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Article Open Access

TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma

  • Authors:
    • Teng Long
    • Weijie Wu
    • Xin Wang
    • Minshan Chen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in South China, Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Long et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
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    Published online on: February 8, 2024
       https://doi.org/10.3892/mco.2024.2725
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Abstract

Liver cancer is the fourth leading cause of cancer‑related mortality worldwide and hepatocellular carcinoma (HCC) is the most common primary liver cancer. In the present study, it was demonstrated that translocated promoter region (TPR) was upregulated in tumor tissues and associated with prognosis and immune infiltration in HCC. The clinical outcome of patients with HCC with aberrant expression of TPR was examined using multiple databases, including Gene Expression Omnibus, The Cancer Genome Atlas (TCGA), Genotype‑Tissue Expression, Kaplan‑Meier (KM) Plotter and Xiantao tool. The clinicopathologic characteristics of patients from TCGA database that were associated with overall survival were assessed using Cox regression and KM analysis. The potential hallmarks associated with TPR expression were further predicted by Metascape and Gene Set Enrichment Analysis, and the relationship between TPR and immune infiltration was explored using the Tumor‑Immune System Interactions Database and the Tumor Immune Estimation Resource. The results demonstrated that TPR expression was higher in HCC and its overexpression was associated with a worse prognosis, alongside a correlation with several clinical features. Furthermore, cell differentiation, a prospective new hallmark of cancer, was differentially enriched in the high TPR expression phenotype pathway. Moreover, TPR may also modulate the tumor immune microenvironment as it was significantly associated with immunoregulators and chemokines, as well as different tumor infiltration immune cells. According to the in vitro experiments, TPR silencing inhibited the phosphorylation of AKT and the proliferation of HCC cells. In summary, TPR may be a new marker and target for HCC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Long T, Wu W, Wang X and Chen M: TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma. Mol Clin Oncol 20: 27, 2024.
APA
Long, T., Wu, W., Wang, X., & Chen, M. (2024). TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma. Molecular and Clinical Oncology, 20, 27. https://doi.org/10.3892/mco.2024.2725
MLA
Long, T., Wu, W., Wang, X., Chen, M."TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma". Molecular and Clinical Oncology 20.4 (2024): 27.
Chicago
Long, T., Wu, W., Wang, X., Chen, M."TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma". Molecular and Clinical Oncology 20, no. 4 (2024): 27. https://doi.org/10.3892/mco.2024.2725
Copy and paste a formatted citation
x
Spandidos Publications style
Long T, Wu W, Wang X and Chen M: TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma. Mol Clin Oncol 20: 27, 2024.
APA
Long, T., Wu, W., Wang, X., & Chen, M. (2024). TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma. Molecular and Clinical Oncology, 20, 27. https://doi.org/10.3892/mco.2024.2725
MLA
Long, T., Wu, W., Wang, X., Chen, M."TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma". Molecular and Clinical Oncology 20.4 (2024): 27.
Chicago
Long, T., Wu, W., Wang, X., Chen, M."TPR is a prognostic biomarker and potential therapeutic target associated with immune infiltration in hepatocellular carcinoma". Molecular and Clinical Oncology 20, no. 4 (2024): 27. https://doi.org/10.3892/mco.2024.2725
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