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Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma

  • Authors:
    • Kenji Makita
    • Yasushi Hamamoto
    • Hiromitsu Kanzaki
    • Ayu Makita
    • Kei Nagasaki
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791-0280, Japan, Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan
    Copyright: © Makita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 19
    |
    Published online on: January 16, 2024
       https://doi.org/10.3892/mco.2024.2717
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Abstract

The present study investigated the factors contributing to cardiac volume reduction (CVR) during radiotherapy (RT) in patients with esophageal carcinoma (EC). This retrospective study included patients with EC treated at National Hospital Organization Shikoku Cancer Center (Matsuyama, Japan). Cardiac delineation was based on initial and off‑cord boost (spinal cord‑sparing approach) planning computed tomography images. The relationship between CVR and other relevant parameters was analyzed. A total of 58 patients with EC were investigated between January 2016 and January 2022. Univariate and multiple regression analyses revealed a statistically significant association between CVR during RT and the change ratio of the inferior vena cava (IVC) volume and body mass index (BMI) loss. In multivariate analysis of CVR of >10%, only the change in IVC volume exhibited a significant association. Conversely, CVR during RT displayed no association with heart dose‑volume parameters, laboratory data, or changes in blood pressure and pulse rate. Among the 12 cases with CVR of >10%, the median movement of the left anterior descending coronary artery region (LADR) was 1.35 cm (range, 0.0‑2.7 cm). In conclusion, CVR during RT was most strongly associated with changes in IVC volume, suggesting dehydration as the primary cause, rather than radiation‑induced heart damage. LADR movement due to a CVR of >10% may lead to LADR radiation overdose.
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Copy and paste a formatted citation
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Makita A and Nagasaki K: Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma. Mol Clin Oncol 20: 19, 2024.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., & Nagasaki, K. (2024). Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma. Molecular and Clinical Oncology, 20, 19. https://doi.org/10.3892/mco.2024.2717
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., Nagasaki, K."Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma". Molecular and Clinical Oncology 20.3 (2024): 19.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., Nagasaki, K."Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma". Molecular and Clinical Oncology 20, no. 3 (2024): 19. https://doi.org/10.3892/mco.2024.2717
Copy and paste a formatted citation
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Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Makita A and Nagasaki K: Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma. Mol Clin Oncol 20: 19, 2024.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., & Nagasaki, K. (2024). Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma. Molecular and Clinical Oncology, 20, 19. https://doi.org/10.3892/mco.2024.2717
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., Nagasaki, K."Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma". Molecular and Clinical Oncology 20.3 (2024): 19.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Makita, A., Nagasaki, K."Cardiac volume reduction during radiotherapy in patients with esophageal carcinoma". Molecular and Clinical Oncology 20, no. 3 (2024): 19. https://doi.org/10.3892/mco.2024.2717
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