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Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization

  • Authors:
    • Mi Fan
    • Tingting Niu
    • Binwei Lin
    • Feng Gao
    • Bangxian Tan
    • Xiaobo Du
  • View Affiliations / Copyright

    Affiliations: Departmant of Oncology, NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang, Sichuan 621000, P.R. China, Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nan Chong, Sichuan 637000, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 22
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    Published online on: January 24, 2024
       https://doi.org/10.3892/mco.2024.2720
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Abstract

The present study investigated the prognostic impact of preoperative serum ferritin (SF) levels on the survival of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). Clinicopathological characteristics and laboratory biomarkers of 223 patients with HCC who underwent TACE were retrospectively reviewed. The Kaplan‑Meier method was used to calculate the overall survival (OS), and the log‑rank test was used to evaluate statistical significance. Univariate and multivariate analyses were performed using Cox proportional hazards regression to evaluate the prognostic impact of SF in these patients. The present findings identified extrahepatic metastases [hazard ratio (HR)=0.490,95%; confidence interval (CI)=0.282‑0.843; P=0.010)] and vascular invasion (HR=0.373; 95% CI=0.225‑0.619; P<0.0001) as independent prognostic factors for OS. However, preoperative SF levels could not independently predict OS when compared with other prognostic factors (HR=0.810; 95% CI=0.539‑1.216; P=0.309). In conclusion, preoperative SF level is an unreliable biochemical predictor of survival in patients with HCC undergoing TACE.
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Copy and paste a formatted citation
Spandidos Publications style
Fan M, Niu T, Lin B, Gao F, Tan B and Du X: Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization. Mol Clin Oncol 20: 22, 2024.
APA
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., & Du, X. (2024). Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization. Molecular and Clinical Oncology, 20, 22. https://doi.org/10.3892/mco.2024.2720
MLA
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., Du, X."Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization". Molecular and Clinical Oncology 20.3 (2024): 22.
Chicago
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., Du, X."Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization". Molecular and Clinical Oncology 20, no. 3 (2024): 22. https://doi.org/10.3892/mco.2024.2720
Copy and paste a formatted citation
x
Spandidos Publications style
Fan M, Niu T, Lin B, Gao F, Tan B and Du X: Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization. Mol Clin Oncol 20: 22, 2024.
APA
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., & Du, X. (2024). Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization. Molecular and Clinical Oncology, 20, 22. https://doi.org/10.3892/mco.2024.2720
MLA
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., Du, X."Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization". Molecular and Clinical Oncology 20.3 (2024): 22.
Chicago
Fan, M., Niu, T., Lin, B., Gao, F., Tan, B., Du, X."Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization". Molecular and Clinical Oncology 20, no. 3 (2024): 22. https://doi.org/10.3892/mco.2024.2720
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