑10, macrophage inflammatory protein (MIP)‑1α, platelet‑derived growth factor (PDGF)‑BB, MIP‑1β, regulated upon activation, normal T cell expressed and presumably secreted, TNF‑α and VEGF, was assessed with cell experiments using the Bio‑Plex ProT Human Cytokine 27‑plex Assay. The results indicated that immune regulatory factor, tumor growth factor and chemotactic factor expression levels were different after treatment with ACBP alone or ACBP combined with OXA. IFN‑γ, IL‑1β, IL‑17, IL‑9, IL‑10, IL‑15, bFGF, GM‑CSF and PDGF‑BB expression was decreased in MKN‑45 and N87 cells after ACBP treatment (P<0.01) and ACBP+OXA treatment (P<0.01) compared with the control cells, which indicated that ACBP inhibited tumor growth by regulating these cytokines, and the combination treatment inhibited tumor growth by regulating these cytokines. MIP‑1β, MCP‑1 and IL‑13 expression was decreased in MKN‑45 and N87 cells after the combination treatment compared with ACBP treatment alone, which indicated that ACBP combined with OXA was able to inhibit tumor growth by regulating these cytokines, while the mechanism of action of the ACBP and OXA is actually different, e.g. for OXA, this would be to cause DNA damage response. Therefore, the ACBP and OXA combination treatment may be closely associated with tumor progression and metastasis with immunological competence by MCP‑1, MIP‑1β and IL‑13 expression.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010.PubMed/NCBI View Article : Google Scholar

2 

Yang K, Chen XZ and Hu JK: Factors associated with recurrence and survival in N0 gastric cancer. Ann Surg. 266:e10–e11. 2017.PubMed/NCBI View Article : Google Scholar

3 

Zhang F, Yan Y, Cao X, Zhang J, Li Y and Guo C: Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer. Aging (Albany NY). 13:12224–12238. 2021.PubMed/NCBI View Article : Google Scholar

4 

Billones R, Liwang JK, Butler K, Graves L and Saligan LN: Dissecting the fatigue experience: A scoping review of fatigue definitions, dimensions, and measures in non-oncologic medical conditions. Brain Behav Immun Health. 15(100266)2021.PubMed/NCBI View Article : Google Scholar

5 

Tian J and Hong JS: Validation of the Chinese version of multidimensional fatigue Inventory-20 in Chinese patients with cancer. Support Care Cancer. 20:2379–2383. 2012.PubMed/NCBI View Article : Google Scholar

6 

Li X, Xia L, Ouyang X, Suyila Q, Su L and Su X: Bioactive peptides sensitize cells to anticancer effects of oxaliplatin in human colorectal cancer xenografts in nude mice. Protein Pept Lett. 26:512–522. 2019.PubMed/NCBI View Article : Google Scholar

7 

Su X, Dong C, Zhang J, Su L, Wang X, Cui H and Chen Z: Combination therapy of anti-cancer bioactive peptide with Cisplatin decreases chemotherapy dosing and toxicity to improve the quality of life in xenograft nude mice bearing human gastric cancer. Cell Biosci. 4(7)2014.PubMed/NCBI View Article : Google Scholar

8 

Li X, Gao B and Su X: Anticancer bioactive peptide combined with docetaxel and its mechanism in the treatment of breast cancer. Exp Ther Med. 20:1917–1924. 2020.PubMed/NCBI View Article : Google Scholar

9 

Li X, Wu H, Ouyang X, Zhang B and Su X: New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity. Oncol Rep. 38:129–140. 2017.PubMed/NCBI View Article : Google Scholar

10 

Wang X, Guo J, Wang Y, Xiao Y, Wang L and Hua S: Expression levels of interferon regulatory factor 5 (IRF5) and related inflammatory cytokines associated with severity, prognosis, and causative pathogen in patients with community-acquired pneumonia. Med Sci Monit. 24:3620–3630. 2018.PubMed/NCBI View Article : Google Scholar

11 

Garlanda C, Dinarello CA and Mantovani A: The interleukin-1 family: Back to the future. Immunity. 39:1003–1018. 2013.PubMed/NCBI View Article : Google Scholar

12 

Gao LB, Pan XM, Jia J, Liang WB, Rao L, Xue H, Zhu Y, Li SL, Lv ML, Deng W, et al: IL-8-251A/T polymorphism is associated with decreased cancer risk among population-based studies: Evidence from a meta-analysis. Eur J Cancer. 46:1333–1343. 2010.PubMed/NCBI View Article : Google Scholar

13 

Patidar M, Yadav N and Dalai SK: Interleukin 15: A key cytokine for immunotherapy. Cytokine Growth Factor Rev. 31:49–59. 2016.PubMed/NCBI View Article : Google Scholar

14 

Abusleme L and Moutsopoulos NM: IL-17: Overview and role in oral immunity and microbiome. Oral Dis. 23:854–865. 2017.PubMed/NCBI View Article : Google Scholar

15 

Chen S, Shen Z, Liu Z, Gao L, Han Z, Yu S and Kang M: IL-1RA suppresses esophageal cancer cell growth by blocking IL-1α. J Clin Lab Anal. 33(e22903)2019.PubMed/NCBI View Article : Google Scholar

16 

Zheng N and Lu Y: Targeting the IL-9 pathway in cancer immunotherapy. Hum Vaccin Immunother. 16:2333–2340. 2020.PubMed/NCBI View Article : Google Scholar

17 

Kalayci M and Gul E: Eotaxin-1 levels in patients with myocardial infarction. Clin Lab: 68, 2022 doi: 10.7754/Clin.Lab.2021.210806.

18 

Pereiro P, Figueras A and Novoa B: Insights into teleost interferon-gamma biology: An update. Fish Shellfish Immunol. 90:150–164. 2019.PubMed/NCBI View Article : Google Scholar

19 

Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL and Mihu CM: Vascular endothelial growth factor (VEGF)-key factor in normal and pathological angiogenesis. Rom J Morphol Embryol. 59:455–467. 2018.PubMed/NCBI

20 

Gao SY, Lin RB, Huang SH, Liang YJ, Li X, Zhang SE, Ouyang DQ, Li K, Zheng GS and Liao GQ: PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis. Bone. 44(115117)2021.PubMed/NCBI View Article : Google Scholar

21 

Khajvand T, Huang P, Li L, Zhang M, Zhu F, Xu X, Huang M, Yang C, Lu Y and Zhu Z: Interfacing droplet microfluidics with antibody barcodes for multiplexed single-cell protein secretion profiling. Lab Chip. 21:4823–4830. 2021.PubMed/NCBI View Article : Google Scholar

22 

Qian Y, He Z, Zhao SS, Liu B, Chen Y, Sun X, Ye D, Jiang X, Zheng H, Wen C, et al: Genetically determined circulating levels of cytokines and the risk of rheumatoid arthritis. Front Genet. 13(802464)2022.PubMed/NCBI View Article : Google Scholar

23 

Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, et al: Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agents. 24:1–6. 2010.PubMed/NCBI

24 

Ntanasis-Stathopoulos I, Fotiou D and Terpos E: CCL3 signaling in the tumor microenvironment. Adv Exp Med Biol. 1231:13–21. 2020.PubMed/NCBI View Article : Google Scholar

25 

Jiang Y, Huang F, Chai X, Yuan W, Ding H and Wu X: The role of IP-10 and its receptor CXCR3 in early pregnancy. Mol Immunol. 140:59–69. 2021.PubMed/NCBI View Article : Google Scholar

26 

Becher B, Tugues S and Greter M: GM-CSF: From growth factor to central mediator of tissue inflammation. Immunity. 45:963–973. 2016.PubMed/NCBI View Article : Google Scholar

27 

Kanda T, Yoshida A, Ogihara K, Minami H, Yamaguchi N, Ikebuchi Y, Nakao K and Isomoto H: Detection of cytokine storm in patients with achalasia using ELISA. Biomed Rep. 15(62)2021.PubMed/NCBI View Article : Google Scholar

28 

Bernstein JM, Ballow M, Xiang S and O'Neil K: Th1/Th2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media. Ann Otol Rhinol Laryngol. 107:22–27. 1998.PubMed/NCBI View Article : Google Scholar

29 

Abbas AK, Trotta E, R Simeonov D, Marson A and Bluestone JA: Revisiting IL-2: Biology and therapeutic prospects. Sci Immunol. 3(eaat1482)2018.PubMed/NCBI View Article : Google Scholar

30 

Iwaszko M, Biały S and Bogunia-Kubik K: Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis. Cells. 10(3000)2021.PubMed/NCBI View Article : Google Scholar

31 

Tanaka T, Narazaki M and Kishimoto T: Interleukin (IL-6) immunotherapy. Cold Spring Harb Perspect Biol. 10(a028456)2018.PubMed/NCBI View Article : Google Scholar

32 

Yan B, Wei JJ, Yuan Y, Sun R, Li D, Luo J, Liao SJ, Zhou YH, Shu Y, Wang Q, et al: IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation. J Immunol. 190:5882–5893. 2013.PubMed/NCBI View Article : Google Scholar

33 

Yaseen MM, Abuharfeil NM, Darmani H and Daoud A: Mechanisms of immune suppression by myeloid-derived suppressor cells: The role of interleukin-10 as a key immunoregulatory cytokine. Open Biol. 10(200111)2020.PubMed/NCBI View Article : Google Scholar

34 

Saraiva M, Vieira P and O'Garra A: Biology and therapeutic potential of interleukin-10. J Exp Med. 217(e20190418)2020.PubMed/NCBI View Article : Google Scholar

35 

Wang C, Kong L, Kim S, Lee S, Oh S, Jo S, Jang I and Kim TD: The Role of IL-7 and IL-7R in cancer pathophysiology and immunotherapy. Int J Mol Sci. 23(10412)2022.PubMed/NCBI View Article : Google Scholar

36 

Nguyen KG, Vrabel MR, Mantooth SM, Hopkins JJ, Wagner ES, Gabaldon TA and Zaharoff DA: Localized Interleukin-12 for cancer immunotherapy. Front Immunol. 11(575597)2020.PubMed/NCBI View Article : Google Scholar

37 

Achuthan AA, Lee KMC and Hamilton JA: Targeting GM-CSF in inflammatory and autoimmune disorders. Semin Immunol. 54(101523)2021.PubMed/NCBI View Article : Google Scholar

38 

Kursunel MA and Esendagli G: The untold story of IFN-γ in cancer biology. Cytokine Growth Factor Rev. 31:73–81. 2016.PubMed/NCBI View Article : Google Scholar

39 

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y and Li Y: Inflammation and tumor progression: Signaling pathways and targeted intervention. Signal Transduct Target Ther. 6(263)2021.PubMed/NCBI View Article : Google Scholar

40 

Micev M and Cosić-Micev M: Pathology and pathobiology of the gastric carcinoma. Acta Chir Iugosl. 58:39–52. 2011.PubMed/NCBI View Article : Google Scholar : (In Serbian).

41 

Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG and Wang TC: Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell. 14:408–419. 2008.PubMed/NCBI View Article : Google Scholar

42 

Cheng D, Hao Y, Zhou W and Ma Y: Positive association between Interleukin-8-251A>T polymorphism and susceptibility to gastric carcinogenesis: A meta-analysis. Cancer Cell Int. 13(100)2013.PubMed/NCBI View Article : Google Scholar

43 

Sun PS, Gao ZJ, Fan LX, Liu YF, Chen BH, Mu SZ and Yan ZQ: The regulatory function of tumor-infiltrating Th9 cells to anti-tumor activity of CD8(+) T cells in patients with gastric cancer. Zhonghua Zhong Liu Za Zhi. 44:1186–1193. 2022.PubMed/NCBI View Article : Google Scholar : (In Chinese).

44 

Jakobisiak M, Golab J and Lasek W: Interleukin 15 as a promising candidate for tumor immunotherapy. Cytokine Growth Factor Rev. 22:99–108. 2011.PubMed/NCBI View Article : Google Scholar

45 

Shi JL, Zheng ZM, Chen M, Shen HH, Li MQ and Shao J: IL-17: An important pathogenic factor in endometriosis. Int J Med Sci. 19:769–778. 2022.PubMed/NCBI View Article : Google Scholar

46 

Meng XY, Zhou CH, Ma J, Jiang C and Ji P: Expression of interleukin-17 and its clinical significance in gastric cancer patients. Med Oncol. 29:3024–3028. 2012.PubMed/NCBI View Article : Google Scholar

47 

Florkiewicz RZ, Ahluwalia A, Sandor Z, Szabo S and Tarnawski AS: Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Biochem Biophys Res Commun. 409:494–499. 2011.PubMed/NCBI View Article : Google Scholar

48 

Xue Y, Lim S, Yang Y, Wang Z, Jensen LD, Hedlund EM, Andersson P, Sasahara M, Larsson O, Galter D, et al: PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat Med. 18:100–110. 2011.PubMed/NCBI View Article : Google Scholar

49 

Shi L, Wang L and Wang X: Osteopontin induces Epithelial-to-Mesenchymal transitions in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways. Chest. 149(A332)2016.

50 

Ruhwald M, Aabye MG and Ravn P: IP-10 release assays in the diagnosis of tuberculosis infection: Current status and future directions. Expert Rev Mol Diagn. 12:175–187. 2012.PubMed/NCBI View Article : Google Scholar

51 

Singh S, Anshita D and Ravichandiran V: MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 101(107598)2021.PubMed/NCBI View Article : Google Scholar

52 

Yoshimura T: The chemokine MCP-1 (CCL2) in the host interaction with cancer: A foe or ally? Cell Mol Immunol. 15:335–345. 2018.PubMed/NCBI View Article : Google Scholar

53 

Hata H: Bone lesions and macrophage inflammatory protein-1 alpha (MIP-1a) in human multiple myeloma. Leuk Lymphoma. 46:967–972. 2005.PubMed/NCBI View Article : Google Scholar

54 

Schröder JM: Peptides and cytokines. Arch Dermatol Res. 284 (Suppl 1):S22–S26. 1992.PubMed/NCBI View Article : Google Scholar

55 

Shim YJ, Kang BH, Choi BK, Park IS and Min BH: Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages. Biochem Biophys Res Commun. 422:200–205. 2012.PubMed/NCBI View Article : Google Scholar

56 

Propst SM, Estell K and Schwiebert LM: CD40-mediated activation of NF-kappa B in airway epithelial cells. J Biol Chem. 277:37054–37063. 2002.PubMed/NCBI View Article : Google Scholar

57 

Wang Y, Bao M, Hou C, Wang Y, Zheng L and Peng Y: The Role of TNF-α in the pathogenesis of Temporomandibular disorders. Biol Pharm Bull. 44:1801–1809. 2021.PubMed/NCBI View Article : Google Scholar

58 

Peng K, Bai Y, Zhu Q, Hu B and Xu Y: Targeting VEGF-neuropilin interactions: A promising antitumor strategy. Drug Discov Today. 24:656–664. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Peng J and Su X: Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin. Mol Clin Oncol 20: 9, 2024.
APA
Li, X., Peng, J., & Su, X. (2024). Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin. Molecular and Clinical Oncology, 20, 9. https://doi.org/10.3892/mco.2023.2707
MLA
Li, X., Peng, J., Su, X."Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin". Molecular and Clinical Oncology 20.1 (2024): 9.
Chicago
Li, X., Peng, J., Su, X."Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin". Molecular and Clinical Oncology 20, no. 1 (2024): 9. https://doi.org/10.3892/mco.2023.2707
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Peng J and Su X: Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin. Mol Clin Oncol 20: 9, 2024.
APA
Li, X., Peng, J., & Su, X. (2024). Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin. Molecular and Clinical Oncology, 20, 9. https://doi.org/10.3892/mco.2023.2707
MLA
Li, X., Peng, J., Su, X."Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin". Molecular and Clinical Oncology 20.1 (2024): 9.
Chicago
Li, X., Peng, J., Su, X."Expression of immune regulatory factors, chemokines and growth factors in differentiated gastric cancer cells treated with an anticancer bioactive peptide combined with oxaliplatin". Molecular and Clinical Oncology 20, no. 1 (2024): 9. https://doi.org/10.3892/mco.2023.2707
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