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Article

Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio

  • Authors:
    • Hiroko Shimada
    • Akihiro Fujimoto
    • Kazuo Matsuura
    • Shunsuke Kohyama
    • Asami Nukui
    • Yuki Ichinose
    • Aya Asano
    • Masahiro Ohara
    • Hiroshi Ishiguro
    • Akihiko Osaki
    • Toshiaki Saeki
  • View Affiliations / Copyright

    Affiliations: Department of Breast Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama 350‑1298, Japan, Department of Pharmacy, Saitama Medical University International Medical Center, Hidaka, Saitama 350‑1298, Japan, Department of Breast Oncology, Saitama Medical University Hospital, Moroyama‑machi, Saitama 350‑0495, Japan
  • Article Number: 15
    |
    Published online on: January 3, 2024
       https://doi.org/10.3892/mco.2024.2713
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Abstract

Eribulin is widely used to treat metastatic breast cancer (BC). Higher neutrophil‑to‑lymphocyte ratio (NLR) and platelet‑to‑lymphocyte ratio (PLR) are associated with higher mortality in several cancer types. However, the association between BC prognosis and peripheral immune status remains controversial. In the present study, the relative effects of NLR and PLR on survival in patients with metastatic BC were quantified and their clinical prognostic value was evaluated. This retrospective study included 156 patients with metastatic BC who received eribulin monotherapy at Saitama Medical University International Medical Center. Clinicopathological features were examined (peripheral blood findings and biochemical liver and kidney function test results) and univariate and multivariate analyses were conducted of the overall survival (OS). The 156 patients treated with eribulin had a median follow‑up duration of 18.3 months. Before eribulin treatment, patients with absolute lymphocyte counts (ALC) >1,500/µl, NLR <3.0, and PLR <150 had significantly longer OS than those with lower ALC, and higher NLR and PLR (median OS, 25.5 vs. 15.5 months; P<0.01; 20.3 vs. 13.6 months, P<0.01; and 29.2 vs. 14.8 months; P<0.001, respectively). Patients with anemia [hemoglobin (Hb) <10 g/dl] or liver dysfunction [albumin‑bilirubin (ALBI) grade 2/3] had significantly shorter OS than those without (P<0.001, respectively). Multivariate analysis revealed low ALBI grade (P<0.001), high Hb (P<0.01) and low PLR (P<0.05) as independent factors of longer OS after eribulin administration. Low PLR, anemia and liver dysfunction might be factors associated with prolonged OS in patients with metastatic BC on eribulin therapy, which could be clinically useful, as their evaluation requires neither new equipment nor invasive testing.
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Copy and paste a formatted citation
Spandidos Publications style
Shimada H, Fujimoto A, Matsuura K, Kohyama S, Nukui A, Ichinose Y, Asano A, Ohara M, Ishiguro H, Osaki A, Osaki A, et al: Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio. Mol Clin Oncol 20: 15, 2024.
APA
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y. ... Saeki, T. (2024). Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio. Molecular and Clinical Oncology, 20, 15. https://doi.org/10.3892/mco.2024.2713
MLA
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y., Asano, A., Ohara, M., Ishiguro, H., Osaki, A., Saeki, T."Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio". Molecular and Clinical Oncology 20.2 (2024): 15.
Chicago
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y., Asano, A., Ohara, M., Ishiguro, H., Osaki, A., Saeki, T."Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio". Molecular and Clinical Oncology 20, no. 2 (2024): 15. https://doi.org/10.3892/mco.2024.2713
Copy and paste a formatted citation
x
Spandidos Publications style
Shimada H, Fujimoto A, Matsuura K, Kohyama S, Nukui A, Ichinose Y, Asano A, Ohara M, Ishiguro H, Osaki A, Osaki A, et al: Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio. Mol Clin Oncol 20: 15, 2024.
APA
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y. ... Saeki, T. (2024). Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio. Molecular and Clinical Oncology, 20, 15. https://doi.org/10.3892/mco.2024.2713
MLA
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y., Asano, A., Ohara, M., Ishiguro, H., Osaki, A., Saeki, T."Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio". Molecular and Clinical Oncology 20.2 (2024): 15.
Chicago
Shimada, H., Fujimoto, A., Matsuura, K., Kohyama, S., Nukui, A., Ichinose, Y., Asano, A., Ohara, M., Ishiguro, H., Osaki, A., Saeki, T."Comprehensive prognostic prediction of metastatic breast cancer treated with eribulin using blood‑based parameters and ratio". Molecular and Clinical Oncology 20, no. 2 (2024): 15. https://doi.org/10.3892/mco.2024.2713
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