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lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis

  • Authors:
    • Peng Yu
    • Jiemei Ye
    • Shujian Zhao
    • Yonglin Cai
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541199, P.R. China, Guangxi Health Commission Key Laboratory of Molecular Epidemiology of Nasopharyngeal Carcinoma, Wuzhou Red Cross Hospital, Wuzhou, Guangxi Zhuang Autonomous Region 543002, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 11
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    Published online on: December 14, 2023
       https://doi.org/10.3892/mco.2023.2709
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Abstract

The present study aimed to investigate the association between the expression profiles of long non‑coding RNAs (lncRNAs) and the clinical characteristics or prognosis of patients with nasopharyngeal carcinoma (NPC). The findings presented in the present review may provide novel strategies for the prevention and treatment of NPC. For the analyses, medical databases, including PubMed, Web of Science and Cochrane library were searched using specific search terms, search strategies and screening strategies. Endnote X9 document management software was then employed to extract documents from January, 2010 to May, 2023. Data were extracted following the prescribed standards. Review Manager 5.4 and STATA 12.0 data analysis software were used for data analysis. A total of 490 publications were analyzed for inclusion. In total, 29 publications, composed of 24 studies with upregulated lncRNAs and 5 studies with downregulated lncRNAs, were included in the final analysis. The analysis revealed that the upregulation of lncRNAs was significantly associated with T stage, N stage and clinical stage, as well as with the overall survival (OS) and disease‑free survival (DFS) of patients with NPC (P<0.05). However, there was no significant association between the upregulated lncRNAs and sex, M stage or relapse‑free survival (RFS) (P>0.05). On the other hand, the suppression of lncRNA expression was significantly associated with N stage, M stage, clinical stage and the OS of patients with NPC (P<0.05), but not with T stage and RFS (P>0.05). Taken together, the present review demonstrates that the up‑ and downregulation of different lncRNAs was associated with an advanced clinical stage and a shorter OS of patients with NPC. Therefore, lncRNAs may serve as potential prognostic factors in NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu P, Ye J, Zhao S and Cai Y: lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis. Mol Clin Oncol 20: 11, 2024.
APA
Yu, P., Ye, J., Zhao, S., & Cai, Y. (2024). lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 20, 11. https://doi.org/10.3892/mco.2023.2709
MLA
Yu, P., Ye, J., Zhao, S., Cai, Y."lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis". Molecular and Clinical Oncology 20.2 (2024): 11.
Chicago
Yu, P., Ye, J., Zhao, S., Cai, Y."lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis". Molecular and Clinical Oncology 20, no. 2 (2024): 11. https://doi.org/10.3892/mco.2023.2709
Copy and paste a formatted citation
x
Spandidos Publications style
Yu P, Ye J, Zhao S and Cai Y: lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis. Mol Clin Oncol 20: 11, 2024.
APA
Yu, P., Ye, J., Zhao, S., & Cai, Y. (2024). lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 20, 11. https://doi.org/10.3892/mco.2023.2709
MLA
Yu, P., Ye, J., Zhao, S., Cai, Y."lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis". Molecular and Clinical Oncology 20.2 (2024): 11.
Chicago
Yu, P., Ye, J., Zhao, S., Cai, Y."lncRNAs are potential prognostic markers in patients with nasopharyngeal carcinoma in China: A systematic review and meta‑analysis". Molecular and Clinical Oncology 20, no. 2 (2024): 11. https://doi.org/10.3892/mco.2023.2709
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