Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2024 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2024 Volume 20 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review

  • Authors:
    • Meiqing Wu
    • Zhongqing Li
    • Lin Luo
    • Weihua Zhao
    • Jun Luo
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 16
    |
    Published online on: January 4, 2024
       https://doi.org/10.3892/mco.2024.2714
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angiosarcomas, originating from endothelial cells, are infrequent soft tissue sarcomas characterized by a high propensity for metastasis and an unfavorable prognosis. Splenic angiosarcoma, an exceedingly rare and aggressive neoplasm, exhibits variable clinical manifestations. The present case report describes a patient initially exhibiting anemia and bone marrow fibrosis, mimicking primary myelofibrosis, ultimately diagnosed with splenic angiosarcoma. The findings of the present case report underscore the importance of considering splenectomy for histopathological confirmation. Employing a panel of vascular differentiation markers is invaluable for establishing the diagnosis of angiosarcoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Young RJ, Brown NJ, Reed MW, Hughes D and Woll PJ: Angiosarcoma. Lancet Oncol. 11:983–991. 2010.PubMed/NCBI View Article : Google Scholar

2 

Wheelwright M, Spartz EJ, Skubitz K, Yousaf H, Murugan P and Harmon JV: Primary angiosarcoma of the spleen, a rare indication for splenectomy: A case report. Int J Surg Case Rep. 82(105929)2021.PubMed/NCBI View Article : Google Scholar

3 

Guglielmelli P, Rotunno G, Pacilli A, Rumi E, Rosti V, Delaini F, Maffioli M, Fanelli T, Pancrazzi A, Pieri L, et al: Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients. Am J Hematol. 91:918–922. 2016.PubMed/NCBI View Article : Google Scholar

4 

Neuhauser TS, Derringer GA, Thompson LD, Fanburg-Smith JC, Miettinen M, Saaristo A and Abbondanzo SL: Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases. Mod Pathol. 13:978–987. 2000.PubMed/NCBI View Article : Google Scholar

5 

Kania BE and Vasani S: A case report of splenic rupture secondary to underlying angiosarcoma. Cureus. 12(e9439)2020.PubMed/NCBI View Article : Google Scholar

6 

Fury MG, Antonescu CR, Van Zee KJ, Brennan MF and Maki RG: A 14-year retrospective review of angiosarcoma: Clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 11:241–247. 2005.PubMed/NCBI View Article : Google Scholar

7 

Gorzelak-Pabis P, Zuszek-Frynas A and Broncel M: Primary splenic angiosarcoma: A very rare and aggressive neoplasm with a poor prognosis. Pol Arch Intern Med. 130:142–144. 2020.PubMed/NCBI View Article : Google Scholar

8 

Damouny M, Mansour S and Khuri S: Primary Angiosarcoma of the Spleen: An aggressive neoplasm. World J Oncol. 13:337–342. 2022.PubMed/NCBI View Article : Google Scholar

9 

Xu B, Xie X, Zhou X, Zhai M and Yang W: Spontaneous rupture of primary splenic angiosarcoma: A case report. Oncol Lett. 10:3271–3273. 2015.PubMed/NCBI View Article : Google Scholar

10 

Khorzhevskii VA, Ermachenko DA, Gappoev SV and Levkovich LG: Metastatic lesion of the bone marrow caused by primary angiosarcoma of the spleen. Arkh Patol. 84:52–55. 2022.PubMed/NCBI View Article : Google Scholar : (In Russian).

11 

Badiani R, Schaller G, Jain K, Swamy R and Gupta S: Angiosarcoma of the spleen presenting as spontaneous splenic rupture: A rare case report and review of the literature. Int J Surg Case Rep. 4:765–767. 2013.PubMed/NCBI View Article : Google Scholar

12 

Koutelidakis IM, Tsiaousis PZ, Papaziogas BT, Patsas AG, Atmatzidis SK and Atmatzidis KS: Spleen rupture due to primary angiosarcoma: A case report. J Gastrointest Cancer. 38:74–77. 2007.PubMed/NCBI View Article : Google Scholar

13 

Ozcan B, Cevener M, Kargi AO, Dikici H, Yıldız A, Özdoğan M and Gürkan A: Primary splenic angiosarcoma diagnosed after splenectomy for spontaneous rupture. Turk J Surg. 34:68–70. 2018.PubMed/NCBI View Article : Google Scholar

14 

Levy ACJ, DeFilipp M, Blakely M, Asiry S, Jormark S and Goodman A: Splenic angiosarcoma diagnosed on bone marrow biopsy: Case report and literature review. Radiol Case Rep. 14:390–395. 2019.PubMed/NCBI View Article : Google Scholar

15 

Li R, Li M, Zhang LF, Liu XM, Hu TZ, Xia XJ, Chi JS, Jiang XX and Xu CX: Clinical characteristics and prognostic factors of primary splenic angiosarcoma: A retrospective clinical analysis from China. Cell Physiol Biochem. 49:1959–1969. 2018.PubMed/NCBI View Article : Google Scholar

16 

Takahashi H, Hara T, Suzuki H, Hashimoto R and Minami M: FDG-PET/CT demonstrates splenic angiosarcoma bone marrow metastasis. Clin Nucl Med. 45:e20–e23. 2020.PubMed/NCBI View Article : Google Scholar

17 

Abdallah RA, Abdou AG, Asaad NY, Al-Sharaky DR and Alhanafy AM: Primary epithelioid angiosarcoma of spleen: A case report and review of literature. J Clin Diagn Res. 10:ED05–ED07. 2016.PubMed/NCBI View Article : Google Scholar

18 

Chen D, Tang M, Lv S, Wang H, Du W, Zhao X, Lin L, Zhu Y, Wang G, Zhu H and Zhao K: Prognostic usefulness of clinical features and pretreatment (18)F-FDG PET/CT metabolic parameters in patients with angiosarcoma. Quant Imaging Med Surg. 12:2792–2804. 2022.PubMed/NCBI View Article : Google Scholar

19 

An R, Ma JY, Ni XH and Wang CL: Angiosarcoma of the breast with hypofibrinogenemia: A rare case report and review of the literature. Front Oncol. 12(1047935)2022.PubMed/NCBI View Article : Google Scholar

20 

Mori S, Taki T, Murakami Y, Urata T, Okumura M, Akanabe H, Ebata A, Imai S, Yokota K and Akiyama M: Low plasma fibrinogen levels are associated with poor prognosis in cutaneous angiosarcoma of the head and neck. Cancer Sci. 112:3924–3927. 2021.PubMed/NCBI View Article : Google Scholar

21 

Juin Hsien BL and Shelat VG: Spleen angiosarcoma: A world review. Expert Rev Gastroenterol Hepatol. 15:1115–1141. 2021.PubMed/NCBI View Article : Google Scholar

22 

Smrke A, Hamm J, Karvat A, Simmons C and Srikanthan A: A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival. Mol Clin Oncol. 13:179–185. 2020.PubMed/NCBI View Article : Google Scholar

23 

Zhao Q, Dong A, Wang Y, He T and Zuo C: FDG PET/CT in primary splenic angiosarcoma with diffuse involvement of the spleen. Clin Nucl Med. 42:815–817. 2017.PubMed/NCBI View Article : Google Scholar

24 

Yamamoto T, Umeda T and Nishioka K: Immunohistological distribution of stem cell factor and kit receptor in angiosarcoma. Acta Derm Venereol. 80:443–445. 2000.PubMed/NCBI View Article : Google Scholar

25 

Shantzer L, Berger K and Pu JJ: Primary myelofibrosis and its targeted therapy. Ann Hematol. 96:531–535. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu M, Li Z, Luo L, Zhao W and Luo J: Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review. Mol Clin Oncol 20: 16, 2024.
APA
Wu, M., Li, Z., Luo, L., Zhao, W., & Luo, J. (2024). Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review. Molecular and Clinical Oncology, 20, 16. https://doi.org/10.3892/mco.2024.2714
MLA
Wu, M., Li, Z., Luo, L., Zhao, W., Luo, J."Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review". Molecular and Clinical Oncology 20.2 (2024): 16.
Chicago
Wu, M., Li, Z., Luo, L., Zhao, W., Luo, J."Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review". Molecular and Clinical Oncology 20, no. 2 (2024): 16. https://doi.org/10.3892/mco.2024.2714
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Li Z, Luo L, Zhao W and Luo J: Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review. Mol Clin Oncol 20: 16, 2024.
APA
Wu, M., Li, Z., Luo, L., Zhao, W., & Luo, J. (2024). Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review. Molecular and Clinical Oncology, 20, 16. https://doi.org/10.3892/mco.2024.2714
MLA
Wu, M., Li, Z., Luo, L., Zhao, W., Luo, J."Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review". Molecular and Clinical Oncology 20.2 (2024): 16.
Chicago
Wu, M., Li, Z., Luo, L., Zhao, W., Luo, J."Metastatic splenic angiosarcoma presenting with anemia and bone marrow fibrosis mimicking primary myelofibrosis: A case report and literature review". Molecular and Clinical Oncology 20, no. 2 (2024): 16. https://doi.org/10.3892/mco.2024.2714
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team